INT41689

Context Info Confidence 0.75 First Reported 1981 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 11 Total Number 12 Disease Relevance 6.61 Pain Relevance 0.28

cytosol (PHGDH) small molecule metabolic process (PHGDH) oxidoreductase activity (PHGDH) cellular nitrogen compound metabolic process (PHGDH)

Anatomy Link Frequency Th2 cells 1 PHGDH (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 2 91.12 aspirin 1 76.56 diclofenac 1 75.04 alcohol 16 60.04 Dismenorea 46 50.00 Sciatica 2 25.00 depression 4 5.00 Pain 3 5.00 withdrawal 2 5.00 Opioid 2 5.00

Disease Link Frequency Relevance Heat Nicotine Addiction 744 99.98 Visceral Leishmaniasis 94 99.98 Syndrome 7 96.84 Disease 19 93.64 INFLAMMATION 2 90.92 Reprotox - General 1 40 89.52 Obesity 11 54.96 Premenstrual Syndrome 67 50.00 Stress 8 47.20 Birth Weight 16 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We next sought to determine whether VL sera with low/borderline ELISA reactivity against rK39 could be detected with greater accuracy using rK28.

Gene_expression (detected) of sera associated with visceral leishmaniasis

1) Confidence 0.75 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.48 Pain Relevance 0

In this study, we present evidence demonstrating that the novel PGD(2) receptor chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is another functional target for indomethacin.

Gene_expression (expressed) of PGD in Th2 cells

2) Confidence 0.75 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11801628 Disease Relevance 0.17 Pain Relevance 0.25

No antibodies against the myelin basic protein (fragment 89-169) were detectable in the sera and CSF in any of the patients tested.

Gene_expression (detectable) of sera

3) Confidence 0.65 Published 1981 Journal J. Neurol. Section Abstract Doc Link 6181212 Disease Relevance 0.66 Pain Relevance 0

This required characterization of following key variables: a) ETS exposure status; b) ovulation status and the day of ovulation in each cycle; c) conception status in each ovulatory cycle; and d) modeling ETS exposure in relation to menstrual-day–specific urinary PdG and E1C levels.

Gene_expression (levels) of PdG associated with nicotine addiction

4) Confidence 0.44 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1278480 Disease Relevance 0.66 Pain Relevance 0

The effects of ETS exposure on daily urinary PdG and E1C levels in a ±10 day window around the day of ovulation were analyzed for conception and nonconception cycles, respectively.

Gene_expression (levels) of PdG associated with nicotine addiction

5) Confidence 0.44 Published 2005 Journal Environ Health Perspect Section Abstract Doc Link PMC1278480 Disease Relevance 0.93 Pain Relevance 0

Among conception cycles, there were no significant differences in E1C and PdG levels between ETS exposure and nonexposure.

Gene_expression (levels) of PdG associated with nicotine addiction

6) Confidence 0.44 Published 2005 Journal Environ Health Perspect Section Abstract Doc Link PMC1278480 Disease Relevance 0.89 Pain Relevance 0

Figure 2 illustrates daily mean E1C and PdG levels over the 20-day window of the menstrual cycles, stratified by conception versus nonconception cycles.

Gene_expression (levels) of PdG

7) Confidence 0.44 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1278480 Disease Relevance 0.68 Pain Relevance 0.03

We further used linear regression models to examine the associations between ETS exposure and daily log(PdG) and log(E1C) levels within the defined window.

Spec (examine) Gene_expression (exposure) of PdG associated with nicotine addiction

8) Confidence 0.39 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1278480 Disease Relevance 0.40 Pain Relevance 0

This algorithm had several limitations: a) The cut-point of a 60% decrease in E1C:PdG ratios in the preceding 2 days was derived from previously published data and was subject to the sensitivity of laboratory methods for detecting PdG and E1C; b) if there were missing data around ovulation, the algorithm may fail to detect the DLT; c) multiple DLTs may be detected in one cycle.

Gene_expression (detecting) of PdG

9) Confidence 0.39 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1278480 Disease Relevance 0.25 Pain Relevance 0

The central focus of our analysis was to examine the independent association between ETS exposure and urinary PdG and E1C profiles among eligible menstrual cycles.

Gene_expression (profiles) of PdG associated with nicotine addiction

10) Confidence 0.39 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1278480 Disease Relevance 0.42 Pain Relevance 0

There was no significant difference in urinary PdG levels in cycles having ETS exposure (?

Gene_expression (levels) of PdG associated with nicotine addiction

11) Confidence 0.39 Published 2005 Journal Environ Health Perspect Section Abstract Doc Link PMC1278480 Disease Relevance 1.07 Pain Relevance 0

E1 and PdG are expressed as nanograms and micrograms per mg Cr, respectively.

Gene_expression (expressed) of PdG

12) Confidence 0.34 Published 2007 Journal Biopsychosoc Med Section Body Doc Link PMC2253548 Disease Relevance 0 Pain Relevance 0

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