INT4159

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Context Info
Confidence 0.72
First Reported 1976
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 33
Total Number 34
Disease Relevance 12.49
Pain Relevance 8.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hp) extracellular region (Hp) Golgi apparatus (Hp)
endoplasmic reticulum (Hp) response to stress (Hp)
Anatomy Link Frequency
plasma 4
liver 2
radial 1
muscles 1
platelet 1
Hp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 252 100.00 Very High Very High Very High
primary somatosensory cortex 200 100.00 Very High Very High Very High
Dopamine 8 100.00 Very High Very High Very High
lidocaine 22 99.84 Very High Very High Very High
anesthesia 10 99.82 Very High Very High Very High
analgesia 5 99.60 Very High Very High Very High
Inflammation 119 98.88 Very High Very High Very High
qutenza 3 98.52 Very High Very High Very High
Nicotine 4 98.40 Very High Very High Very High
abdominal pain 10 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 39 100.00 Very High Very High Very High
Infection 12 100.00 Very High Very High Very High
Ulcers 11 100.00 Very High Very High Very High
Gastritis 5 100.00 Very High Very High Very High
Neurological Disease 2 99.30 Very High Very High Very High
Diabetes Mellitus 62 99.28 Very High Very High Very High
Syndrome 6 99.24 Very High Very High Very High
Obesity 8 99.20 Very High Very High Very High
Myocardial Infarction 2 99.08 Very High Very High Very High
INFLAMMATION 122 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Haptoglobin (Hp) is an acute-phase protein synthesized in the liver that circulates at elevated concentrations in response to tissue damage caused by inflammation, infection, and trauma.
Gene_expression (synthesized) of Hp in liver associated with inflammation, injury and infection
1) Confidence 0.72 Published 2007 Journal J. Wildl. Dis. Section Abstract Doc Link 17495310 Disease Relevance 0.29 Pain Relevance 0.05
Haptoglobin (Hp) is an acute-phase protein synthesized in the liver that circulates at elevated concentrations in response to tissue damage caused by inflammation, infection, and trauma.
Gene_expression (synthesized) of Haptoglobin in liver associated with inflammation, injury and infection
2) Confidence 0.72 Published 2007 Journal J. Wildl. Dis. Section Abstract Doc Link 17495310 Disease Relevance 0.29 Pain Relevance 0.05
These data suggest that part of nicotine's discriminative stimulus properties may be contingent upon the integrity of a Hp-DA connection.
Gene_expression (connection) of Hp-DA associated with dopamine and nicotine
3) Confidence 0.67 Published 1976 Journal Psychopharmacol Commun Section Abstract Doc Link 996286 Disease Relevance 0 Pain Relevance 0.63
[Determination of serum haptoglobin concentration in the acute phase of myocardial infarct by means of Mancini's simple radial immunodiffusion test].
Gene_expression (concentration) of haptoglobin in radial associated with myocardial infarction
4) Confidence 0.66 Published 1981 Journal Z Gesamte Inn Med Section Title Doc Link 6805142 Disease Relevance 0.65 Pain Relevance 0.31
There was no correlation between Hp levels and platelet count (P = 0.095) or hemoglobin (P = 0.457).
Gene_expression (levels) of Hp in platelet
5) Confidence 0.63 Published 2007 Journal J. Wildl. Dis. Section Abstract Doc Link 17495310 Disease Relevance 0.29 Pain Relevance 0.16
[Haptoglobin determination in the serum of patients following intraoperative autotransfusion using the Haemonetics Cell Saver III.
Gene_expression (determination) of Haptoglobin
6) Confidence 0.50 Published 1988 Journal Anaesthesist Section Title Doc Link 3218723 Disease Relevance 0.22 Pain Relevance 0.06
Routine blubber biopsies collected under gas anesthesia did not produce a measurable Hp response.
Neg (not) Gene_expression (produce) of Hp associated with anesthesia
7) Confidence 0.49 Published 2007 Journal J. Wildl. Dis. Section Abstract Doc Link 17495310 Disease Relevance 0.29 Pain Relevance 0.17
The serum samples were used to determine the levels of haptoglobin, ?
Spec (determine) Gene_expression (levels) of haptoglobin
8) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174937 Disease Relevance 0.33 Pain Relevance 0.13
As shown in Fig. 3, both haptoglobin and ?
Gene_expression (shown) of haptoglobin
9) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174937 Disease Relevance 0.24 Pain Relevance 0.05
The activity of WAY-169916 is related to its ability to suppress inflammatory processes globally, as demonstrated by the decrease in serum acute-phase protein levels of haptoglobin, ?
Gene_expression (levels) of haptoglobin associated with inflammation
10) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174937 Disease Relevance 1.15 Pain Relevance 0.51
Fgf2, haptoglobin, and IL-4 levels were elevated in diabetic animals, while IL-17 levels were significantly decreased in diabetic levels.
Gene_expression (levels) of haptoglobin associated with diabetes mellitus
11) Confidence 0.19 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.90 Pain Relevance 0.05
Free radicals in inflammatory neurological disease: increased lipid peroxidation and haptoglobin levels in Guillain Barré syndrome.
Gene_expression (levels) of haptoglobin associated with neurological disease, inflammation and syndrome
12) Confidence 0.18 Published 1998 Journal Ir J Med Sci Section Title Doc Link 9540301 Disease Relevance 1.21 Pain Relevance 0.36
Normalized IEG expression levels in HP did not vary significantly across states.
Gene_expression (expression) of HP associated with hippocampus
13) Confidence 0.16 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.23 Pain Relevance 0.63
There were no differences (P > .05) between CON and CORT animals in IFN-gamma production, haptoglobin, fibrinogen, ADG, and ADFI.
Gene_expression (production) of haptoglobin
14) Confidence 0.15 Published 1997 Journal J. Anim. Sci. Section Abstract Doc Link 9110218 Disease Relevance 0.12 Pain Relevance 0.09
Keyhole limpet hemocyanin (KLH)- and concanavalin A (Con A)-induced in vitro IFN-gamma production in blood, and plasma haptoglobin and fibrinogen were measured in blood samples taken before treatment on d 0 and on d 1 and 3.
Gene_expression (production) of haptoglobin in plasma
15) Confidence 0.15 Published 1997 Journal J. Anim. Sci. Section Abstract Doc Link 9110218 Disease Relevance 0.15 Pain Relevance 0.11
Next, we compared the mean firing rates of activated neurons in S1, HP, and V1 across WK, SWS, and REM sleep occurring between 2?
Gene_expression (neurons) of HP in neurons associated with primary somatosensory cortex and hippocampus
16) Confidence 0.14 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0 Pain Relevance 0.18
Our results suggest that IEG expression is more strongly coupled to LFPs in S1 than in HP.
Gene_expression (expression) of HP associated with primary somatosensory cortex and hippocampus
17) Confidence 0.14 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.06 Pain Relevance 0.21
0.23 in HP; for Zif-268, H?
Gene_expression (0.23) of HP associated with hippocampus
18) Confidence 0.14 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.25 Pain Relevance 0.71
The objective of this study was to determine the effects of castration, with its presumed pain and inflammatory effects, including increased cortisol, and elevated cortisol per se on in vitro interferon-gamma (IFN-gamma) production, ADG, ADFI, and plasma haptoglobin and fibrinogen.
Gene_expression (production) of haptoglobin in plasma associated with pain and inflammation
19) Confidence 0.12 Published 1997 Journal J. Anim. Sci. Section Abstract Doc Link 9110218 Disease Relevance 0.20 Pain Relevance 0.15
These results indicate that for both routes of spinal administration, the complexation of sufentanil plus bupivacaine in HP-B-CD can produce a longer analgesia than either plain sufentanil, sufentanil combined with bupivacaine or sufentanil alone in HP-B-CD.
Gene_expression (produce) of HP-B-CD in spinal associated with analgesia
20) Confidence 0.11 Published 1992 Journal Acta Anaesthesiol Belg Section Abstract Doc Link 1385920 Disease Relevance 0 Pain Relevance 0.72

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