INT41549

Context Info Confidence 0.59 First Reported 1981 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 4.26 Pain Relevance 2.42

extracellular region (B2M) plasma membrane (B2M)

Anatomy Link Frequency urothelial cells 2 BEN 2 urine 2 B2M (Homo sapiens)

Pain Link Frequency Relevance Heat Analgesic 19 99.84 Paracetamol 12 97.96 corticosteroid 3 94.80 aspirin 2 91.12 diclofenac 3 84.40 cINOD 1 78.68 Inflammation 1 78.20

Disease Link Frequency Relevance Heat Malignant Neoplastic Disease 8 99.92 Balkan Nephropathy 6 99.84 Renal Disease 30 99.44 Disorders Of Creatine Metabolism 1 99.24 Cancer 2 99.04 Anuria 1 88.44 Uremia 1 87.72 Congenital Anomalies 2 82.40 Lipoid Nephrosis 1 82.24 INFLAMMATION 1 78.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is suggested that the increased beta 2-microglobulin excretion in analgesic nephropathy is due to secretion from abnormal urothelial cells as well as reduced tubular catabolism.

Positive_regulation (increased) of Localization (excretion) of 2-microglobulin in urothelial cells associated with analgesic and renal disease

1) Confidence 0.59 Published 1982 Journal Clin. Nephrol. Section Abstract Doc Link 6183039 Disease Relevance 1.09 Pain Relevance 0.64

Enhanced secretion of beta 2-microglobulin occurs from epithelial cancer cells.

Positive_regulation (Enhanced) of Localization (secretion) of 2-microglobulin associated with cancer

2) Confidence 0.59 Published 1982 Journal Clin. Nephrol. Section Abstract Doc Link 6183039 Disease Relevance 1.05 Pain Relevance 0.48

Aminoglycosides (tobramycin, UK 18,892) lead to a cumulative increase of the renal excretion of beta 2-microglobulin and AAP while cephalosporins induce an increase of total proteins in the final urine under the same conditions.

Positive_regulation (increase) of Localization (excretion) of 2-microglobulin in urine

3) Confidence 0.06 Published 1981 Journal Contrib Nephrol Section Abstract Doc Link 6164517 Disease Relevance 0.28 Pain Relevance 0.14

In addition, the increased urinary excretion of beta2-microglobulin (beta2MG) and N-acetyl-beta-D-glucosaminidase (NAG) on admission was also improved during the treatment.

Positive_regulation (increased) of Localization (excretion) of beta2-microglobulin

4) Confidence 0.03 Published 2008 Journal Clin. Exp. Nephrol. Section Abstract Doc Link 18274699 Disease Relevance 0.81 Pain Relevance 0.37

Urinary excretion of albumin before acetaminophen treatment was significantly higher in patients with GN and BEN than in healthy adults, however, beta 2-microglobulin excretion was increased in BEN patients only.

Positive_regulation (increased) of Localization (excretion) of 2-microglobulin in BEN associated with paracetamol, balkan nephropathy and renal disease

5) Confidence 0.02 Published 1999 Journal Ren Fail Section Abstract Doc Link 10516997 Disease Relevance 1.02 Pain Relevance 0.79

General Comments

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