INT41559

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Context Info
Confidence 0.45
First Reported 1981
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.65
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Sp1) nucleus (Sp1) intracellular (Sp1)
DNA binding (Sp1) transcription factor binding (Sp1) cytoplasm (Sp1)
Anatomy Link Frequency
muscle cells 1
Sp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 6 100.00 Very High Very High Very High
fluoxetine 11 99.72 Very High Very High Very High
qutenza 5 99.28 Very High Very High Very High
agonist 19 99.24 Very High Very High Very High
Dorsal horn 1 98.12 Very High Very High Very High
Spinal cord 2 97.40 Very High Very High Very High
tetrodotoxin 5 97.32 Very High Very High Very High
nociceptor 3 95.52 Very High Very High Very High
cytokine 28 95.28 Very High Very High Very High
Inflammatory mediators 3 89.52 High High
Disease Link Frequency Relevance Heat
Nociception 4 100.00 Very High Very High Very High
Repression 2 99.68 Very High Very High Very High
Stress 12 97.64 Very High Very High Very High
Apoptosis 13 95.48 Very High Very High Very High
Arthritis 127 92.64 High High
INFLAMMATION 92 89.52 High High
Pain 3 86.96 High High
Cholestasis 33 82.08 Quite High
Infection 4 75.92 Quite High
Obstructive Jaundice 5 74.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, c-FLIP induction by fluoxetine requires the activation of the c-FLIP promoter region spanning nucleotides -414 to -133, including CREB and SP1 sites.
Positive_regulation (activation) of SP1 associated with fluoxetine
1) Confidence 0.45 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16545775 Disease Relevance 0.24 Pain Relevance 1.09
Based on the threshold and the onset latency we conclude that at least SP1 and laser SP are nociceptive in origin and mediated by group III fibers.
Positive_regulation (mediated) of SP1 associated with nociception
2) Confidence 0.36 Published 1997 Journal Brain Res. Section Abstract Doc Link 9295212 Disease Relevance 0.30 Pain Relevance 0.30
This was paralleled by increases in Sp1 protein levels.
Positive_regulation (increases) of Sp1
3) Confidence 0.24 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11279044 Disease Relevance 0 Pain Relevance 0.08
Capsaicin and its congeners were all able to stimulate I-SP release, indicating that they act on chemosensitive primary afferents terminating in this region.
Positive_regulation (stimulate) of I-SP associated with qutenza and substance p
4) Confidence 0.19 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6165593 Disease Relevance 0.09 Pain Relevance 0.76
Contractile activity-induced transcriptional activation of cytochrome C involves Sp1 and is proportional to mitochondrial ATP synthesis in C2C12 muscle cells.
Positive_regulation (involves) of Sp1 in muscle cells
5) Confidence 0.17 Published 2001 Journal J. Biol. Chem. Section Title Doc Link 11279044 Disease Relevance 0 Pain Relevance 0.05
These data reveal a possible involvement of PLD, c-jun N-terminal kinase, PKCzeta and Sp1 in the repression of AChR genes by electrical activity.
Spec (possible) Positive_regulation (involvement) of Sp1 associated with repression
6) Confidence 0.12 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11163354 Disease Relevance 0.18 Pain Relevance 0.25
In the presence of extrahepatic biliary obstruction, the activation of p38, c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) considered 'stress kinases' [108] would be produced. p38 MAP kinase in particular has been suggested to regulate IL10 synthesis through activation of Sp1 transcription factor rather than through the NF?
Positive_regulation (activation) of Sp1 transcription factor associated with stress
7) Confidence 0.04 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.98 Pain Relevance 0.22
PPARs are ligand-inducible nuclear trans-acting factors belonging to the steroid receptors family [11].
Positive_regulation (inducible) of trans-acting
8) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 0.85 Pain Relevance 0.50

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