INT41506

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Context Info
Confidence 0.64
First Reported 1981
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.51
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptgir) signal transducer activity (Ptgir)
Anatomy Link Frequency
plasma 1
blood 1
endothelial cells 1
heart 1
Ptgir (Rattus norvegicus)
Pain Link Frequency Relevance Heat
noradrenaline 2 99.82 Very High Very High Very High
qutenza 5 97.56 Very High Very High Very High
Angina 1 97.44 Very High Very High Very High
calcitonin gene related peptide 3 96.92 Very High Very High Very High
ischemia 3 95.88 Very High Very High Very High
aspirin 4 95.36 Very High Very High Very High
Pain 6 88.64 High High
cINOD 2 51.68 Quite High
fibrosis 3 49.56 Quite Low
cva 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 4 100.00 Very High Very High Very High
Cv General 3 Under Development 3 97.44 Very High Very High Very High
Coronary Artery Disease 8 96.32 Very High Very High Very High
Arteriosclerosis Obliterans 2 95.28 Very High Very High Very High
Natriuresis 2 93.24 High High
Muscular Spasm 1 91.52 High High
Pulmonary Hypertension 82 89.68 High High
Primary Pulmonary Hypertension 17 89.00 High High
Pain 6 88.64 High High
Atherosclerosis 1 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prostacyclin (PGI2) release was measured by the concentration of its stable metabolite, 6-keto-prostaglandin F1 alpha in plasma.
Localization (release) of Prostacyclin in plasma
1) Confidence 0.64 Published 1981 Journal Prostaglandins Section Abstract Doc Link 7041195 Disease Relevance 0.41 Pain Relevance 0.16
Other observations suggest that catechol estrogen can inhibit prostaglandin (PGI2) release in the endothelium, and we had found that androgen can relieve angina pectoris and improve myocardial ischemia in elderly men with coronary heart disease (CHD), possibly through relieving coronary artery smooth muscle spasm.
Localization (release) of PGI2 in heart associated with angina, coronary artery disease, ischemia and muscular spasm
2) Confidence 0.40 Published 1993 Journal Chin. Med. Sci. J. Section Abstract Doc Link 8032065 Disease Relevance 0.83 Pain Relevance 0.15
Release of the PGI2-like substance by angiotensin II was reduced after intravenous administration of indomethacin (2, 5, or 10 mg/kg), aspirin (100 mg/kg), aspirin (100 mg/kg), and meclofenamic acid (2 mg/kg), but was not completely eliminated by any of the above inhibitors.
Localization (Release) of PGI2 associated with aspirin
3) Confidence 0.04 Published 1981 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6160349 Disease Relevance 0.05 Pain Relevance 0.20
Neither arterial nor mixed venous blood contained measurable amounts of prostaglandin E2; infusions of noradrenaline did not release the PGI2-like substance.
Neg (not) Localization (release) of PGI2 in blood associated with noradrenaline
4) Confidence 0.03 Published 1981 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6160349 Disease Relevance 0 Pain Relevance 0.14
Prostacyclin (PGI2) – a metabolite of arachidonic acid – is endogenously produced by PGI2 synthase and released from pulmonary endothelial cells.
Localization (released) of Prostacyclin in endothelial cells
5) Confidence 0.02 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686263 Disease Relevance 1.02 Pain Relevance 0
Prostacyclin (PGI2) is also released during ischaemia.
Localization (released) of Prostacyclin associated with cv unclassified under development
6) Confidence 0.01 Published 1994 Journal Cardiovasc. Res. Section Abstract Doc Link 8174157 Disease Relevance 0.20 Pain Relevance 0.40

General Comments

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