INT41621

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Context Info
Confidence 0.43
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.60
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren1) extracellular space (Ren1) extracellular region (Ren1)
intracellular (Ren1) response to stress (Ren1)
Ren1 (Mus musculus)
Pain Link Frequency Relevance Heat
beta blocker 2 97.64 Very High Very High Very High
Clonidine 1 91.68 High High
withdrawal 2 83.72 Quite High
antagonist 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 28 97.40 Very High Very High Very High
Hypertension 1 82.32 Quite High
Chronic Renal Failure 64 78.56 Quite High
Proteinuria 21 76.16 Quite High
Cv Unclassified Under Development 18 65.76 Quite High
Myocardial Infarction 2 45.76 Quite Low
Left Ventricular Hypertrophy 1 35.64 Quite Low
Renal Disease 23 5.00 Very Low Very Low Very Low
Hyperkalemia 8 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The beta-blockers with intrinsic sympathomimetic activity such as pindolol were found to increase renin activity when given alone, but blocked an increase in renin activity when given prior to isoproterenol.
Negative_regulation (blocked) of Positive_regulation (increase) of renin associated with beta blocker
1) Confidence 0.43 Published 1980 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6171684 Disease Relevance 0 Pain Relevance 0.14
Thus, aliskiren may contribute to end organ protection by reducing the deleterious actions of Ang II and the Ang II-independent effects of (pro)renin receptor activation.
Negative_regulation (reducing) of Positive_regulation (activation) of renin
2) Confidence 0.24 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.60 Pain Relevance 0.04

General Comments

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