INT41742

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Context Info
Confidence 0.43
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.78
Pain Relevance 3.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
blood 2
spinal cord 2
pituitary 2
dorsal root ganglion 2
glands 2
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 32 100.00 Very High Very High Very High
substance P 10 100.00 Very High Very High Very High
Spinal cord 2 100.00 Very High Very High Very High
dorsal root ganglion 3 99.68 Very High Very High Very High
qutenza 14 99.56 Very High Very High Very High
nociceptor 2 99.44 Very High Very High Very High
dorsal rhizotomy 1 97.32 Very High Very High Very High
Opioid 1 95.76 Very High Very High Very High
Calcitonin gene-related peptide 15 95.56 Very High Very High Very High
unmyelinated 4 92.52 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 99.20 Very High Very High Very High
Nociception 5 98.08 Very High Very High Very High
Stress 1 90.32 High High
Pressure And Volume Under Development 1 89.92 High High
INFLAMMATION 1 33.92 Quite Low
Dyspepsia 2 25.52 Quite Low
Ulcers 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 2 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The depletions of spinal cord substance P (55%) and somatostatin (20%) produced by neonatal capsaicin treatment were similar to those produced by dorsal rhizotomy.
Negative_regulation (depletions) of Gene_expression (produced) of somatostatin in spinal cord associated with dorsal rhizotomy, qutenza, somatostatin, substance p and spinal cord
1) Confidence 0.43 Published 1983 Journal J. Neurosci. Section Abstract Doc Link 6185658 Disease Relevance 0 Pain Relevance 1.23
These results suggest that adrenal steroid hormones may reduce the synthesis of both substance P and somatostatin in the dorsal root ganglion cells.
Spec (may) Negative_regulation (reduce) of Gene_expression (synthesis) of somatostatin in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, somatostatin and substance p
2) Confidence 0.42 Published 1994 Journal Brain Res. Section Abstract Doc Link 7516260 Disease Relevance 0.43 Pain Relevance 0.72
Intravenous injection of the putative mediator somatostatin (10 microg/kg) or its analogues RC-160 and TT-232, but not octreotide inhibited the cardiorespiratory and blood pressure responses evoked by topical cutaneous application of mustard oil or capsaicin instillation into the eye.
Negative_regulation (inhibited) of Gene_expression (injection) of somatostatin in blood associated with qutenza and somatostatin
3) Confidence 0.41 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10653024 Disease Relevance 0.35 Pain Relevance 0.65
The mechanisms involved in such effects were evaluated by measuring pituitary GH mRNA levels and hypothalamic levels of GH-releasing hormone (GHRH) and somatostatin (SRIF) mRNAs.
Negative_regulation (measuring) of Gene_expression (levels) of somatostatin in pituitary associated with somatostatin
4) Confidence 0.16 Published 1996 Journal J. Endocrinol. Section Abstract Doc Link 8958779 Disease Relevance 0 Pain Relevance 0.32
In rat studies, antral D cells were identified as acid sensitive because of decreased somatostatin production measured after treatment with proton-pump inhibitors, whereas corpus D cells, likely comparable to D cells in the gastric glands of the fundus, are CGRP sensitive and therefore under the influence of the gastric sensory afferent nerves rather than direct luminal content [16].
Negative_regulation (decreased) of Gene_expression (production) of somatostatin in glands associated with somatostatin and calcitonin gene-related peptide
5) Confidence 0.10 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0 Pain Relevance 0.36

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