INT41549

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Context Info
Confidence 0.59
First Reported 1981
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.26
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (B2M) plasma membrane (B2M)
Anatomy Link Frequency
urothelial cells 2
BEN 2
urine 2
B2M (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 19 99.84 Very High Very High Very High
Paracetamol 12 97.96 Very High Very High Very High
corticosteroid 3 94.80 High High
aspirin 2 91.12 High High
diclofenac 3 84.40 Quite High
cINOD 1 78.68 Quite High
Inflammation 1 78.20 Quite High
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 8 99.92 Very High Very High Very High
Balkan Nephropathy 6 99.84 Very High Very High Very High
Renal Disease 30 99.44 Very High Very High Very High
Disorders Of Creatine Metabolism 1 99.24 Very High Very High Very High
Cancer 2 99.04 Very High Very High Very High
Anuria 1 88.44 High High
Uremia 1 87.72 High High
Congenital Anomalies 2 82.40 Quite High
Lipoid Nephrosis 1 82.24 Quite High
INFLAMMATION 1 78.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that the increased beta 2-microglobulin excretion in analgesic nephropathy is due to secretion from abnormal urothelial cells as well as reduced tubular catabolism.
Positive_regulation (increased) of Localization (excretion) of 2-microglobulin in urothelial cells associated with analgesic and renal disease
1) Confidence 0.59 Published 1982 Journal Clin. Nephrol. Section Abstract Doc Link 6183039 Disease Relevance 1.09 Pain Relevance 0.64
Enhanced secretion of beta 2-microglobulin occurs from epithelial cancer cells.
Positive_regulation (Enhanced) of Localization (secretion) of 2-microglobulin associated with cancer
2) Confidence 0.59 Published 1982 Journal Clin. Nephrol. Section Abstract Doc Link 6183039 Disease Relevance 1.05 Pain Relevance 0.48
Aminoglycosides (tobramycin, UK 18,892) lead to a cumulative increase of the renal excretion of beta 2-microglobulin and AAP while cephalosporins induce an increase of total proteins in the final urine under the same conditions.
Positive_regulation (increase) of Localization (excretion) of 2-microglobulin in urine
3) Confidence 0.06 Published 1981 Journal Contrib Nephrol Section Abstract Doc Link 6164517 Disease Relevance 0.28 Pain Relevance 0.14
In addition, the increased urinary excretion of beta2-microglobulin (beta2MG) and N-acetyl-beta-D-glucosaminidase (NAG) on admission was also improved during the treatment.
Positive_regulation (increased) of Localization (excretion) of beta2-microglobulin
4) Confidence 0.03 Published 2008 Journal Clin. Exp. Nephrol. Section Abstract Doc Link 18274699 Disease Relevance 0.81 Pain Relevance 0.37
Urinary excretion of albumin before acetaminophen treatment was significantly higher in patients with GN and BEN than in healthy adults, however, beta 2-microglobulin excretion was increased in BEN patients only.
Positive_regulation (increased) of Localization (excretion) of 2-microglobulin in BEN associated with paracetamol, balkan nephropathy and renal disease
5) Confidence 0.02 Published 1999 Journal Ren Fail Section Abstract Doc Link 10516997 Disease Relevance 1.02 Pain Relevance 0.79

General Comments

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