INT41495

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Context Info
Confidence 0.42
First Reported 1980
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.96
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Sp1) nucleus (Sp1) intracellular (Sp1)
DNA binding (Sp1) transcription factor binding (Sp1) cytoplasm (Sp1)
Anatomy Link Frequency
muscle 1
Sp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 6 100.00 Very High Very High Very High
antidepressant 4 100.00 Very High Very High Very High
qutenza 4 99.08 Very High Very High Very High
Hippocampus 4 98.16 Very High Very High Very High
fluoxetine 4 93.52 High High
tetrodotoxin 3 92.76 High High
Inflammation 75 92.32 High High
Desipramine 6 92.32 High High
Potency 1 80.00 Quite High
methotrexate 50 78.56 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 13 97.52 Very High Very High Very High
Renal Disease 6 94.84 High High
Apoptosis 6 92.76 High High
INFLAMMATION 79 92.32 High High
Injury 7 90.96 High High
Repression 2 86.60 High High
Renal Failure 4 84.04 Quite High
Pressure Volume 2 Under Development 8 81.88 Quite High
Albuminuria 12 79.60 Quite High
Coronary Heart Disease 12 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of chronic antidepressant administration on CRE-, SP1- and GRE-binding activity was studied in rat hippocampus and frontal cortex. 2.
Regulation (effect) of SP1 associated with antidepressant, urological neuroanatomy and hippocampus
1) Confidence 0.42 Published 1998 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 9723120 Disease Relevance 0.29 Pain Relevance 0.49
Capsaicin pretreatment of newborn or adult rats had no effect on intestinal I-SP concentrations indicating that intrinsic SP neurones are capsaicin-insensitive.
Neg (no) Regulation (effect) of I-SP associated with qutenza and substance p
2) Confidence 0.22 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6153986 Disease Relevance 0 Pain Relevance 0.54
The expression of IL-10 is under the control of the Sp1 transcription factor that is also regulated by MAPK pathway [51].
Regulation (regulated) of Sp1 transcription factor
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.61 Pain Relevance 0.15
This inhibition is selective, as the activity of four other transcription factors, Oct-1, TBP, Sp1 and STAT 5 was not affected.
Neg (not) Regulation (affected) of Sp1
4) Confidence 0.07 Published 1997 Journal Biol. Chem. Section Abstract Doc Link 9348104 Disease Relevance 0.36 Pain Relevance 0.37
Electrical activity regulates AChR gene expression via JNK, PKCzeta and Sp1 in skeletal chick muscle.
Regulation (regulates) of Sp1 in muscle
5) Confidence 0.07 Published 2001 Journal FEBS Lett. Section Title Doc Link 11163354 Disease Relevance 0.09 Pain Relevance 0.26
B, but had no effect on AP-1, CREB, Sp-1, and octamer-binding proteins [14,15].
Neg (no) Regulation (effect) of Sp-1
6) Confidence 0.04 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.62 Pain Relevance 0.10
B activation of various stimulants, but had no effect on AP-1, CREB, Sp-1, and octamer-binding proteins in several cell lines and in vivo [14,15].
Neg (no) Regulation (effect) of Sp-1
7) Confidence 0.02 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.99 Pain Relevance 0.15

General Comments

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