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Context Info
Confidence 0.42
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.10
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PAX5) nucleus (PAX5) DNA binding (PAX5)
Anatomy Link Frequency
muscles 1
Urine 1
PAX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Facet joint 1 96.56 Very High Very High Very High
fibrosis 1 90.80 High High
Pain 4 88.44 High High
addiction 2 87.96 High High
backache 2 86.20 High High
headache 188 82.92 Quite High
Arthritis 7 77.28 Quite High
abdominal pain 1 59.92 Quite High
Osteoarthritis 57 56.96 Quite High
withdrawal 5 45.44 Quite Low
Disease Link Frequency Relevance Heat
Fasciculation 1 97.56 Very High Very High Very High
Skin Cancer 4 97.32 Very High Very High Very High
Sclerosis 2 96.96 Very High Very High Very High
Hypercalcemia 68 96.08 Very High Very High Very High
Disorder Of Lipid Metabolism 5 94.32 High High
Obesity 20 94.08 High High
Malignant Neoplastic Disease 1 92.84 High High
Fibrosis 1 90.80 High High
Pressure And Volume Under Development 4 90.28 High High
Pain 3 88.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EMG in proximal muscles showed decreased duration and voltage of potentials, excess of short polyphasics and increased recruitment (BSAP), with positive waves and fibrillations; distal muscles had fasciculations, fibrillations, positive waves, normal voluntary potentials, decreased recruitment.
Positive_regulation (increased) of BSAP in muscles associated with fasciculation
1) Confidence 0.42 Published 1981 Journal Arq Neuropsiquiatr Section Abstract Doc Link 6167247 Disease Relevance 0.67 Pain Relevance 0.26
Both treatments positively affected markers of bone formation as indicated by increased serum bone-specific alkaline phosphatase (BSAP) activity, insulin-like growth factor-I (IGF-I), and osteocalcin (BSAP: 27.8 and 25.8%, IGF-I: 12.8 and 26.3%, osteocalcin: 95.2 and 103.4% for control and soy groups, respectively).
Positive_regulation (increased) of BSAP
2) Confidence 0.33 Published 2005 Journal Nutr J Section Abstract Doc Link PMC554088 Disease Relevance 0.20 Pain Relevance 0
In the present study, biomarkers of bone formation, i.e. osteocalcein, IGF-I, and BSAP were all significantly elevated in both groups.
Positive_regulation (elevated) of BSAP
3) Confidence 0.33 Published 2005 Journal Nutr J Section Body Doc Link PMC554088 Disease Relevance 0.22 Pain Relevance 0
In contrast, we observed that treatment with ISMO resulted in significant increases in BSAP.
Positive_regulation (increases) of BSAP
4) Confidence 0.32 Published 2006 Journal Trials Section Body Doc Link PMC1471803 Disease Relevance 0.23 Pain Relevance 0.23
For Ln-BSAP, there was a modest nonsignificant association, with the odds of a BML being present increasing 1.4-fold per 1 standard deviation increase in the Ln-BSAP.
Positive_regulation (increase) of BSAP
5) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.23 Pain Relevance 0.03
Urine NTx and BSAP remained suppressed with continuous alendronate, but increased by about 25% when treatment was discontinued although they remained below baseline for the 5 years of observation
Positive_regulation (increased) of BSAP in Urine
6) Confidence 0.31 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936260 Disease Relevance 0.10 Pain Relevance 0.05
D-003 (10 mg/day) lowered urinary excretion of tDPD/Cr versus baseline (20.6%) (p < 0.001) and placebo (33.7%) (p < 0.01), but did not modify serum BSAP.
Neg (not) Positive_regulation (modify) of BSAP
7) Confidence 0.27 Published 2005 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 16402634 Disease Relevance 0.72 Pain Relevance 0.06
We found that, compared with placebo, women randomized to intermittent ISMO at 20 mg had a 45.4% decrease in NTx (95% confidence interval [CI]: 25.8 to 64.9) and a 23.3% increase (95% CI: 8.9 to 37.8) in BSAP.
Positive_regulation (increase) of BSAP
8) Confidence 0.22 Published 2006 Journal Trials Section Body Doc Link PMC1471803 Disease Relevance 0.07 Pain Relevance 0
After six months, women taking NTG ointment had a 40% decrease in NTx and 25% increase in BSAP compared with baseline.
Positive_regulation (increase) of BSAP
9) Confidence 0.22 Published 2006 Journal Trials Section Body Doc Link PMC1471803 Disease Relevance 0.39 Pain Relevance 0.28
It has also been shown that translation of COX-2 mRNA requires the activity of the eIF-5A transcription factor (Parker and Gerner, 2002), the inhibition of which impairs murine melanoma growth (Jasiulionis et al., 2007) and that basal COX-2 expression in melanoma cells is associated with malignant transformation (Ku?
Positive_regulation (requires) of eIF-5A transcription factor associated with malignant neoplastic disease and skin cancer
10) Confidence 0.02 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0.28 Pain Relevance 0

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