INT41719

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 1982
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 27
Total Number 32
Disease Relevance 19.43
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTOR) Golgi apparatus (MTOR) endoplasmic reticulum (MTOR)
cytoplasm (MTOR) cytosol (MTOR) signal transduction (MTOR)
Anatomy Link Frequency
blood 2
muscle 1
dorsal horn 1
tube 1
endothelial cells 1
MTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal dorsal horn 1 99.44 Very High Very High Very High
Nerve growth factor 3 96.96 Very High Very High Very High
Pain 17 95.52 Very High Very High Very High
Neuropeptide 2 94.48 High High
substance P 1 92.72 High High
Calcitonin gene-related peptide 1 91.04 High High
imagery 17 88.96 High High
antagonist 14 87.68 High High
cytokine 64 84.76 Quite High
Inflammation 63 84.36 Quite High
Disease Link Frequency Relevance Heat
Metabolic Syndrome 417 99.46 Very High Very High Very High
Disease 158 98.84 Very High Very High Very High
Renal Cell Carcinoma 116 98.84 Very High Very High Very High
Frailty 17 98.60 Very High Very High Very High
Obstructive Sleep Apnea 146 98.56 Very High Very High Very High
Thrombosis 56 98.28 Very High Very High Very High
Insulin Resistance 87 97.72 Very High Very High Very High
Stomach Cancer 2 97.52 Very High Very High Very High
Tuberous Sclerosis 4 97.48 Very High Very High Very High
Carcinoma 119 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that prolonged rapamycin treatment reduced the expression of total mTOR, which correlates with diminished levels of mTOR phosphorylation at Ser(2448) and Ser(2481).
Gene_expression (expression) of mTOR
1) Confidence 0.77 Published 2009 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19019920 Disease Relevance 0.39 Pain Relevance 0.07
Consequently, mTOR cellular expression can be used to evaluate the disease status and the risk of vascular thrombosis.
Gene_expression (expression) of mTOR associated with disease and thrombosis
2) Confidence 0.69 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.37 Pain Relevance 0.04
Our aim was therefore to investigate the expression of relevant proteins involved in IS pathway such as mTOR.
Spec (investigate) Gene_expression (expression) of mTOR
3) Confidence 0.69 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.75 Pain Relevance 0.03
Phosphorylation of the tyrosine residues 608 on IRS-1 after insulin stimulation is necessary for propagation of the signal with consequent active-mTOR expression.
Gene_expression (expression) of mTOR
4) Confidence 0.69 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.76 Pain Relevance 0.07
Total antioxidant activity (FRAP assay)
Gene_expression (assay) of FRAP
5) Confidence 0.65 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2566552 Disease Relevance 0.10 Pain Relevance 0
Total antioxidant activity (FRAP assay)
Gene_expression (assay) of FRAP
6) Confidence 0.65 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2556645 Disease Relevance 0.10 Pain Relevance 0
Transcutaneous iontophoresis of microtubule inhibitors (Vinblastin, Vincristin, Formyl-Leurosin) in rats induces depletion of fluoride-resistant acid phosphatase (FRAP) and transganglionic degenerative atrophy (trggl. deg. atr.) of the central terminals of primary nociceptive neurons, probably via blockade of axoplasmic transport in the peripheral sensory nerves.
Gene_expression (depletion) of FRAP in neurons associated with nociception and frailty
7) Confidence 0.65 Published 1982 Journal Acta Neurol. Scand. Section Abstract Doc Link 6183918 Disease Relevance 0.73 Pain Relevance 0.28
Blockade of retrograde transport of NGF results in transganglionic degenerative atrophy (TDA) in the segmentally related ipsilateral superficial spinal dorsal horn, which is characterized by depletion of the marker enzymes fluoride-resistant acid phosphatase (FRAP) and thiamine monophosphatase (TMP).
Gene_expression (depletion) of FRAP in dorsal horn associated with nerve growth factor, spinal dorsal horn and frailty
8) Confidence 0.65 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17319607 Disease Relevance 0.35 Pain Relevance 0.53
Their unique action is attributed to their effect directly on the tumor cells themselves, in part due to HIF downregulation, and on tumor endothelial cells by blocking proliferation and survival signals downstream of the VEGF receptor.23–25 One study has also shown that the benefits of mTOR inhibition may be greater in papillary renal carcinoma than in clear cell carcinoma; papillary subtype accounting for 10% to 15% of renal cell cancers.26 This is postulated to be due to HIF upregulation which is noted in patients with papillary renal cell carcinoma associated with fumarate–hydratase mutations.27
Neg (inhibition) Gene_expression (inhibition) of mTOR in endothelial cells associated with cancer, carcinoma and renal cell carcinoma
9) Confidence 0.63 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.90 Pain Relevance 0
The study also revealed that the benefit of mTOR inhibition might be greater in papillary renal carcinoma than in clear cell carcinoma.17
Neg (inhibition) Gene_expression (inhibition) of mTOR associated with carcinoma and renal cell carcinoma
10) Confidence 0.63 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.53 Pain Relevance 0
The mTOR pathway
Gene_expression (pathway) of mTOR
11) Confidence 0.63 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.90 Pain Relevance 0
We not only analyzed mTOR but also its downstream effectors p70S6K and 4EPB1 which stimulate anabolic pathway and other fundamental biochemical pathways such as the production of adhesion molecules, replace damaged cells and cell survival (including blood and endothelial cells with consequent regulation of blood coagulation).
Spec (analyzed) Gene_expression (analyzed) of mTOR in blood associated with adhesions
12) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 1.32 Pain Relevance 0.08
Current understanding of insulin signaling regulation considers IRS-1 to be a key protein in this cascade and mTOR activation.
Gene_expression (activation) of mTOR
13) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.64 Pain Relevance 0
We not only analyzed mTOR but also its downstream effectors p70S6K and 4EPB1 which stimulate anabolic pathway and other fundamental biochemical pathways such as the production of adhesion molecules, replace damaged cells and cell survival (including blood and endothelial cells with consequent regulation of blood coagulation).
Gene_expression (effectors) of mTOR in blood associated with adhesions
14) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 1.32 Pain Relevance 0.08
However, in the patient, we observed LOH deletion in AKT1, under-expression of AKT2, mTOR, elF4E, and over-expression of the negative regulators eIF4EBP1 and NKX3-1.
Gene_expression (expression) of mTOR
15) Confidence 0.56 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.81 Pain Relevance 0
mTOR exists in two complexes called mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), that differ in subunit composition and sensitivity to rapamycin.20 mTORC1 is highly sensitive to rapamycin whereas mTORC2 is relatively insensitive to rapamycin.21 HIF-1?
Gene_expression (exists) of mTOR
16) Confidence 0.55 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.65 Pain Relevance 0
Lymphocytes of MetS patients showed a reduced mTOR expression (the mammalian target of rapamycin) which is a fundamental molecule of IS.
Gene_expression (expression) of mTOR in Lymphocytes associated with metabolic syndrome
17) Confidence 0.53 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2940873 Disease Relevance 1.00 Pain Relevance 0
A reduced expression of mTOR may reflect an increased risk of vascular thrombosis.



Gene_expression (expression) of mTOR associated with thrombosis
18) Confidence 0.53 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2940873 Disease Relevance 0.76 Pain Relevance 0
Together, these findings suggest that signaling through mTOR may decline transiently during the early response of human muscle to immobilization and may contribute to decreased mitochondrial gene expression, possibly through interactions with PGC-1?
Gene_expression (signaling) of mTOR in muscle
19) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.23 Pain Relevance 0
However, in the patient, we observed LOH deletion in AKT1, under-expression of AKT2, mTOR, elF4E, and over-expression of the negative regulators eIF4EBP1 and NKX3-1.
Gene_expression (expression) of mTOR
20) Confidence 0.43 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.81 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox