INT41555

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Context Info
Confidence 0.52
First Reported 1980
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 10.94
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRN) mitochondrion (GRN) extracellular space (GRN)
extracellular region (GRN)
Anatomy Link Frequency
gut 1
GRN (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 319 99.96 Very High Very High Very High
Dopamine 15 97.04 Very High Very High Very High
Inflammation 15 96.44 Very High Very High Very High
Angina 2 80.72 Quite High
Enkephalin 1 80.56 Quite High
substance P 1 80.08 Quite High
positron emission tomography 2 12.48 Low Low
imagery 18 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 428 100.00 Very High Very High Very High
Metastasis 48 99.36 Very High Very High Very High
Syndrome 45 99.28 Very High Very High Very High
Glucagonoma 18 98.92 Very High Very High Very High
Injury 15 97.00 Very High Very High Very High
Diarrhoea 30 96.96 Very High Very High Very High
INFLAMMATION 15 96.44 Very High Very High Very High
Vipoma 3 96.32 Very High Very High Very High
Lung Cancer 31 94.68 High High
Carcinoid 66 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GEP (Gene expression programming) is a new genetic algorithm, and it has been proved to be excellent in function finding.
Gene_expression (expression) of GEP
1) Confidence 0.52 Published 2009 Journal Sheng Wu Yi Xue Gong Cheng Xue Za Zhi Section Abstract Doc Link 19334550 Disease Relevance 0.32 Pain Relevance 0.16
The purpose of this pilot study was to compare GEP profiles from needle biopsies to GEP profiles from the resected tumor in the same cohort of patients.


Gene_expression (profiles) of GEP associated with cancer
2) Confidence 0.33 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717848 Disease Relevance 1.21 Pain Relevance 0
Classical gene expression profiling (GEP) requires a tissue sample from the tumor, RNA extraction, and DNA hybridization to determine which genes are expressed in a given tumor.
Gene_expression (expression) of GEP associated with cancer
3) Confidence 0.33 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717848 Disease Relevance 1.61 Pain Relevance 0
Around 80% of GEP NETs express somatostatin receptors (SSTRs), located on the cell membrane.
Gene_expression (express) of GEP associated with somatostatin
4) Confidence 0.27 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 1.90 Pain Relevance 0.05
However, 90% of GEP NETs do not produce biologically active hormones (non functioning tumours) and therefore the diagnosis is often made too late, in presence of symptoms due to the mass effect and/or the presence of metastases, mainly hepatic metastases [1].
Neg (not) Gene_expression (produce) of GEP associated with cancer and metastasis
5) Confidence 0.27 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 2.81 Pain Relevance 0
In a study examining 81 functioning and non-functioning GEP NETs the large parte of the tumours expressed SSTRs 1, 2, 3 and 5, while SSTR 4 was detected only in a small minority [10].
Gene_expression (expressed) of GEP associated with cancer
6) Confidence 0.23 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 1.03 Pain Relevance 0.24
The same amount of RNA was used for the GEP analysis of each sample.
Gene_expression (analysis) of GEP
7) Confidence 0.16 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779463 Disease Relevance 0 Pain Relevance 0
A GEP detected in a CB are representative for the entire tumor and is, therefore, of clinical relevance.
Gene_expression (detected) of GEP associated with cancer
8) Confidence 0.14 Published 2006 Journal Breast Cancer Res Section Abstract Doc Link PMC1779463 Disease Relevance 1.04 Pain Relevance 0.05
In 82% of the cases the GEP detected in the CB correlated very well with the corresponding profile in the surgical sample (rs ?
Gene_expression (detected) of GEP
9) Confidence 0.14 Published 2006 Journal Breast Cancer Res Section Abstract Doc Link PMC1779463 Disease Relevance 1.02 Pain Relevance 0.04
The observations support the hypothesis that neuronal GEP hormonal peptide production in the brain is a genuinely original mechanism and the appearance of endocrine cells in the gut a later feature in evolution.
Gene_expression (production) of GEP in gut
10) Confidence 0.02 Published 1980 Journal Regul. Pept. Section Abstract Doc Link 6165052 Disease Relevance 0 Pain Relevance 0.16

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