INT41569

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Context Info
Confidence 0.62
First Reported 1981
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 32
Total Number 34
Disease Relevance 17.15
Pain Relevance 9.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
cleavage 2
brain 2
macrophage 1
PC-12 1
dorsal 1
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 128 100.00 Very High Very High Very High
agonist 10 100.00 Very High Very High Very High
cytokine 12 99.90 Very High Very High Very High
cINOD 90 99.88 Very High Very High Very High
Inflammation 120 99.70 Very High Very High Very High
qutenza 1 99.58 Very High Very High Very High
dorsal rhizotomy 1 99.28 Very High Very High Very High
tolerance 5 99.24 Very High Very High Very High
tetrodotoxin 4 98.40 Very High Very High Very High
Central nervous system 12 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 229 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 6 100.00 Very High Very High Very High
Disease 482 99.98 Very High Very High Very High
INFLAMMATION 148 99.70 Very High Very High Very High
Systemic Lupus Erythematosus 5 97.96 Very High Very High Very High
Infection 7 97.48 Very High Very High Very High
Cancer 21 96.48 Very High Very High Very High
Necrosis 2 96.00 Very High Very High Very High
Apoptosis 7 94.24 High High
Syndrome 8 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels.
Regulation (regulates) of Abeta associated with alzheimer's dementia and abeta
1) Confidence 0.62 Published 2009 Journal J. Neurochem. Section Title Doc Link 19702658 Disease Relevance 0.54 Pain Relevance 0.69
For example, several studies show that only a few selected NSAIDs also affect beta-amyloid (Abeta) deposition and metabolism.
Regulation (affect) of Abeta associated with alzheimer's dementia, cinod and abeta
2) Confidence 0.60 Published 2005 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 15850679 Disease Relevance 1.30 Pain Relevance 0.89
The methodology recapitulated reported results for modulation of Abeta by GSMs.
Regulation (modulation) of Abeta associated with abeta
3) Confidence 0.54 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19702658 Disease Relevance 0.46 Pain Relevance 0.85
All mutations described in the rare autosomal-dominant forms of AD affect APP and ?
Regulation (affect) of APP associated with disease
4) Confidence 0.50 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866463 Disease Relevance 1.49 Pain Relevance 0
In this particular study our investigation was limited to APP-Notch2 heterodimers; however, this is likely only a small proportion of the total population of APP heterodimers, and it is possible that OSBP1 could also affect the intracellular trafficking of other types of APP heterodimers.
Regulation (population) of APP
5) Confidence 0.44 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.07 Pain Relevance 0
According to this hypothesis, both cholesterol and the examined compounds stimulated the beta-secretase cleavage of APP, resulting in a massive increase of secreted amyloid-beta peptides.
Regulation (stimulated) of APP in cleavage associated with alzheimer's dementia
6) Confidence 0.44 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17395689 Disease Relevance 0.57 Pain Relevance 0.10
To determine whether additional cell-surface receptor types linked to this signal transduction pathway could also regulate APP processing, we stimulated differentiated PC-12 cells with bradykinin and found that this neuropeptide also increased the secretion of amino-terminal APP derivatives.
Regulation (regulate) of APP in PC-12 associated with neuropeptide and bradykinin
7) Confidence 0.40 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8239269 Disease Relevance 0.13 Pain Relevance 0.27
Several studies have examined the effect of LXR agonists on APP processing [19,38,39].
Spec (examined) Regulation (effect) of APP associated with agonist
8) Confidence 0.38 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.19 Pain Relevance 0.05
His research on the neuropathogenesis of Alzheimer's disease has focused primarily on the molecular mechanisms underlying beta-amyloid precursor protein processing and beta-amyloid protein production, especially regarding regulation of the gamma-secretase complex.Additionally, his work has addressed the role of presenilin-related apoptosis in Alzheimer's disease.
Regulation (underlying) of beta-amyloid protein associated with alzheimer's dementia, apoptosis and disease
9) Confidence 0.38 Published 2005 Journal J. Mol. Neurosci. Section Abstract Doc Link 15781967 Disease Relevance 0.67 Pain Relevance 0.08
Strong opponents of the hypothesis now include Mark Smith and George Perry, who have criticized the field as being too “amyloidocentric” [10, 11], emphasized oxidative damage and cited data reporting amyloid precursor protein (APP) [12] or A?
Regulation (reporting) of amyloid precursor protein associated with alzheimer's dementia
10) Confidence 0.35 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.97 Pain Relevance 0
Strong opponents of the hypothesis now include Mark Smith and George Perry, who have criticized the field as being too “amyloidocentric” [10, 11], emphasized oxidative damage and cited data reporting amyloid precursor protein (APP) [12] or A?
Regulation (reporting) of APP associated with alzheimer's dementia
11) Confidence 0.35 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.97 Pain Relevance 0
In order to investigate whether cell-surface receptor activity can regulate APP processing, HEK 293 cell lines stably expressing human muscarinic acetylcholine receptors (mAChR; subtypes m1, m2, m3, m4) were stimulated with the muscarinic agonist carbachol, and the release of APP derivatives was measured.
Regulation (regulate) of APP associated with agonist
12) Confidence 0.35 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8239269 Disease Relevance 0.16 Pain Relevance 0.07
Here we present evidence that inflammatory cytokines can alter the metabolism of the beta-amyloid precursor protein (betaAPP).
Regulation (alter) of beta-amyloid precursor protein associated with inflammation, alzheimer's dementia and cytokine
13) Confidence 0.30 Published 1999 Journal FASEB J. Section Abstract Doc Link 9872930 Disease Relevance 1.20 Pain Relevance 0.32
Here, we show that several fibrates and diaryl heterocycle cyclooxygenase inhibitors, among them the commonly used drugs fenofibrate and celecoxib, exhibit effects similar to those of cholesterol on cellular membranes and amyloid precursor protein (APP) processing.
Regulation (effects) of amyloid precursor protein associated with alzheimer's dementia
14) Confidence 0.26 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17395689 Disease Relevance 0.45 Pain Relevance 0
Here, we show that several fibrates and diaryl heterocycle cyclooxygenase inhibitors, among them the commonly used drugs fenofibrate and celecoxib, exhibit effects similar to those of cholesterol on cellular membranes and amyloid precursor protein (APP) processing.
Regulation (effects) of APP associated with alzheimer's dementia
15) Confidence 0.26 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17395689 Disease Relevance 0.45 Pain Relevance 0
The results confirmed that modulation of Abeta(1-40)/Abeta(1-42) was mediated by selective proteolysis.
Regulation (modulation) of Abeta associated with abeta
16) Confidence 0.24 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19702658 Disease Relevance 0.37 Pain Relevance 0.86
The results confirmed that modulation of Abeta(1-40)/Abeta(1-42) was mediated by selective proteolysis.
Regulation (modulation) of Abeta associated with abeta
17) Confidence 0.24 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19702658 Disease Relevance 0.37 Pain Relevance 0.86
However, control experiments in which exogenous Abeta(1-40)/Abeta(1-42) was added (i) to drug-treated wild-type cells or (ii) to conditioned media from these wild-type cells, gave comparable patterns of Abeta modulation.
Regulation (modulation) of Abeta associated with abeta
18) Confidence 0.24 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19702658 Disease Relevance 0.42 Pain Relevance 0.89
In addition, non-steroidal anti-inflammatory drugs (NSAIDs) and HMG-CoA reductase inhibitors (statins), two classes of drugs reported to affect APP processing and Abeta formation in Alzheimer's disease, have been evaluated for their capacity to inhibit macrophage activation evoked by platelet phagocytosis.
Regulation (affect) of APP in macrophage associated with inflammation, cinod, disease and abeta
19) Confidence 0.24 Published 2006 Journal Cardiovascular & hematological disorders drug targets Section Abstract Doc Link 16724933 Disease Relevance 0.99 Pain Relevance 0.49
In support of this hypothesis, the CH25H gene encoding for cholesterol 25-hydroxylase and located within the major AD-linkage region of chromosome 10, is ranked third in a list of genes with strongest association with the disease [40]. 25OH-mediated activation of ORPs would likely result in a distinct modulation of APP processing than that of LXRs, since ORPs regulate cholesterol distribution and organelle trafficking, while LXRs are transcription factors which primarily induce genes involved in cholesterol efflux [41,42].
Regulation (modulation) of APP associated with disease
20) Confidence 0.23 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.19 Pain Relevance 0.04

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