INT41558

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 1981
Last Reported 1982
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 12
Disease Relevance 0.56
Pain Relevance 14.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Sp1) nucleus (Sp1) intracellular (Sp1)
DNA binding (Sp1) transcription factor binding (Sp1) cytoplasm (Sp1)
Anatomy Link Frequency
UDH 4
spinal cord 2
primary sensory neurons 1
Sp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 112 100.00 Very High Very High Very High
Somatostatin 12 100.00 Very High Very High Very High
qutenza 120 99.84 Very High Very High Very High
Dorsal horn 32 99.76 Very High Very High Very High
Spinal cord 26 99.60 Very High Very High Very High
intrathecal 8 98.74 Very High Very High Very High
Sciatic nerve 8 98.68 Very High Very High Very High
Pain 12 93.64 High High
withdrawal 16 90.80 High High
narcan 4 87.20 High High
Disease Link Frequency Relevance Heat
Pain 8 93.64 High High
Nociception 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After treatment of adult mice release of I-SP was reduced by 93%.
Localization (release) of I-SP associated with substance p
1) Confidence 0.48 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6182473 Disease Relevance 0.07 Pain Relevance 1.44
Capsaicin-evoked release of I-SP from rat spinal cord was reduced by 93% after neonatal treatment, but only by 69% 2 weeks after adult treatment.
Localization (release) of I-SP in spinal cord associated with qutenza, spinal cord and substance p
2) Confidence 0.48 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6182473 Disease Relevance 0.07 Pain Relevance 1.34
Treatment of mice on day 2 caused a similar decrease of the I-SP content in spinal cord and of the capsaicin-evoked I-SP release (88%) as treatment on day 4 or 7 although behavioral changes were different.
Localization (release) of I-SP in spinal cord associated with qutenza, spinal cord and substance p
3) Confidence 0.48 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6182473 Disease Relevance 0.07 Pain Relevance 1.40
The effect of systemic or intrathecal treatment on thermonociception, chemonociception, content and release of immunoreactive substance P (I-SP) was investigated.
Localization (release) of I-SP associated with substance p and intrathecal
4) Confidence 0.48 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6182473 Disease Relevance 0.07 Pain Relevance 0.47
Capsaicin and its congeners were all able to stimulate I-SP release, indicating that they act on chemosensitive primary afferents terminating in this region.
Localization (release) of I-SP associated with qutenza and substance p
5) Confidence 0.26 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6165593 Disease Relevance 0.09 Pain Relevance 0.76
The in vitro release of immunoreactive substance P (I-SP) by capsaicin and three congeners was studied on slices of rat spinal cord upper dorsal horn.
Localization (release) of I-SP in dorsal horn associated with qutenza, dorsal horn, spinal cord and substance p
6) Confidence 0.23 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6165593 Disease Relevance 0.07 Pain Relevance 0.73
A pulse of 60 mM K+ applied after the capsaicin pulse caused release of I-SRIF and I-SP from UDH as well as LDH-VH slices.
Localization (release) of I-SP in UDH associated with qutenza, dorsal horn and substance p
7) Confidence 0.06 Published 1981 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6168921 Disease Relevance 0 Pain Relevance 1.58
Superfusion with capsaicin (10 microM) led to release of I-SRIF and I-SP from UDH slices but not from LDH-VH slices.
Localization (release) of I-SP in UDH associated with qutenza, dorsal horn and substance p
8) Confidence 0.05 Published 1981 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6168921 Disease Relevance 0 Pain Relevance 1.36
The capsaicin-evoked release of I-SP was 6 fold higher than that of I-SRIF.
Localization (release) of I-SP associated with qutenza and substance p
9) Confidence 0.05 Published 1981 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6168921 Disease Relevance 0 Pain Relevance 1.42
Release of immunoreactive somatostatin (I-SRIF) and immunoreactive substance P (I-SP) was studied from slices prepared from upper dorsal horn (UDH) and lower dorsal plus ventral horn (LDH-VH) of rat spinal cord.
Localization (Release) of I-SP in UDH associated with dorsal horn, somatostatin, spinal cord and substance p
10) Confidence 0.05 Published 1981 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6168921 Disease Relevance 0 Pain Relevance 1.12
These results indicate that capsaicin causes release of both I-SRIF and-I-SP and that this release is most likely restricted to primary sensory neurons.
Localization (release) of I-SP in primary sensory neurons associated with qutenza and substance p
11) Confidence 0.05 Published 1981 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6168921 Disease Relevance 0 Pain Relevance 1.65
The marked reduction of the release of I-SP after systemic capsaicin pretreatment may well represent one of the, or even the reason for the insensitivity of capsaicin pretreated rats towards chemogenic pain.
Localization (release) of I-SP associated with pain, qutenza and substance p
12) Confidence 0.05 Published 1981 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6168921 Disease Relevance 0.09 Pain Relevance 1.63

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox