INT41557

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Context Info
Confidence 0.68
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 8
Disease Relevance 1.17
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Sp1) nucleus (Sp1) intracellular (Sp1)
DNA binding (Sp1) transcription factor binding (Sp1) cytoplasm (Sp1)
Anatomy Link Frequency
motor neurons 1
Sp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 9 100.00 Very High Very High Very High
substance P 6 100.00 Very High Very High Very High
mu opioid receptor 8 99.24 Very High Very High Very High
cINOD 10 97.52 Very High Very High Very High
qutenza 5 92.24 High High
Dorsal horn 1 91.80 High High
Spinal cord 126 91.08 High High
metalloproteinase 2 80.96 Quite High
opioid receptor 1 75.00 Quite High
tetrodotoxin 1 74.64 Quite High
Disease Link Frequency Relevance Heat
Pain 9 100.00 Very High Very High Very High
Injury 264 95.72 Very High Very High Very High
Lung Cancer 1 83.88 Quite High
Repression 13 82.40 Quite High
INFLAMMATION 14 79.04 Quite High
Neurodegenerative Disease 4 70.76 Quite High
Embryonal Carcinoma 1 70.68 Quite High
Nervous System Malformation 4 44.48 Quite Low
Spasticity 72 18.12 Low Low
Spinal Cord Injury 76 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This database is at present not fully annotated for all know transcriptions factors, and at the time of writing TRANSFAC contained motifs for 6 of the 34 transcription factors encoded by genes identified in the present study as differentially expressed (SP1, E2F1, FOXO1, ATF3, ATF4, MYC).
Gene_expression (expressed) of SP1
1) Confidence 0.68 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.25 Pain Relevance 0
The differentially expressed genes of SP1 (Sp1) and E2F1 (E2f1) belong to cluster 7, which show an early up-regulation that is maintained throughout the injury response.
Gene_expression (expressed) of SP1 associated with injury
2) Confidence 0.68 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.10 Pain Relevance 0
The differentially expressed genes of SP1 (Sp1) and E2F1 (E2f1) belong to cluster 7, which show an early up-regulation that is maintained throughout the injury response.
Gene_expression (expressed) of Sp1 associated with injury
3) Confidence 0.68 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.10 Pain Relevance 0
The expression pattern of the genes coding for SP1, E2F1 and MYC together with their broad cluster targets suggest that these un-specific activators of transcription enhance the general transcriptional capacity of the motor neurons, while the expression pattern of genes coding for other more specific regulators of transcription like OLIG1 or NKX6-2 could function to shape the response by relief or activation of targeted suppression of specific sets of genes, supporting the hypothesis of suppressor mediated transcriptional specificity.
Gene_expression (expression) of SP1 in motor neurons
4) Confidence 0.52 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.23 Pain Relevance 0
Sp1 overexpression studies also led to increases in cytochrome c transactivation and mRNA levels.
Gene_expression (overexpression) of Sp1
5) Confidence 0.23 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11279044 Disease Relevance 0 Pain Relevance 0.07
A positive correlation was found between the I-SP releasing and pain-producing potencies of these compounds.
Gene_expression (producing) of I-SP associated with pain and substance p
6) Confidence 0.19 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6165593 Disease Relevance 0.10 Pain Relevance 0.75
Overexpression of Sp1 strongly enhanced MOR promoter activity, and the histone deacetylase inhibitor trichostatin A also increased promoter activity.
Gene_expression (Overexpression) of Sp1 associated with mu opioid receptor
7) Confidence 0.17 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20385708 Disease Relevance 0.07 Pain Relevance 0.36
Electrophoretic mobility shift assays show that Sp1 and Sp3 proteins constitutively bind to this consensus sequence and overexpression of Sp1 may enhance MMP-2 expression.
Gene_expression (overexpression) of Sp1
8) Confidence 0.16 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12087091 Disease Relevance 0.32 Pain Relevance 0.85

General Comments

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