INT416

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2010
Negated 71
Speculated 23
Reported most in Abstract
Documents 253
Total Number 279
Disease Relevance 31.48
Pain Relevance 125.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 45
pituitary 11
brain 5
blood 4
MPOA 4
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 746 100.00 Very High Very High Very High
Morphine 321 100.00 Very High Very High Very High
opiate 283 100.00 Very High Very High Very High
antagonist 249 100.00 Very High Very High Very High
Opioid 170 100.00 Very High Very High Very High
agonist 158 100.00 Very High Very High Very High
anesthesia 118 100.00 Very High Very High Very High
Endogenous opioid 100 100.00 Very High Very High Very High
withdrawal 53 100.00 Very High Very High Very High
opioid receptor 48 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 351 100.00 Very High Very High Very High
Urological Neuroanatomy 69 100.00 Very High Very High Very High
Galactorrhea 45 100.00 Very High Very High Very High
Hypoglycemia 30 100.00 Very High Very High Very High
Aids-related Complex 22 100.00 Very High Very High Very High
Nociception 33 99.84 Very High Very High Very High
Uremia 17 99.84 Very High Very High Very High
Depression 16 99.62 Very High Very High Very High
Pain 4 99.16 Very High Very High Very High
Diabetes Mellitus 47 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the administration of apomorphine (1.5 mg/kg), a dopamine receptor-stimulating agent, had no effect on the plasma LH levels.
Neg (no) Regulation (effect) of LH in plasma associated with dopamine receptor
1) Confidence 0.62 Published 1981 Journal Endocrinology Section Abstract Doc Link 6258902 Disease Relevance 0 Pain Relevance 0.23
Effects of different opiates on hypothalamic monoamine turnover and on plasma LH levels in pro-oestrous rats.
Regulation (Effects) of LH in plasma associated with narcan, opiate and monoamine
2) Confidence 0.62 Published 1989 Journal J. Neurol. Sci. Section Title Doc Link 2559164 Disease Relevance 0 Pain Relevance 1.36
Levorphanol (another mu-agonist) significantly decreased both NA and 5-HT concentrations and had no effect on circulating LH.
Neg (no) Regulation (effect) of LH associated with noradrenaline and agonist
3) Confidence 0.62 Published 1989 Journal J. Neurol. Sci. Section Abstract Doc Link 2559164 Disease Relevance 0 Pain Relevance 1.34
The results of these studies suggest that endogenous opioids exist in brain tissue which normally inhibit activity in the hypothalamic-pituitary-LH axis and participate in the androgen-dependent feedback control of LH elaboration by this axis.
Regulation (control) of LH in pituitary associated with endogenous opioid
4) Confidence 0.61 Published 1979 Journal Endocrinology Section Abstract Doc Link 374068 Disease Relevance 0 Pain Relevance 0.54
Dopaminergic and adrenergic effects on plasma LH levels in rats with hypothalamic islands.
Regulation (effects) of LH in plasma
5) Confidence 0.61 Published 1981 Journal Acta Endocrinol. Section Title Doc Link 7257697 Disease Relevance 0 Pain Relevance 0.04
In contrast, we were unable to demonstrate any enhancement of the effects of naloxone on serum LH levels by ketocyclazocine, cyclazocine or SKF 10,047, prototypic ligands for kappa and sigma binding sites in brain.
Regulation (effects) of LH in brain associated with narcan
6) Confidence 0.61 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6310081 Disease Relevance 0 Pain Relevance 1.45
The effect of naloxone or clonidine, on serum levels of luteinizing hormone (LH) was investigated in immature male and female rats.
Regulation (effect) of LH associated with narcan and clonidine
7) Confidence 0.61 Published 1982 Journal Life Sci. Section Abstract Doc Link 7162334 Disease Relevance 0 Pain Relevance 0.45
The mechanisms underlying the striking withdrawal-induced reversal of naloxone's effects on serum LH levels are presently unclear, but our data are consistent with the hypothesis that chronic morphine administration induces a fundamental change in the sensitivity of the endogenous opioid-mediated control of LH, which takes some time to revert to normal upon abrupt termination of opiate administration.
Regulation (control) of LH associated with endogenous opioid, narcan, opiate, withdrawal and morphine
8) Confidence 0.61 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3528453 Disease Relevance 0.06 Pain Relevance 0.96
[Effects of cutaneous mechanical stimulation on plasma corticosterone, luteinizing hormone (LH), and testosterone levels in anesthetized male rats].
Regulation (Effects) of LH in plasma associated with anesthesia
9) Confidence 0.61 Published 1994 Journal Hokkaido Igaku Zasshi Section Title Doc Link 8157248 Disease Relevance 0.13 Pain Relevance 0.10
The mechanisms underlying the striking withdrawal-induced reversal of naloxone's effects on serum LH levels are presently unclear, but our data are consistent with the hypothesis that chronic morphine administration induces a fundamental change in the sensitivity of the endogenous opioid-mediated control of LH, which takes some time to revert to normal upon abrupt termination of opiate administration.
Regulation (effects) of LH associated with endogenous opioid, narcan, opiate, withdrawal and morphine
10) Confidence 0.61 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3528453 Disease Relevance 0.06 Pain Relevance 1.04
Effects of cutaneous mechanical stimulation on plasma corticosterone, luteinizing hormone (LH), and testosterone levels were examined in young adult (13-22 weeks old) and aged (24-27 months old) male Wistar rats anesthetized with pentobarbital.
Spec (examined) Regulation (Effects) of LH in plasma
11) Confidence 0.61 Published 1994 Journal Hokkaido Igaku Zasshi Section Abstract Doc Link 8157248 Disease Relevance 0.07 Pain Relevance 0
However, innocuous mechanical stimulation of both hindlimbs by brushing for 10 min did not significantly change either plasma corticosterone, LH, or testosterone.
Neg (not) Regulation (change) of LH in plasma
12) Confidence 0.61 Published 1994 Journal Hokkaido Igaku Zasshi Section Abstract Doc Link 8157248 Disease Relevance 0.24 Pain Relevance 0
Plasma LH was not affected by stress, but 30 min after naloxone (1 or 10 mg/kg BW) injection, LH was elevated in both control and stressed rats above levels in vehicle-injected animals.
Neg (not) Regulation (affected) of LH in Plasma associated with stress, body weight and narcan
13) Confidence 0.61 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8202214 Disease Relevance 1.04 Pain Relevance 0.53
Surprisingly, we found that naloxone did not reverse the effects of morphine on serum LH levels in the prepubescent animal, although it fully reversed this effect in adults.
Neg (not) Regulation (effects) of LH associated with narcan and morphine
14) Confidence 0.61 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8380870 Disease Relevance 0.07 Pain Relevance 1.41
Hence, the effects of reproductive experience on opioid regulation of LH are less pronounced than those previously found for opioid regulation of prolactin and behaviour.
Regulation (regulation) of LH associated with opioid
15) Confidence 0.61 Published 1998 Journal J. Reprod. Fertil. Section Abstract Doc Link 10070356 Disease Relevance 0 Pain Relevance 0.73
The possible effects of prior reproductive experience on opioid control of LH during lactation were then investigated.
Regulation (control) of LH associated with opioid
16) Confidence 0.61 Published 1998 Journal J. Reprod. Fertil. Section Abstract Doc Link 10070356 Disease Relevance 0 Pain Relevance 0.79
The objective of the present study was to determine whether reproductive experience that produces shifts in opioid regulation of prolactin secretion and behavioural functions also alters opioid regulation of LH during the oestrous cycle or lactation.
Spec (whether) Regulation (regulation) of LH associated with opioid
17) Confidence 0.61 Published 1998 Journal J. Reprod. Fertil. Section Abstract Doc Link 10070356 Disease Relevance 0 Pain Relevance 0.43
Overall, these data indicate that while modest differences were found in naloxone-induced LH responses between multiparous and primiparous animals during lactation, reproductive experience did not significantly alter opioid regulation of LH during subsequent oestrous cycles at the naloxone doses examined.
Regulation (regulation) of LH associated with narcan and opioid
18) Confidence 0.61 Published 1998 Journal J. Reprod. Fertil. Section Abstract Doc Link 10070356 Disease Relevance 0 Pain Relevance 0.77
Lesions in the MPOA had no effect on plasma LH levels at 1 to 6 weeks when compared to controls.
Neg (no) Regulation (effect) of LH in MPOA associated with urological neuroanatomy
19) Confidence 0.61 Published 1982 Journal Brain Res. Bull. Section Abstract Doc Link 7093732 Disease Relevance 0.41 Pain Relevance 0.18
This study was designed to investigate the effect of anterolateral hypothalamic deafferentiation (ALHD) and medial preoptic area (MPOA) lesions on plasma LH levels in the long term ovariectomized rat.
Spec (investigate) Regulation (effect) of LH in MPOA associated with urological neuroanatomy
20) Confidence 0.61 Published 1982 Journal Brain Res. Bull. Section Abstract Doc Link 7093732 Disease Relevance 0.36 Pain Relevance 0.14

General Comments

Negative_regulation of Gene_expression of beta 4 nicotinic receptor subunits

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