INT41728

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Context Info
Confidence 0.75
First Reported 1982
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 65
Total Number 65
Disease Relevance 42.19
Pain Relevance 12.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CHAT) mitochondrion (CHAT) nucleus (CHAT)
transferase activity, transferring acyl groups (CHAT) cytoplasm (CHAT)
Anatomy Link Frequency
neurons 6
lymphocytes 5
macrophages 4
smooth muscle cells 4
neutrophils 4
CHAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 91 100.00 Very High Very High Very High
substance P 4 100.00 Very High Very High Very High
Inflammatory stimuli 1 99.68 Very High Very High Very High
Spinal cord 313 99.44 Very High Very High Very High
Hippocampus 16 99.12 Very High Very High Very High
Enkephalin 75 98.96 Very High Very High Very High
Neuropeptide 14 98.76 Very High Very High Very High
Pain 65 98.72 Very High Very High Very High
Fibrositis 77 97.84 Very High Very High Very High
Inflammation 1142 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1324 99.52 Very High Very High Very High
Tendinopathy 26 99.32 Very High Very High Very High
Injury 210 99.02 Very High Very High Very High
Neuroblastoma 6 99.00 Very High Very High Very High
Motor Neuron Diseases 12 98.48 Very High Very High Very High
Disease 504 98.44 Very High Very High Very High
Fibromyalgia 77 97.84 Very High Very High Very High
Pain 59 97.66 Very High Very High Very High
Generalized Anxiety Disorder 14 97.48 Very High Very High Very High
Cold Sores 10 97.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously demonstrated this cell death can be prevented by HSV-mediated transfer of the gene coding for the antiapoptotic peptide Bcl-2 7 days prior to injury, but that expression of Bcl-2 does not preserve ChAT expression in the lesioned cells.
Gene_expression (expression) of ChAT associated with cold sores, injury and death
1) Confidence 0.75 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 11852979 Disease Relevance 0.96 Pain Relevance 0.03
Neither the Bcl-2-expressing vector nor the GDNF-expressing vector delivered alone protected choline acetyltransferase (ChAT) expression in lesioned neurons.
Gene_expression (expression) of ChAT in neurons
2) Confidence 0.75 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 11852979 Disease Relevance 0.58 Pain Relevance 0.04
We have studied pain-free normal Achilles tendons and chronically painful Achilles tendinosis tendons with regard to immunohistochemical expression patterns of the M(2) muscarinic acetylcholine receptor (M(2)R), choline acetyltransferase (ChAT), and vesicular acetylcholine transporter (VAChT).
Gene_expression (expression) of choline acetyltransferase in tendons associated with pain and tendinopathy
3) Confidence 0.75 Published 2008 Journal Cell Tissue Res. Section Abstract Doc Link 17999088 Disease Relevance 0.53 Pain Relevance 0.20
We have studied pain-free normal Achilles tendons and chronically painful Achilles tendinosis tendons with regard to immunohistochemical expression patterns of the M(2) muscarinic acetylcholine receptor (M(2)R), choline acetyltransferase (ChAT), and vesicular acetylcholine transporter (VAChT).
Gene_expression (expression) of ChAT in tendons associated with pain and tendinopathy
4) Confidence 0.75 Published 2008 Journal Cell Tissue Res. Section Abstract Doc Link 17999088 Disease Relevance 0.53 Pain Relevance 0.20
As ChAT and VAChT immunoreactions were detected in tenocytes of tendinosis tendons, these cells might be a source of local acetylcholine (Ach) production.
Gene_expression (detected) of ChAT in tendons associated with tendinopathy
5) Confidence 0.71 Published 2006 Journal Microsc. Res. Tech. Section Abstract Doc Link 16830327 Disease Relevance 0.67 Pain Relevance 0.25
A1 hybrid neurons also express messages for choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), and glutamic acid decarboxylase (GAD), indicating that they could differentiate into various subsets of neuronal types.
Gene_expression (express) of ChAT in neurons associated with generalized anxiety disorder
6) Confidence 0.68 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12460557 Disease Relevance 0.47 Pain Relevance 0.17
Choline acetyltransferase and substance P-like immuno-reactivity in the human spinal cord: changes in amyotrophic lateral sclerosis.
Gene_expression (immuno-reactivity) of Choline acetyltransferase in spinal cord associated with motor neuron diseases, spinal cord and substance p
7) Confidence 0.67 Published 1982 Journal Brain Res. Section Title Doc Link 6184125 Disease Relevance 0.39 Pain Relevance 0.42
Results: Immunoreactivities of all the antigens were present within both the lateral and medial efferent systems of the cochlea, whereas only ChAT, GABA, and CGRP were detected in efferent pathways of the vestibular end organs.


Gene_expression (detected) of ChAT in medial
8) Confidence 0.62 Published 2007 Journal Acta Otolaryngol. Section Body Doc Link 17364323 Disease Relevance 0 Pain Relevance 0
In the ileum, all CB1-R-immunoreactive neurons coexpressed immunoreactivity to the cholinergic marker, choline acetyltransferase (ChAT).
Gene_expression (coexpressed) of ChAT in ileum
9) Confidence 0.59 Published 2000 Journal Cell Tissue Res. Section Abstract Doc Link 11079717 Disease Relevance 0.07 Pain Relevance 0.15
In the ileum, all CB1-R-immunoreactive neurons coexpressed immunoreactivity to the cholinergic marker, choline acetyltransferase (ChAT).
Gene_expression (coexpressed) of choline acetyltransferase in ileum
10) Confidence 0.59 Published 2000 Journal Cell Tissue Res. Section Abstract Doc Link 11079717 Disease Relevance 0.07 Pain Relevance 0.15
A1 hybrid neurons also express messages for choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), and glutamic acid decarboxylase (GAD), indicating that they could differentiate into various subsets of neuronal types.
Gene_expression (express) of choline acetyltransferase in neurons associated with generalized anxiety disorder
11) Confidence 0.53 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12460557 Disease Relevance 0.47 Pain Relevance 0.17
In the distal colon, CB1-R-immunoreactive neurons also expressed immunoreactivity to ChAT, albeit less frequently than in ileum.
Gene_expression (expressed) of ChAT in ileum
12) Confidence 0.51 Published 2000 Journal Cell Tissue Res. Section Abstract Doc Link 11079717 Disease Relevance 0.06 Pain Relevance 0.20
Although the position of the ChAT-ir cell body does not indicate unequivocally where the ACh is released, the location of cholinergic interneurons within the matrix and the striosomes, as well as in the borders between these compartments, leads to assume that ACh release may happen in both the matrix and the striosomes.
Gene_expression (position) of ChAT in interneurons
13) Confidence 0.40 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137841 Disease Relevance 0 Pain Relevance 0.07
In order to analyze the distribution of the ChAT-ir neurons with respect to the matrix/striosome compartments, some sections were chosen at each anteroposterior level of the CN and Put and processed for ChAT (as described above) and enkephalin (ENK).
Gene_expression (processed) of ChAT in neurons associated with enkephalin
14) Confidence 0.40 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137841 Disease Relevance 0 Pain Relevance 0.43
Immunocytochemical techniques was used to compare the proportion of neurons expressing various neurotransmitters (tyrosine hydroxylase, choline acetyltransferase and gamma-aminobutyric acid), neuropeptides (Leu-enkephalin and substance P) and neural cell adhesion molecules (NCAM) in the hippocampus, frontal (area 10) and occipital (area 17) cortices of neurologically normal elderly humans to that of age-matched Alzheimer disease (AD) patients.
Gene_expression (expressing) of choline acetyltransferase in neural associated with neurotransmitter, alzheimer's dementia, neuropeptide, hippocampus, enkephalin, adhesions and substance p
15) Confidence 0.24 Published 1999 Journal Exp. Gerontol. Section Abstract Doc Link 10197733 Disease Relevance 0.54 Pain Relevance 0.37
4.4% of cells expressed the MN marker ChAT (Fig. 1h), while Olig 1/2 and HB9 expression decreased significantly (p<0.001; 2+/?
Gene_expression (expressed) of ChAT
16) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0 Pain Relevance 0
Similar to the day 21 immunocytochemical profile, less than 1% of cells expressed the astrocyte marker GFAP and no cells expressed the mature MN marker ChAT.
Neg (no) Gene_expression (expressed) of ChAT in astrocyte
17) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0 Pain Relevance 0
3.6% of cells expressed the MN marker HB9, and no cells expressed the mature MN marker ChAT.
Gene_expression (expressed) of ChAT
18) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.06 Pain Relevance 0
-bungarotoxin, synaptophysin and ChAT staining was significantly (p<0.001) increased over myotube cultures that lacked innervation.
Gene_expression (staining) of ChAT in myotube
19) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.07 Pain Relevance 0.11
-bungarotoxin, synaptophysin and ChAT staining could be detected in this system when no hMNPs were seeded.


Neg (no) Gene_expression (detected) of ChAT
20) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.06 Pain Relevance 0.09

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