INT41604

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.30
First Reported 1981
Last Reported 1982
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.32
Pain Relevance 5.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Sp1) nucleus (Sp1) intracellular (Sp1)
DNA binding (Sp1) transcription factor binding (Sp1) cytoplasm (Sp1)
Anatomy Link Frequency
spinal cord 4
Sp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 44 100.00 Very High Very High Very High
substance P 40 100.00 Very High Very High Very High
Spinal cord 13 100.00 Very High Very High Very High
Sciatic nerve 6 98.68 Very High Very High Very High
Pain 4 93.64 High High
Dorsal horn 5 87.76 High High
narcan 3 87.20 High High
withdrawal 12 85.36 High High
Somatostatin 2 75.00 Quite High
intrathecal 6 70.48 Quite High
Disease Link Frequency Relevance Heat
Pain 1 93.64 High High
Nociception 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin-evoked release of I-SP from rat spinal cord was reduced by 93% after neonatal treatment, but only by 69% 2 weeks after adult treatment.
Negative_regulation (reduced) of Localization (release) of I-SP in spinal cord associated with qutenza, spinal cord and substance p
1) Confidence 0.30 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6182473 Disease Relevance 0.07 Pain Relevance 1.36
Treatment of mice on day 2 caused a similar decrease of the I-SP content in spinal cord and of the capsaicin-evoked I-SP release (88%) as treatment on day 4 or 7 although behavioral changes were different.
Negative_regulation (decrease) of Localization (release) of I-SP in spinal cord associated with qutenza, spinal cord and substance p
2) Confidence 0.30 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6182473 Disease Relevance 0.07 Pain Relevance 1.42
After treatment of adult mice release of I-SP was reduced by 93%.
Negative_regulation (reduced) of Localization (release) of I-SP associated with substance p
3) Confidence 0.30 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6182473 Disease Relevance 0.07 Pain Relevance 1.45
The marked reduction of the release of I-SP after systemic capsaicin pretreatment may well represent one of the, or even the reason for the insensitivity of capsaicin pretreated rats towards chemogenic pain.
Negative_regulation (reduction) of Localization (release) of I-SP associated with pain, qutenza and substance p
4) Confidence 0.03 Published 1981 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6168921 Disease Relevance 0.09 Pain Relevance 1.64

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox