INT41635

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 1982
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.28
Pain Relevance 4.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg1) plasma membrane (Gabrg1)
Anatomy Link Frequency
neural 2
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 269 100.00 Very High Very High Very High
GABA receptor 18 100.00 Very High Very High Very High
Lasting pain 1 99.96 Very High Very High Very High
Pain score 1 98.82 Very High Very High Very High
GABAergic 26 98.54 Very High Very High Very High
antagonist 60 98.28 Very High Very High Very High
addiction 6 97.40 Very High Very High Very High
Antinociceptive 3 94.88 High High
Raphe 7 93.28 High High
carbamazepine 6 92.64 High High
Disease Link Frequency Relevance Heat
Pain 2 99.96 Very High Very High Very High
Ganglion Cysts 52 82.52 Quite High
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Myopia 2 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low
Refractive Errors 2 5.00 Very Low Very Low Very Low
Retina Disease 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Ocular Hypertension 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data establish that GABAergic regulation is a common mechanism across neural circadian clocks because blockade of GABA receptors in SCN explants also increases Per1::luc rhythmic amplitude [65], and application of GABA resets the phase of spike frequency rhythms in isolated SCN neurons [81].
Positive_regulation (increases) of Negative_regulation (blockade) of GABA in neural associated with gaba, gaba receptor and gabaergic
1) Confidence 0.45 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.08 Pain Relevance 0.63
These results indicate that blockade of both GABAA and GABAC receptors is necessary to attenuate GABA inhibition of retinal rhythms with, again, no dependence on GABAB receptors.
Positive_regulation (necessary) of Negative_regulation (blockade) of GABAA associated with addiction and gaba
2) Confidence 0.45 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.78
We attempted to estimate GABA turnover from the rate of disappearance of GABA after inhibition of glutamic acid decarboxylase by isoniazid and by the rate of accumulation of GABA after inhibition of GABA transaminase by gabaculine.
Positive_regulation (accumulation) of Negative_regulation (inhibition) of GABA associated with gaba
3) Confidence 0.16 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 6174697 Disease Relevance 0 Pain Relevance 1.46
It should be noted that bicuculline 0.75 mg/kg by itself increased pain score in the second phase of the formalin test, indicating that blockade of GABAA receptor subtype may induce chronic pain.
Spec (may) Positive_regulation (induce) of Negative_regulation (blockade) of GABAA receptor associated with pain score and lasting pain
4) Confidence 0.16 Published 2006 Journal Int. J. Neurosci. Section Abstract Doc Link 16861171 Disease Relevance 0.20 Pain Relevance 1.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox