INT41541

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Context Info
Confidence 0.41
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 3.82
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car1) Golgi apparatus (Car1) cytoplasm (Car1)
Anatomy Link Frequency
pyramidal neurons 8
hippocampus 4
neurons 2
brains 2
synapses 2
Car1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pyramidal cell 482 100.00 Very High Very High Very High
ASIC 108 100.00 Very High Very High Very High
ischemia 113 99.92 Very High Very High Very High
fluoxetine 1 99.52 Very High Very High Very High
Hippocampus 78 99.24 Very High Very High Very High
Desipramine 1 99.22 Very High Very High Very High
nMDA receptor 5 98.84 Very High Very High Very High
antidepressant 3 98.30 Very High Very High Very High
Glutamate 5 94.88 High High
tetrodotoxin 46 84.48 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 104 99.92 Very High Very High Very High
Post-traumatic Stress Disorder 27 99.20 Very High Very High Very High
Stress 54 98.48 Very High Very High Very High
Infection 56 96.92 Very High Very High Very High
Apoptosis 12 93.72 High High
Convulsion 11 93.44 High High
Death 23 82.60 Quite High
Cognitive Disorder 56 76.64 Quite High
Acidosis 20 72.32 Quite High
Stroke 6 66.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of ether and sodium pentobarbital on the synaptic transmission of the hippocampal CA1 region was studied in chronically implanted rats.
Regulation (effect) of Gene_expression (transmission) of CA1
1) Confidence 0.41 Published 1981 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 6163617 Disease Relevance 0 Pain Relevance 0
Therefore, to model the effects of endogenous choline on CA1 pyramidal ?
Regulation (effects) of Gene_expression (pyramidal) of CA1
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.10
A lack of substantial delay between pressure applications of choline and whole-cell responses of CA1 pyramidal neurons suggests that at least some pyramidal ?
Regulation (responses) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0.20 Pain Relevance 0.22
To model the effects of endogenous choline on CA1 pyramidal ?
Regulation (effects) of Gene_expression (pyramidal) of CA1
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0.07 Pain Relevance 0.22
These results demonstrated that a lack of responsiveness of CA1 pyramidal neurons to 0.5 mM choline does not necessarily reflect a lack of expression of functional ?
Regulation (responsiveness) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.25
Addition of 1 ┬ÁM PNU-120596 to ACSF significantly enhanced responses of hippocampal CA1 pyramidal neurons to pressure-applied 0.5 mM choline (p<0.017; n?
Regulation (responses) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.19
These results suggest a role of CA3 pyramidal neurons in the generation of CA1 theta via the activation of NMDA receptors of CA1 pyramidal neurons.
Regulation (role) of Gene_expression (generation) of CA1 in pyramidal neurons associated with nmda receptor and pyramidal cell
7) Confidence 0.26 Published 2002 Journal Hippocampus Section Abstract Doc Link 12201628 Disease Relevance 0 Pain Relevance 0.49
In sections from sham brains, TUNEL labeling was undetectable in the CA1 region (Figures 2a, 2e).
Regulation (undetectable) of Gene_expression (region) of CA1 in brains
8) Confidence 0.24 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.83 Pain Relevance 0.51
Our study showed that global ischemia up-regulated the expression of ASIC 2a in the hippocampal CA1 region.
Regulation (regulated) of Gene_expression (expression) of CA1 associated with ischemia and asic
9) Confidence 0.24 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.71 Pain Relevance 0.64
We found altered MR/GR ratio of both CA1-subregion and all hippocampus in the SPS animals.
Regulation (altered) of Gene_expression (ratio) of CA1 in hippocampus associated with stress and hippocampus
10) Confidence 0.23 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.87 Pain Relevance 0.45
days of injection, although a lot of neurons were labeled in CA1 region, only a few ?
Regulation (labeled) of Gene_expression (region) of CA1 in neurons
11) Confidence 0.23 Published 2008 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2629710 Disease Relevance 0.22 Pain Relevance 0.07
In view of the known connectivity, CA3 labeling with both vectors is most likely mediated through synapses of the CA3 Schaffer collaterals onto first order infected CA1 neurons.
Regulation (infected) of Gene_expression (neurons) of CA1 in synapses
12) Confidence 0.23 Published 2008 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2629710 Disease Relevance 0.08 Pain Relevance 0.09
Chronic (14 days) administration of different classes of antidepressant drugs, including tranylcypromine, desipramine, or fluoxetine, did not significantly affect the GDNF, GFRalpha-1, GFRalpha-2, or RET mRNA levels in CA1, CA3, and dentate gyrus areas of hippocampus.
Neg (not) Regulation (affect) of Gene_expression (levels) of CA1 in hippocampus associated with desipramine, antidepressant, hippocampus and fluoxetine
13) Confidence 0.22 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.82 Pain Relevance 0.30

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