INT4153

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Context Info
Confidence 0.40
First Reported 1976
Last Reported 2010
Negated 5
Speculated 4
Reported most in Abstract
Documents 109
Total Number 113
Disease Relevance 17.99
Pain Relevance 72.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Insrr)
Anatomy Link Frequency
brain 8
vas deferens 3
spinal cord 2
neurons 2
GPI 1
Insrr (Mus musculus)
Insrr - D95N (1)
Pain Link Frequency Relevance Heat
agonist 309 100.00 Very High Very High Very High
opioid receptor 214 100.00 Very High Very High Very High
Opioid 129 100.00 Very High Very High Very High
antagonist 120 100.00 Very High Very High Very High
nMDA receptor 83 100.00 Very High Very High Very High
opiate 55 100.00 Very High Very High Very High
Dopamine 55 100.00 Very High Very High Very High
antinociception 48 100.00 Very High Very High Very High
Cannabinoid 45 100.00 Very High Very High Very High
Cannabinoid receptor 41 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Tics 22 100.00 Very High Very High Very High
Natriuresis 7 100.00 Very High Very High Very High
Gliosis 1 99.88 Very High Very High Very High
Convulsion 152 99.80 Very High Very High Very High
Infection 6 99.48 Very High Very High Very High
Nociception 16 98.72 Very High Very High Very High
Morphine Dependence 27 98.44 Very High Very High Very High
Neuropathic Pain 63 97.92 Very High Very High Very High
Diabetes Mellitus 8 97.88 Very High Very High Very High
Hyperalgesia 60 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some of the more potent compounds such as 22, 26, 45, and 53 displayed alpha(2) receptor binding in the 10-20 nM range and also had significant antinociceptive activity in the mouse abdominal irritant test (MAIT).
receptor Binding (binding) of associated with antinociceptive
1) Confidence 0.40 Published 1999 Journal J. Med. Chem. Section Abstract Doc Link 10602691 Disease Relevance 0 Pain Relevance 0.30
Effect of morphinone on opiate receptor binding and morphine-elicited analgesia.
receptor Binding (binding) of associated with narcan, opiate, analgesia and morphine
2) Confidence 0.39 Published 1982 Journal Life Sci. Section Title Doc Link 6183553 Disease Relevance 0 Pain Relevance 1.16
The results show that m-xylene can induce eating and drinking response in mice, and it is suggested that there is a connection between this phenomenon and the decrease in alpha-receptor binding in the hypothalamus region.
receptor Binding (binding) of in hypothalamus
3) Confidence 0.39 Published 1985 Journal Neurobehav Toxicol Teratol Section Abstract Doc Link 3001550 Disease Relevance 0 Pain Relevance 0.08
In the short term, ethanol inhibited opiate receptor binding, but after long-term exposure the cells exhibited an apparent adaptive increase in the number of opiate binding sites; this was reversible when ethanol was withdrawn.
receptor Binding (binding) of associated with opiate
4) Confidence 0.35 Published 1983 Journal Science Section Abstract Doc Link 6316506 Disease Relevance 0.19 Pain Relevance 0.42
To this end, we compared cannabinoid receptor binding and WIN 55,212-2-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate ([35S]GTP gamma S) binding in several brain regions of mice chronically exposed to morphine or saline.
receptor Binding (binding) of in brain associated with cannabinoid receptor and morphine
5) Confidence 0.30 Published 1998 Journal Drug Alcohol Depend Section Abstract Doc Link 9649978 Disease Relevance 0.08 Pain Relevance 0.88
Thus, the data support the potential existence of a specific effect of morphine in the coupling of cannabinoid receptors to GTP-binding proteins, rather than on receptor binding, although this was observed only in the substantia nigra and central gray substance.
receptor Binding (binding) of in central gray associated with cannabinoid receptor, substantia nigra and morphine
6) Confidence 0.30 Published 1998 Journal Drug Alcohol Depend Section Abstract Doc Link 9649978 Disease Relevance 0 Pain Relevance 0.83
Autoradiographic analysis of cannabinoid receptor binding and cannabinoid agonist-stimulated [35S]GTP gamma S binding in morphine-dependent mice.
receptor Binding (binding) of associated with cannabinoid receptor, analgesic, cannabinoid, agonist and morphine
7) Confidence 0.30 Published 1998 Journal Drug Alcohol Depend Section Title Doc Link 9649978 Disease Relevance 0.08 Pain Relevance 1.29
In vitro receptor binding revealed an affinity decrease for delta in medulla and an increase in medulla and diencephalon for mu receptors after tolerance development to morphine.
receptor Binding (binding) of in medulla associated with medulla, tolerance and morphine
8) Confidence 0.30 Published 1984 Journal Neuropharmacology Section Abstract Doc Link 6325982 Disease Relevance 0 Pain Relevance 1.06
Several novel racemic aminotetralin derivatives have been prepared using a stereoselective aziridine ring opening reactions and were evaluated for their micro-opioid receptor binding affinity.
receptor Binding (affinity) of associated with opioid receptor
9) Confidence 0.30 Published 2002 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 12372519 Disease Relevance 0 Pain Relevance 0.22
Xylene induced feeding and drinking behavior and central adrenergic receptor binding.
receptor Binding (binding) of
10) Confidence 0.29 Published 1985 Journal Neurobehav Toxicol Teratol Section Title Doc Link 3001550 Disease Relevance 0 Pain Relevance 0.10
Mechanism of interaction of ET(A) receptor antagonists with morphine was investigated.
) receptor Binding (interaction) of associated with antagonist and morphine
11) Confidence 0.28 Published 2005 Journal Brain Res. Section Abstract Doc Link 16289404 Disease Relevance 0 Pain Relevance 1.60
Although the compounds had high affinity for both kappa and delta receptors in opioid receptor binding, they were very poor at antagonizing agonist responses mediated by kappa and particularly delta agonists in the mouse vas deferens preparation.
receptor Binding (binding) of in vas deferens associated with agonist and opioid receptor
12) Confidence 0.28 Published 1995 Journal J. Med. Chem. Section Abstract Doc Link 7636870 Disease Relevance 0 Pain Relevance 0.69
Therefore, ET(A) receptor antagonists did not bind directly to opioid receptors. [35S]GTPgammaS binding was stimulated by morphine and ET-1 in non-tolerant mice.
) receptor Neg (not) Binding (bind) of associated with antagonist, opioid receptor and morphine
13) Confidence 0.27 Published 2005 Journal Brain Res. Section Abstract Doc Link 16289404 Disease Relevance 0 Pain Relevance 1.90
Conventional opioids including opioid peptides require an "opioid" nitrogen which exists in protonated state while interacting with the receptor.
receptor Binding (interacting) of associated with opioid
14) Confidence 0.23 Published 1992 Journal Life Sci. Section Abstract Doc Link 1313941 Disease Relevance 0 Pain Relevance 0.58
A further significant decrease of melatonin receptor binding was induced by noxious stimulation.
receptor Binding (binding) of
15) Confidence 0.23 Published 2004 Journal Pain Section Abstract Doc Link 15275775 Disease Relevance 0.31 Pain Relevance 0.41
In vitro it has enkephalin-like character with a preference for the so called delta receptor interaction.
receptor Binding (interaction) of associated with enkephalin
16) Confidence 0.19 Published 1984 Journal J Auton Pharmacol Section Abstract Doc Link 6325463 Disease Relevance 0 Pain Relevance 0.75
CONCLUSIONS: These results are consistent with direct binding of volatile anesthetic agents to the GABA(A) receptor channel playing an important role in general anesthesia.
) receptor Binding (binding) of
17) Confidence 0.18 Published 1999 Journal Anesthesiology Section Body Doc Link 9952156 Disease Relevance 0 Pain Relevance 0
Genetic deletion of the adenosine A(2A) receptor in mice reduces the changes in spinal cord NMDA receptor binding and glucose uptake caused by a nociceptive stimulus.
receptor Binding (binding) of in spinal cord associated with nociception, pain, adenocard, nmda receptor and spinal cord
18) Confidence 0.15 Published 2010 Journal Neurosci. Lett. Section Title Doc Link 20570711 Disease Relevance 0.58 Pain Relevance 0.56
We tested this hypothesis by studying two parameters known to change with spinal cord activity, NMDA glutamate receptor binding and [(14)C]-2-deoxyglucose uptake, following intraplantar formalin injection in wild-type and A(2A) receptor knockout mice.
receptor Binding (binding) of in spinal cord associated with targeted disruption, glutamate receptor and spinal cord
19) Confidence 0.15 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20570711 Disease Relevance 0.66 Pain Relevance 0.44
Therefore, in the present report, receptor binding and pharmacological studies were performed to characterize the interaction between methamphetamine and sigma receptors.
receptor Binding (binding) of
20) Confidence 0.14 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15939443 Disease Relevance 0 Pain Relevance 0.10

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