INT41627

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Context Info
Confidence 0.65
First Reported 1982
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 33
Total Number 37
Disease Relevance 4.58
Pain Relevance 10.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nqo1) oxidoreductase activity (Nqo1) aging (Nqo1)
cytoplasm (Nqo1)
Anatomy Link Frequency
neuronal 5
neurons 5
brain 3
neck muscles 2
nerve 2
Nqo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 14 100.00 Very High Very High Very High
Somatostatin 9 99.80 Very High Very High Very High
amygdala 13 99.76 Very High Very High Very High
Versed 10 99.58 Very High Very High Very High
tetrodotoxin 3 99.56 Very High Very High Very High
qutenza 34 99.48 Very High Very High Very High
Spinal cord 23 99.04 Very High Very High Very High
parabrachial 4 98.68 Very High Very High Very High
dorsal root ganglion 1 98.48 Very High Very High Very High
Dorsal horn 8 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 15 98.00 Very High Very High Very High
Muscle Weakness 2 97.60 Very High Very High Very High
Nociception 9 97.24 Very High Very High Very High
Disease 10 96.76 Very High Very High Very High
Fatigue 4 95.28 Very High Very High Very High
Gliosis 4 94.16 High High
Cv Unclassified Under Development 93 87.84 High High
Injury 84 85.12 High High
Reperfusion Injury 12 81.20 Quite High
INFLAMMATION 10 79.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Investigation of c-fos expression and NADPH-diaphorase activity in the spine cord and brain in the development of the neck muscle weakness in rats].
Gene_expression (activity) of NADPH-diaphorase in spine associated with muscle weakness
1) Confidence 0.65 Published 2006 Journal Fiziol Zh Section Title Doc Link 17333617 Disease Relevance 0.26 Pain Relevance 0.15
The distribution of NADPH-diaphorase was studied in retrogradely labelled dorsal root ganglion cells innervating the knee joint of the cat.
Gene_expression (distribution) of NADPH-diaphorase in knee joint associated with ganglion cysts and dorsal root ganglion
2) Confidence 0.64 Published 1994 Journal Brain Res. Section Abstract Doc Link 7704613 Disease Relevance 0.18 Pain Relevance 0.09
We purified an NADPH-dependent coenzyme Q reductase (NADPH-CoQ reductase) in rat liver cytosol and compared its enzymatic properties with those of the other CoQ10 reductases such as NADPH: quinone acceptor oxidoreductase 1 (NQO1), lipoamide dehydrogenase, thioredoxine reductase and glutathione reductase.
Gene_expression (reductases) of NQO1 in liver
3) Confidence 0.63 Published 2008 Journal Biofactors Section Abstract Doc Link 19096101 Disease Relevance 0 Pain Relevance 0
Similar basic morphologies of the presumed interneurons and double staining of NADPH-diaphorase positive and somatostatin immunoreactive neurons suggest that the two neuropeptides and NADPH-diaphorase are extensively colocalized in the cultures, as in vivo.
Gene_expression (positive) of NADPH-diaphorase in neurons associated with neuropeptide and somatostatin
4) Confidence 0.62 Published 1995 Journal Exp Brain Res Section Abstract Doc Link 7615039 Disease Relevance 0.26 Pain Relevance 0.42
Expression of NADPH-diaphorase and colocalization with Fos in the brain neurons of the rat following visceral noxious stimulation.
Gene_expression (Expression) of diaphorase in brain associated with pain
5) Confidence 0.62 Published 1999 Journal Brain Res. Section Title Doc Link 10407110 Disease Relevance 0 Pain Relevance 0.26
The present study reveals an expression of NADPH-diaphorase in the rat brain samples administered by L-arginine.
Gene_expression (expression) of NADPH-diaphorase in brain
6) Confidence 0.60 Published 2010 Journal Brain Res. Section Abstract Doc Link 19931515 Disease Relevance 0.23 Pain Relevance 0.94
The NADPH-diaphorase and the acetylcholinesterase could be detected both in cell bodies, and in neuronal processes contacting groups of neighbouring neurones.
Gene_expression (detected) of NADPH-diaphorase in neuronal
7) Confidence 0.60 Published 1994 Journal Tissue Cell Section Abstract Doc Link 7886679 Disease Relevance 0 Pain Relevance 0
Considerable numbers of neurones were also found to express NADPH-diaphorase activity, while a smaller number of neurones were positive for acetylcholinesterase.
Gene_expression (express) of NADPH-diaphorase
8) Confidence 0.60 Published 1994 Journal Tissue Cell Section Abstract Doc Link 7886679 Disease Relevance 0 Pain Relevance 0
In monitoring the target genes of miR-21 in the expression array at 1, 3, 7, 14 d after reperfusion, with persistent expression throughout the experiment, we detected the same 4 persistently downregulated target genes (Nqo1, Pdpn, CXCL3, and Rad23b) with the prediction algorithms miRanda and RNAhybrid, but no target gene was revealed with PicTar, TargetScanS, and MirTarget2.


Gene_expression (detected) of Nqo1
9) Confidence 0.58 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2894749 Disease Relevance 0.36 Pain Relevance 0.10
In monitoring the target genes of miR-21 in the expression array at 1, 3, 7, 14 d after reperfusion, with persistent expression throughout the experiment, we detected the same 4 persistently downregulated target genes (Nqo1, Pdpn, CXCL3, and Rad23b) with the prediction algorithms miRanda and RNAhybrid, but no target gene was revealed with PicTar, TargetScanS, and MirTarget2.


Gene_expression (expression) of Nqo1
10) Confidence 0.58 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2894749 Disease Relevance 0.37 Pain Relevance 0.11
The expression of the Nqo1 gene is primarily regulated via antioxidant response element sequences in the promoter region.
Gene_expression (expression) of Nqo1
11) Confidence 0.58 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.87 Pain Relevance 0.04
The distribution of c-fos expression as a marker of neuronal activation and NADPH-diaphorase reactivity were examined in the cervical spinal cord, limbic structures and hypothalamus in anaesthetized rats after fatigue induced by intermittent high-rate (100 s(-1)) electrical stimulation of the dorsal neck muscles (mm. trapezius and splenius).
Gene_expression (expression) of NADPH-diaphorase in neck muscles associated with fatigue and spinal cord
12) Confidence 0.58 Published 2006 Journal Fiziol Zh Section Abstract Doc Link 17333617 Disease Relevance 0.23 Pain Relevance 0.11
About 6 to 9% of M-Enk immunoreactive neurons in the paraventricular, arcuate and ventromedial nuclei expressed NADPH-diaphorase activity.
Gene_expression (expressed) of NADPH-diaphorase in neurons
13) Confidence 0.51 Published 1994 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 7528149 Disease Relevance 0 Pain Relevance 0.61
2,3-Dimethoxy 1,4-naphthoquinone (DMNQ), which redox cycles via two-electron reduction, mediates reduction of the cell-impermeative tetrazolium dye WST-1 in kidney epithelial cells (MDCK), which express high levels of NQO1, but not in HL60 or CHO cells, which are NQO1 deficient.
Gene_expression (express) of NQO1 in MDCK
14) Confidence 0.46 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19932748 Disease Relevance 0 Pain Relevance 0.08
NADPH-diaphorase reactivity had the same neuronal distribution as NOS immunoreactivity and, in addition, NADPH-diaphorase reactivity was expressed in ductal epithelium.
Gene_expression (expressed) of NADPH-diaphorase in neuronal
15) Confidence 0.42 Published 1997 Journal Histochem. J. Section Abstract Doc Link 9413740 Disease Relevance 0.28 Pain Relevance 0.09
NADPH-diaphorase positive neurons and fibers identified by histochemistry were present in the myenteric plexus and along both circular and longitudinal muscle fibers indicating that nitric oxide could be synthetized by these neural structures.
Gene_expression (present) of NADPH-diaphorase in neurons
16) Confidence 0.30 Published 1993 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 8136734 Disease Relevance 0 Pain Relevance 0.10
In this study, we examined the effect of acute capsaicin injection on nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d, a histochemical index of nitric oxide, NO, synthase) and Fos expression in the rat pituitary gland.
Gene_expression (expression) of diaphorase in pituitary gland associated with qutenza
17) Confidence 0.25 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11090977 Disease Relevance 0 Pain Relevance 0.48
NADPH-diaphorase activity (NADPH-DA), a marker of neural nitric oxide synthase, was found in many postganglionic nerve cell bodies in the adult rat superior cervical ganglion (SCG) after colchicine treatment, postganglionic nerve trunk ligation or ganglion culture.
Gene_expression (found) of NADPH-diaphorase in nerve cell associated with ganglion cysts
18) Confidence 0.24 Published 1994 Journal Brain Res. Section Abstract Doc Link 7953706 Disease Relevance 0.41 Pain Relevance 0.23
In addition NADPH diaphorase positive neurons of the PPTg, and ChAT positive cells of the basal forebrain were counted using a square grid graticule.
Gene_expression (neurons) of NADPH diaphorase in forebrain
19) Confidence 0.22 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2257968 Disease Relevance 0.15 Pain Relevance 0
Expression and colocalization of NADPH-diaphorase and Fos in the subnuclei of the parabrachial nucleus in rats following visceral noxious stimulation.
Gene_expression (Expression) of diaphorase in parabrachial nucleus associated with pain and parabrachial
20) Confidence 0.21 Published 2006 Journal Brain Res. Section Title Doc Link 16919249 Disease Relevance 0 Pain Relevance 0.37

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