INT4186

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Context Info
Confidence 0.53
First Reported 1976
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.11
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gip) extracellular region (Gip) cytoplasm (Gip)
Anatomy Link Frequency
fat 2
Gip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 10 100.00 Very High Very High Very High
Enkephalin 17 99.84 Very High Very High Very High
narcan 5 98.40 Very High Very High Very High
Chronic pancreatitis 9 97.96 Very High Very High Very High
antagonist 1 97.04 Very High Very High Very High
opioid receptor 1 96.68 Very High Very High Very High
abdominal pain 1 96.16 Very High Very High Very High
Endogenous opioid 1 93.52 High High
Opioid 3 91.56 High High
Neuropeptide 1 89.52 High High
Disease Link Frequency Relevance Heat
Steatorrhea 6 98.68 Very High Very High Very High
Pancreatitis 9 97.96 Very High Very High Very High
Abdominal Pain 1 96.16 Very High Very High Very High
Diabetes Mellitus 8 95.80 Very High Very High Very High
Impaired Glucose Tolerance 7 87.60 High High
Apoptosis 1 82.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reversal of impaired GIP and insulin secretion in patients with pancreatogenic steatorrhea following enzyme substitution.
Negative_regulation (impaired) of Localization (secretion) of GIP associated with steatorrhea
1) Confidence 0.53 Published 1980 Journal Diabetologia Section Title Doc Link 6997121 Disease Relevance 0.50 Pain Relevance 0.13
Vagal stimulation (7 V, 10 Hz, 5 ms) inhibited GIP-stimulated SLI release.
Negative_regulation (inhibited) of Localization (release) of GIP-stimulated SLI associated with somatostatin
2) Confidence 0.43 Published 1983 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6137272 Disease Relevance 0 Pain Relevance 1.14
In chronic pancreatitis endocrine insufficiency may induce an exaggerated GIP response and severe exocrine insufficiency may prevent fat induced GIP release.
Spec (may) Negative_regulation (prevent) of Localization (release) of GIP in fat associated with chronic pancreatitis
3) Confidence 0.41 Published 1976 Journal Diabetologia Section Abstract Doc Link 1001849 Disease Relevance 0.33 Pain Relevance 0.34
Reversal of impaired GIP and insulin secretion in patients with pancreatogenic steatorrhea following enzyme substitution.
Negative_regulation (Reversal) of Localization (secretion) of GIP associated with steatorrhea
4) Confidence 0.39 Published 1980 Journal Diabetologia Section Title Doc Link 6997121 Disease Relevance 0.50 Pain Relevance 0.13
GRP inhibited glucose-stimulated insulin responses, and the insulin responses to glucose plus GIP; unlike galanin, GRP inhibited both glucose- and GIP-stimulated insulin release.
Negative_regulation (inhibited) of Localization (release) of GIP-stimulated
5) Confidence 0.34 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 2445005 Disease Relevance 0 Pain Relevance 0.04
Gastric inhibitory polypeptide (GIP; 1 nM) -stimulated secretion of immunoreactive somatostatin was almost completely inhibited by DAGO (1 microM).
Negative_regulation (inhibited) of Localization (secretion) of Gastric inhibitory polypeptide associated with somatostatin and enkephalin
6) Confidence 0.22 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7982463 Disease Relevance 0 Pain Relevance 0.98
The addition of 200 mg of acarbose to the sucrose load attenuated the sucrose-induced glycaemia and IRI response and completely abolished the IR-GIP release.
Negative_regulation (abolished) of Localization (release) of IR-GIP
7) Confidence 0.14 Published 1981 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 7034156 Disease Relevance 0.10 Pain Relevance 0.10
In such patients, the secretion of GIP is near normal, but its effect on insulin secretion, particularly the late phase, is severely impaired.
Negative_regulation (impaired) of Localization (secretion) of GIP
8) Confidence 0.05 Published 2009 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 18786605 Disease Relevance 0.68 Pain Relevance 0.13

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