INT41791

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Context Info
Confidence 0.49
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 5.69
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (NTS) extracellular region (NTS)
Anatomy Link Frequency
lung 2
visceral 1
liver 1
medulla 1
cleavage 1
NTS (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 8 100.00 Very High Very High Very High
Cholecystokinin 3 99.96 Very High Very High Very High
medulla 21 99.92 Very High Very High Very High
Serotonin 4 99.92 Very High Very High Very High
Central nervous system 15 99.36 Very High Very High Very High
substance P 25 99.04 Very High Very High Very High
Somatostatin 3 99.00 Very High Very High Very High
vagus nerve 4 98.64 Very High Very High Very High
c fibre 8 97.92 Very High Very High Very High
trigger zone 5 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Vomiting 125 99.54 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 93 99.48 Very High Very High Very High
Nicotine Addiction 19 98.88 Very High Very High Very High
Fatty Liver 28 98.08 Very High Very High Very High
Disease 36 97.84 Very High Very High Very High
Sleep Disorders 6 97.44 Very High Very High Very High
Sudden Infant Death Syndrome 6 92.68 High High
Cirrhosis 5 88.96 High High
Injury 9 88.08 High High
Fibrosis 22 82.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This species, relative to dog and humans, proved to be insensitive to a variety of pharmacologic agents including angiotensin II, gastrin, histamine, Leu-enkephalin, neurotensin, serotonin, and vasopressin.
Positive_regulation (insensitive) of neurotensin associated with enkephalin and serotonin
1) Confidence 0.49 Published 1993 Journal Brain Res. Bull. Section Abstract Doc Link 8495372 Disease Relevance 0.61 Pain Relevance 0.37
In the present study, we demonstrate that in Chinese hamster ovary (CHO) cells expressing the rat NTS2 receptor, neurotensin (NT), levocabastine, neuromedin N, and the high-affinity NT receptor antagonist SR48692 [2-[[1-(-7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid] all bind to and activate the NTS2 receptor.
Positive_regulation (activate) of NTS2 in CHO associated with antagonist
2) Confidence 0.41 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361549 Disease Relevance 0 Pain Relevance 0.28
Thus, an upregulation of the substance P system at NTS synapses could contribute to the increased NTS excitability and enhanced reflex responses to lung C-fiber stimulation, providing a potential mechanism to help explain the association of ETS exposure with respiratory symptoms and SIDS.



Positive_regulation (increased) of NTS in lung associated with c fibre, nicotine addiction, sudden infant death syndrome and substance p
3) Confidence 0.35 Published 2001 Journal Environ Health Perspect Section Abstract Doc Link PMC1240584 Disease Relevance 0.71 Pain Relevance 0.66
It appeared that, besides a major production of neurotensin(1-10), an additional formation of neurotensin(1-8) was observed with the pig enzyme, suggesting a cleavage of neurotensin not only at the Pro10-Tyr11 bond but also at the Arg8-Arg9 peptidyl bond.
Positive_regulation (cleavage) of neurotensin in cleavage
4) Confidence 0.32 Published 1996 Journal Brain Res. Section Abstract Doc Link 8869556 Disease Relevance 0 Pain Relevance 0.20
Such findings suggest that a larger bolus moving across more receptive fields excites more sensory fibers which synapse in the NTS and enhance the NTS drive of the motoneurons.
Positive_regulation (enhance) of NTS in motoneurons
5) Confidence 0.32 Published 2010 Journal Dysphagia Section Body Doc Link PMC2992653 Disease Relevance 0 Pain Relevance 0.04
Human endopeptidase 3.4.24.16 cleaved neurotensin at a unique site at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13).
Positive_regulation (cleaved) of neurotensin
6) Confidence 0.28 Published 1996 Journal Brain Res. Section Abstract Doc Link 8869556 Disease Relevance 0 Pain Relevance 0.18
Altogether, our results indicate that porcine endopeptidase 3.4.24.16 cleaves neurotensin at a unique site, leading to the formation of neurotensin(1-10) and that the production of neurotensin(1-8) is due to contaminating endopeptidase 3.4.24.15.
Positive_regulation (cleaves) of neurotensin
7) Confidence 0.28 Published 1996 Journal Brain Res. Section Abstract Doc Link 8869556 Disease Relevance 0 Pain Relevance 0.05
Several neuropeptides should be involved in Alzheimer's disease: substance P, endorphins, vasopressin, ACTH, somatostatin, vasoactive intestinal peptide, cholecystokinin, neurotensin, delta sleep-inducing peptide.
Positive_regulation (sleep-inducing) of neurotensin associated with somatostatin, neuropeptide, disease, cholecystokinin and substance p
8) Confidence 0.27 Published 1983 Journal Clin. Neuropathol. Section Abstract Doc Link 6189657 Disease Relevance 0.27 Pain Relevance 0.73
Exposing young guinea pigs to sidestream smoke, the surrogate for ETS, for 5 weeks during the equivalent of human childhood, increased the excitability of afferent lung C fibers and NTS neurons in the CNS reflex pathway and prolonged the expiratory apnea.
Positive_regulation (increased) of NTS in lung associated with nicotine addiction, central nervous system and sleep disorders
9) Confidence 0.25 Published 2001 Journal Environ Health Perspect Section Abstract Doc Link PMC1240584 Disease Relevance 1.03 Pain Relevance 0.59
Some of these fibres loop dorsomedially in the caudal ventrolateral medulla to innervate the NTS, and dorsal motor nucleus of the vagus nerve (X).
Positive_regulation (innervate) of NTS in medulla associated with medulla and vagus nerve
10) Confidence 0.15 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1629015 Disease Relevance 0.13 Pain Relevance 0.40
Another acceptation is that CINV results from directly activation of the NTS by visceral afferent neurons and/or by inputs from the CTZ.
Positive_regulation (activation) of NTS in visceral associated with trigger zone and vomiting
11) Confidence 0.07 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697542 Disease Relevance 1.33 Pain Relevance 0.43
NT AUROCs for the diagnosis of NASH or borderline NASH in NAFLD were unchanged in patients with ALT values lower than 50 IU/L (Table 6 and Table 7); therefore NT could be used to diagnose NASH even in patients that are not eligible for liver biopsy.
Positive_regulation (used) of NT in liver associated with fatty liver and nash(non-alcoholic steatohepatitis)
12) Confidence 0.05 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.61 Pain Relevance 0.21

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