INT41816

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.20
Pain Relevance 4.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
spinal cord 4
sensory nerve 2
Tac1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 98 100.00 Very High Very High Very High
substance P 45 100.00 Very High Very High Very High
Pain 33 100.00 Very High Very High Very High
calcitonin gene related peptide 14 100.00 Very High Very High Very High
Morphine 8 99.98 Very High Very High Very High
nociceptor 6 99.82 Very High Very High Very High
narcan 3 99.82 Very High Very High Very High
Spinal cord 8 99.76 Very High Very High Very High
orphanin 3 98.54 Very High Very High Very High
Antinociceptive 5 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 22 91.84 High High
INFLAMMATION 21 90.96 High High
Hyperalgesia 8 89.52 High High
Hemorrhage 2 84.80 Quite High
Increased Venous Pressure Under Development 6 84.16 Quite High
Ganglion Cysts 2 77.68 Quite High
Pain 39 70.04 Quite High
Abnormal Reflex 3 53.80 Quite High
Overactive Bladder 6 33.76 Quite Low
Interstitial Cystitis 1 28.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine inhibits substance P release from peripheral sensory nerve endings.
Negative_regulation (inhibits) of Localization (release) of substance P in sensory nerve associated with substance p and morphine
1) Confidence 0.35 Published 1983 Journal Acta Physiol. Scand. Section Title Doc Link 6192685 Disease Relevance 0 Pain Relevance 1.17
In the spinal cord denervation supersensitivity to 5-HT may depend on reduced release of substance P (SP).
Negative_regulation (reduced) of Localization (release) of substance P in spinal cord associated with substance p and spinal cord
2) Confidence 0.35 Published 1993 Journal Cephalalgia Section Abstract Doc Link 7684323 Disease Relevance 0.32 Pain Relevance 0.33
Inhibition of substance P release from spinal cord tissue after pretreatment with capsaicin does not mediate the antinociceptive effect of capsaicin in adult mice.
Negative_regulation (Inhibition) of Localization (release) of substance P in spinal cord associated with qutenza, antinociceptive, spinal cord and substance p
3) Confidence 0.28 Published 1997 Journal Pain Section Title Doc Link 9231870 Disease Relevance 0.24 Pain Relevance 2.25
Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand for the N/OFQ peptide receptor (NOP), inhibits tachykinin release in the airway of several animal models.
Negative_regulation (inhibits) of Localization (release) of tachykinin associated with orphanin
4) Confidence 0.17 Published 2010 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 19448152 Disease Relevance 0 Pain Relevance 0.32
This effect is TRPV1 specific as it was inhibited by capsazepine and suggested to occur as a result of CGRP and tachykinin release upon TRPV1 activation [86].
Negative_regulation (result) of Localization (release) of tachykinin associated with calcitonin gene related peptide
5) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.64 Pain Relevance 0.58

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox