INT41820

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Context Info
Confidence 0.49
First Reported 1982
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 0.46
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TRIM13) endoplasmic reticulum (TRIM13) intracellular (TRIM13)
ligase activity (TRIM13) cytoplasm (TRIM13) signal transducer activity (TRIM13)
Anatomy Link Frequency
NG108-15 1
respiratory 1
TRIM13 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 15 100.00 Very High Very High Very High
agonist 3 100.00 Very High Very High Very High
opiate 3 99.68 Very High Very High Very High
opioid receptor 1 99.28 Very High Very High Very High
Endogenous opioid 1 94.72 High High
mu opioid receptor 1 85.28 High High
Opioid 1 78.56 Quite High
medulla 1 77.36 Quite High
adenocard 2 64.36 Quite High
Disease Link Frequency Relevance Heat
Hypotension 1 94.16 High High
Neuroblastoma 1 91.40 High High
Glioma 1 90.76 High High
Myocardial Infarction 1 90.76 High High
Syndrome 1 88.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of differentiation increases Met5-enkephalin and Leu5-enkephalin content in NG108-15 hybrid cells: an immunocytochemical and biochemical analysis.
Positive_regulation (increases) of Leu5 in NG108-15 associated with enkephalin
1) Confidence 0.49 Published 1983 Journal J. Neurosci. Section Title Doc Link 6193253 Disease Relevance 0.18 Pain Relevance 0.79
The participation of the medullary structures in the total respiratory effect of opiates was studied by restricting the access of the delta-agonist D-ala2-D-leu5-enkephalin and the mu-agonist D-ala2-Me-Phe4-Met (O) ol5-enkephalin, to the ventral medullary surface, and by comparing their responses with those induced after i.c.v. administration.
Positive_regulation (restricting) of leu5 in respiratory associated with agonist, enkephalin and opiate
2) Confidence 0.49 Published 1982 Journal Life Sci. Section Abstract Doc Link 6819420 Disease Relevance 0 Pain Relevance 0.67
[Cardiovascular effects of D-ALA2, LEU5, ARG6-enkephalin (dalargin) are mediated by peripheral mu-opioid receptor activation].
Positive_regulation (mediated) of LEU5 associated with opioid receptor and enkephalin
3) Confidence 0.49 Published 2008 Journal Eksp Klin Farmakol Section Title Doc Link 18488902 Disease Relevance 0.27 Pain Relevance 0.19

General Comments

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