INT41545

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Context Info
Confidence 0.57
First Reported 1981
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 2.99
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APRT) small molecule metabolic process (APRT) transferase activity, transferring glycosyl groups (APRT)
nucleolus (APRT) nucleus (APRT) cytoplasm (APRT)
Anatomy Link Frequency
neurons 1
skeletal muscle 1
T-cell 1
APRT (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 9 100.00 Very High Very High Very High
depression 5 100.00 Very High Very High Very High
rheumatoid arthritis 41 99.60 Very High Very High Very High
ischemia 1 99.56 Very High Very High Very High
Serotonin 9 99.48 Very High Very High Very High
tetrodotoxin 4 97.40 Very High Very High Very High
anesthesia 1 94.56 High High
agonist 13 94.00 High High
withdrawal 7 91.64 High High
opiate 10 91.20 High High
Disease Link Frequency Relevance Heat
Depression 5 100.00 Very High Very High Very High
Hypoxia 7 99.92 Very High Very High Very High
Rheumatoid Arthritis 42 99.60 Very High Very High Very High
Cv Unclassified Under Development 1 99.56 Very High Very High Very High
Syndrome 5 98.88 Very High Very High Very High
Shock 4 98.80 Very High Very High Very High
Pain 5 90.80 High High
Opiate Addiction 8 89.72 High High
Fatigue 9 89.52 High High
Cancer 131 86.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The patient was diagnosed as having a partial deficiency of adenine phosphoribosyltransferase (APRT) from the low APRT activity and a genotype of a compound heterozygote APRT*J/APRT*Q0 by T-cell analysis.
Spec (partial) Negative_regulation (deficiency) of APRT in T-cell
1) Confidence 0.57 Published 1998 Journal Hinyokika Kiyo Section Abstract Doc Link 9850838 Disease Relevance 0.25 Pain Relevance 0.08
Relative to the control subjects, patients with RA showed significant reductions of the mean values of F1Amp (-21%, p < 0.001, Fig. 4A), E1Amp (-37%, p < 0.001, Fig. 4A), RI (18%, p < 0.05, Fig. 4B) and ERI (-37%, p < 0.05; Fig. 4B).
Negative_regulation (reductions) of Amp associated with rheumatoid arthritis
2) Confidence 0.57 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693559 Disease Relevance 0.24 Pain Relevance 0.12
From the evidence given, it is concluded that these drugs act by inhibiting brain cyclic AMP phosphodiesterase, thus raising the level of cyclic AMP in appropriate neurons.
Negative_regulation (inhibiting) of AMP in neurons
3) Confidence 0.42 Published 1981 Journal Fed. Proc. Section Abstract Doc Link 6163662 Disease Relevance 0.72 Pain Relevance 1.25
Neonatal PF showed greater depression of AP amp and Vmax during superfusion with the rapid Na+ channel blocker, tetrodotoxin (TTX), than did adult PF.
Negative_regulation (depression) of amp associated with tetrodotoxin, action potential and depression
4) Confidence 0.42 Published 1981 Journal Circ. Res. Section Abstract Doc Link 7214674 Disease Relevance 0.10 Pain Relevance 0.54
Studies of inhibition of the forskolin-stimulated c-AMP formation mediated by the human 5-HT(1B) receptor (formerly the 5-HT(1Dbeta) receptor) demonstrate that all of these serotonin dimers behave as full agonists.
Negative_regulation (inhibition) of AMP associated with agonist and serotonin
5) Confidence 0.41 Published 1996 Journal J. Med. Chem. Section Abstract Doc Link 8960551 Disease Relevance 0 Pain Relevance 0.59
Approximately 1-2% of the Caucasian population are believed to have a skeletal muscle AMP deaminase deficiency [11–13].
Negative_regulation (deficiency) of AMP in skeletal muscle
6) Confidence 0.06 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3005844 Disease Relevance 0.18 Pain Relevance 0.09
AMPK is activated under conditions that deplete cellular ATP and elevate AMP levels such as glucose deprivation, hypoxia, ischemia, and heat shock, which are associated with an increased AMP/ATP ratio [268].
Negative_regulation (deprivation) of AMP associated with hypoxia, ischemia and shock
7) Confidence 0.01 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.19 Pain Relevance 0.11
The Lesch-Nyhan syndrome is an X-linked disorder caused by a virtually complete absence of the key enzyme of purine recycling, hypoxanthine-guanine phosphoribosyltransferase (HPRT).
Negative_regulation (absence) of phosphoribosyltransferase associated with syndrome
8) Confidence 0.01 Published 1999 Journal Metab Brain Dis Section Abstract Doc Link 10850548 Disease Relevance 0.30 Pain Relevance 0.09
In order to resolve whether •OH was involved in the loss of adenine, ethanol or catalase were added separately to adenine/pyrite suspensions.
Negative_regulation (loss) of adenine
9) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0

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