INT41639

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 1981
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 10
Disease Relevance 4.52
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (A2m) extracellular region (A2m) enzyme binding (A2m)
Anatomy Link Frequency
Hepatocyte 1
liver 1
brain 1
A2m (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 2 99.96 Very High Very High Very High
Inflammation 28 99.62 Very High Very High Very High
Arthritis 6 98.96 Very High Very High Very High
cINOD 10 95.60 Very High Very High Very High
Hippocampus 24 90.88 High High
Paracetamol 4 90.84 High High
aspirin 1 76.96 Quite High
ischemia 32 74.28 Quite High
Inflammatory stimuli 1 42.56 Quite Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 33 99.78 Very High Very High Very High
Myocardial Infarction 152 99.16 Very High Very High Very High
Asphyxia 12 99.12 Very High Very High Very High
Experimental Arthritis 5 98.96 Very High Very High Very High
Sprains And Strains 5 97.24 Very High Very High Very High
Injury 9 97.16 Very High Very High Very High
Apoptosis 8 96.40 Very High Very High Very High
Disorder Of Lipid Metabolism 2 93.64 High High
Poisoning 2 91.36 High High
Pressure And Volume Under Development 4 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of alpha2-macroglobulin acute phase protein in rats by the injection of turpentine revealed strain and sex differences in the amounts of this protein detected in sera by rocket immunoelectrophoresis.
Positive_regulation (Induction) of alpha2-macroglobulin associated with sprains and strains
1) Confidence 0.46 Published 1981 Journal Agents Actions Section Abstract Doc Link 6175194 Disease Relevance 0.25 Pain Relevance 0.29
Similarly, administration of PGE1 (1 mg/kg) was found to increase serum alpha 2M levels in normal rats.
Positive_regulation (increase) of 2M
2) Confidence 0.32 Published 1984 Journal Biochem Med Section Abstract Doc Link 6202298 Disease Relevance 0.35 Pain Relevance 0.13
Induction of carrageenin inflammation in rats caused an elevation of alpha 2M to a maximum level (100%) at 1 day.
Positive_regulation (elevation) of 2M associated with inflammation
3) Confidence 0.32 Published 1984 Journal Biochem Med Section Abstract Doc Link 6202298 Disease Relevance 0.35 Pain Relevance 0.13
Hepatocyte injury suggested by elevated aminotransferase activity (ALT 10 times control value, AST 30 times control value), acute phase inflammatory response (serum alpha 2-macroglobulin increase) and reduced synthetic function (serum albumin decrease), was confirmed histologically and only zone 3 hepatocytes were necrotic.
Positive_regulation (increase) of serum alpha 2-macroglobulin in Hepatocyte associated with inflammatory response and injury
4) Confidence 0.31 Published 1993 Journal Life Sci. Section Abstract Doc Link 8464345 Disease Relevance 0.36 Pain Relevance 0.35
These results indicate that (a) primary prostaglandins, like PGE1, generated during inflammation may be responsible for the increase of alpha 2M in serum, and (b) PGE1 enhanced the synthesis of alpha 2M in liver and its secretion into the medium, so the anti-inflammatory drugs which decrease levels of PGs are likely to alter alpha 2M levels.
Positive_regulation (increase) of 2M in liver associated with inflammation and cinod
5) Confidence 0.22 Published 1984 Journal Biochem Med Section Abstract Doc Link 6202298 Disease Relevance 0.46 Pain Relevance 0.24
Moreover, we proved by qRT-PCR that major gene expression changes indeed occur due to the experimental treatment, since Mac-1 was found to be upregulated 10 to 20-fold in the asphyxia groups compared to the control group (Fig. 6).
Positive_regulation (upregulated) of Mac-1 associated with asphyxia
6) Confidence 0.14 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2430208 Disease Relevance 0.33 Pain Relevance 0
We found an about 10- to 20-fold upregulation of Mac-1 four days after the ACA insult which persisted during the later time points analyzed (Fig. 6).


Positive_regulation (upregulation) of Mac-1 associated with myocardial infarction
7) Confidence 0.14 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2430208 Disease Relevance 0.36 Pain Relevance 0
Mac-1, the microglia marker is clearly upregulated, mirroring activation/proliferation of these cells in the injured brain after ACA.
Positive_regulation (upregulated) of Mac-1 in brain associated with myocardial infarction
8) Confidence 0.14 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2430208 Disease Relevance 0.68 Pain Relevance 0.13
The microglial marker Mac-1, used as a target gene to validate the experimental model, was found to be upregulated about 10- to 20-fold after cardiac arrest.
Positive_regulation (upregulated) of Mac-1 associated with myocardial infarction
9) Confidence 0.12 Published 2008 Journal BMC Mol Biol Section Abstract Doc Link PMC2430208 Disease Relevance 0.60 Pain Relevance 0.12
The effect of adjuvant arthritis (AA) on the pattern of rat serum proteins includes the upregulation of haptoglobin, orosomucoid, alpha2-macroglobulin, serine protease inhibitor-3, thiostatin, alpha1-antitrypsin, C-reactive protein, and the downregulation of kallikrein-binding protein, alpha1-inhibitor III, apolipoprotein A-I, alpha2-HS-glycoprotein, albumin, apolipoprotein A-IV, transthyretin and transferrin.
Positive_regulation (upregulation) of alpha2-macroglobulin associated with experimental arthritis, disorder of lipid metabolism and arthritis
10) Confidence 0.04 Published 2000 Journal Electrophoresis Section Abstract Doc Link 10892728 Disease Relevance 0.78 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox