INT41873

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Context Info
Confidence 0.39
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.10
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Mbl1) extracellular region (Mbl1)
Mbl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 3 90.76 High High
Neuritis 6 83.88 Quite High
Multiple sclerosis 3 75.00 Quite High
Inflammation 24 64.96 Quite High
ischemia 40 58.68 Quite High
antagonist 10 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 3 95.40 Very High Very High Very High
Demyelinating Disease 6 90.76 High High
Ocular Motility Disorders 3 88.84 High High
Optic Neuritis 6 83.88 Quite High
Apoptosis 2 72.20 Quite High
INFLAMMATION 24 64.96 Quite High
Cv Unclassified Under Development 32 58.68 Quite High
Injury 74 55.36 Quite High
Coronary Artery Disease 14 50.00 Quite Low
Myocarditis 4 44.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar observations by others, also support an Ab-dependent activation of the MBL-dependent lectin pathway [15].
Positive_regulation (activation) of MBL-dependent
1) Confidence 0.39 Published 2010 Journal GMS German Medical Science Section Body Doc Link PMC2940219 Disease Relevance 0.30 Pain Relevance 0.09
While the lectin and alternative complement pathways are historically known to activate complement in an antibody independent manner, our group recently demonstrated that MBL also interacts with IgM to activate the lectin complement pathway [13] and that lectin complement pathway activation in myocardial MI/R is dependent on both MBL and IgM [14].
Positive_regulation (activation) of MBL
2) Confidence 0.39 Published 2010 Journal GMS German Medical Science Section Body Doc Link PMC2940219 Disease Relevance 0.35 Pain Relevance 0.11
MS patients experiencing monosymptomatic exacerbations show elevated CSF-MBP levels in 75% in 75% of cases (mean 8.2 ng/ml).
Positive_regulation (elevated) of CSF-MBP
3) Confidence 0.28 Published 1983 Journal Can J Neurol Sci Section Abstract Doc Link 6197151 Disease Relevance 0.51 Pain Relevance 0.24
Ninety-five percent of MS patients experiencing polysymptomatic exacerbations have elevated levels of CSF-MBP.
Positive_regulation (elevated) of CSF-MBP
4) Confidence 0.28 Published 1983 Journal Can J Neurol Sci Section Abstract Doc Link 6197151 Disease Relevance 0.46 Pain Relevance 0.22
MS patients experiencing polysymptomatic exacerbations show significantly higher levels of CSF-MBP (mean 22.3 ng/ml) than the patients with monosymptomatic exacerbations.
Positive_regulation (levels) of CSF-MBP
5) Confidence 0.19 Published 1983 Journal Can J Neurol Sci Section Abstract Doc Link 6197151 Disease Relevance 0.49 Pain Relevance 0.23

General Comments

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