INT41775

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Context Info
Confidence 0.71
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.46
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NEUROG1) DNA binding (NEUROG1)
Anatomy Link Frequency
AKA 5
NEUROG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 270 99.20 Very High Very High Very High
spinal inflammation 5 97.32 Very High Very High Very High
Inflammation 21 63.52 Quite High
COX2 1 56.96 Quite High
visual analogue scale 6 56.64 Quite High
Pain 7 55.60 Quite High
Arthritis 12 41.52 Quite Low
methotrexate 4 38.72 Quite Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Sclerosis 8 99.28 Very High Very High Very High
Rheumatoid Arthritis 270 99.20 Very High Very High Very High
Cancer 33 99.04 Very High Very High Very High
Low Back Pain 6 97.32 Very High Very High Very High
Colorectal Cancer 50 95.92 Very High Very High Very High
Disease 120 88.72 High High
Arthropathy 1 64.08 Quite High
INFLAMMATION 19 63.52 Quite High
Aging 1 60.20 Quite High
Pain 7 55.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, AKA were present in only 7 of 82 (9.5%) patients with other types of rheumatic disorders and in 2 of 47 (4.2%) healthy subjects.
Gene_expression (present) of AKA in AKA
1) Confidence 0.71 Published 1983 Journal Arthritis Rheum. Section Abstract Doc Link 6188470 Disease Relevance 0.71 Pain Relevance 0.35
In contrast, AKA were present in only 7 of 82 (9.5%) patients with other types of rheumatic disorders and in 2 of 47 (4.2%) healthy subjects.
Gene_expression (present) of AKA in AKA
2) Confidence 0.71 Published 2008 Journal Arthritis Rheum. Section Abstract Doc Link 18240220 Disease Relevance 0.71 Pain Relevance 0.35
AKA were not specific for RA, however, because in the former group, AKA were present in 4 of 20 (20%) systemic sclerosis patients and in 3 of 12 (25%) ankylosing spondylitis patients.
Gene_expression (present) of AKA in AKA associated with spinal inflammation, rheumatoid arthritis and systemic sclerosis
3) Confidence 0.48 Published 1983 Journal Arthritis Rheum. Section Abstract Doc Link 6188470 Disease Relevance 0.78 Pain Relevance 0.39
AKA were not specific for RA, however, because in the former group, AKA were present in 4 of 20 (20%) systemic sclerosis patients and in 3 of 12 (25%) ankylosing spondylitis patients.
Gene_expression (present) of AKA in AKA associated with spinal inflammation, rheumatoid arthritis and systemic sclerosis
4) Confidence 0.48 Published 2008 Journal Arthritis Rheum. Section Abstract Doc Link 18240220 Disease Relevance 0.78 Pain Relevance 0.39
They found that they could reliably identify tumours with the CIMP+ phenotype using a five gene set consisting of CACNA1G, IGF2, NEUROG1, RUNX3 and SOCS1, known collectively as the “CIMP Panel”
Gene_expression (consisting) of NEUROG1 associated with cancer
5) Confidence 0.43 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.74 Pain Relevance 0.03
CRP, RF and AKA were detected in 34 (56.7%), 43 (71.7%) and 31 (52%) of patients respectively.
Gene_expression (detected) of AKA
6) Confidence 0.08 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2577639 Disease Relevance 0 Pain Relevance 0
AKA was detected by kit supplied by IMMECO Diagnostic, Lot No. 2120-8, based on indirect immunofluorescence antibodies on rat esophagus substrate.


Gene_expression (detected) of AKA in esophagus
7) Confidence 0.05 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2577639 Disease Relevance 0.16 Pain Relevance 0.08
AKA can be detected by indirect immunofluorescence in 36–59% of RA sera with a specificity of 88–99% (reviewed in [42]).
Gene_expression (detected) of AKA associated with rheumatoid arthritis
8) Confidence 0.05 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128920 Disease Relevance 0.31 Pain Relevance 0.15
Due to practical inconvenience, APF was never introduced into clinical routine, whereas detection of AKA by indirect immunofluorescence was among the main laboratory tests used before anti-CCP enzyme-linked immunosorbent assay (ELISA) kits became commercially available.
Gene_expression (detection) of AKA
9) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779400 Disease Relevance 0.71 Pain Relevance 0.24
In this study, anti-CCP antibodies, CRP, RF and AKA were detected in 83.3%, 56.7%, 71.7% and 52% of patients respectively.
Gene_expression (detected) of AKA
10) Confidence 0.02 Published 2008 Journal Int Arch Med Section Abstract Doc Link PMC2577639 Disease Relevance 0.57 Pain Relevance 0.16

General Comments

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