INT41593

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Context Info
Confidence 0.05
First Reported 1981
Last Reported 1981
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.54
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prf1) endosome (Prf1) extracellular region (Prf1)
cytoplasmic membrane-bounded vesicle (Prf1) plasma membrane (Prf1) molecular_function (Prf1)
Anatomy Link Frequency
macrophages 4
Prf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 16 100.00 Very High Very High Very High
Inflammation 2 86.40 High High
Demyelination 4 85.36 High High
Neuritis 2 66.12 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 6 75.00 Quite High
Experimental Autoimmune Neuritis 2 66.12 Quite High
Syndrome 2 64.72 Quite High
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results similar to those with plasmin were obtained with conditioned media from macrophages and macrophage-like cell lines together with plasminogen activator, and the degradation of the PNS myelin proteins, Po and P1, under these conditions was inhibited by p-nitrophenylguanidinobenzoate, an inhibitor of plasmin and plasminogen activator.
Negative_regulation (inhibited) of Protein_catabolism (degradation) of P1 in macrophages associated with peripheral nervous system
1) Confidence 0.05 Published 1981 Journal J. Neurochem. Section Abstract Doc Link 6167674 Disease Relevance 0.27 Pain Relevance 0.50
Results similar to those with plasmin were obtained with conditioned media from macrophages and macrophage-like cell lines together with plasminogen activator, and the degradation of the PNS myelin proteins, Po and P1, under these conditions was inhibited by p-nitrophenylguanidinobenzoate, an inhibitor of plasmin and plasminogen activator.
Negative_regulation (inhibited) of in macrophage Protein_catabolism (degradation) of P1 in macrophages associated with peripheral nervous system
2) Confidence 0.02 Published 1981 Journal J. Neurochem. Section Abstract Doc Link 6167674 Disease Relevance 0.27 Pain Relevance 0.50

General Comments

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