INT41720

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Context Info
Confidence 0.49
First Reported 1982
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.54
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTOR) Golgi apparatus (MTOR) endoplasmic reticulum (MTOR)
cytoplasm (MTOR) cytosol (MTOR) signal transduction (MTOR)
Anatomy Link Frequency
neurons 2
MTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 75.00 Quite High
Intractable pain 1 67.44 Quite High
Trigeminal neuralgia 1 61.12 Quite High
diabetic neuropathy 1 58.24 Quite High
nociceptor 1 25.00 Low Low
positron emission tomography 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 2 98.60 Very High Very High Very High
Hyperplasia 1 96.52 Very High Very High Very High
Nociception 3 96.08 Very High Very High Very High
Apoptosis 2 94.28 High High
Cancer 105 83.08 Quite High
Pain 2 75.00 Quite High
Intractable Pain 1 67.44 Quite High
Headache 1 61.12 Quite High
Diabetic Neuropathy 1 58.24 Quite High
Adenocarcinoma 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcutaneous iontophoresis of microtubule inhibitors (Vinblastin, Vincristin, Formyl-Leurosin) in rats induces depletion of fluoride-resistant acid phosphatase (FRAP) and transganglionic degenerative atrophy (trggl. deg. atr.) of the central terminals of primary nociceptive neurons, probably via blockade of axoplasmic transport in the peripheral sensory nerves.
Spec (probably) Positive_regulation (induces) of Gene_expression (depletion) of FRAP in neurons associated with nociception and frailty
1) Confidence 0.49 Published 1982 Journal Acta Neurol. Scand. Section Abstract Doc Link 6183918 Disease Relevance 0.73 Pain Relevance 0.28
However, in the patient, we observed LOH deletion in AKT1, under-expression of AKT2, mTOR, elF4E, and over-expression of the negative regulators eIF4EBP1 and NKX3-1.
Positive_regulation (over) of Gene_expression (expression) of mTOR
2) Confidence 0.34 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.81 Pain Relevance 0
No significant difference was observed between any treatment groups for mRNA expression for PKB, mTOR, p70S6k, GSK-3?
Positive_regulation (groups) of Gene_expression (expression) of mTOR
3) Confidence 0.23 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0

General Comments

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