INT41878

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Context Info
Confidence 0.61
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 5.24
Pain Relevance 3.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (EP300) transferase activity, transferring acyl groups (EP300) DNA binding (EP300)
cytoplasm (EP300) nucleolus (EP300) nucleus (EP300)
Anatomy Link Frequency
Hip 2
B cells 1
lobe 1
respiratory 1
parietal 1
EP300 (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 161 99.82 Very High Very High Very High
opiate 150 99.54 Very High Very High Very High
Anterior cingulate cortex 114 99.54 Very High Very High Very High
Nicotine 177 98.36 Very High Very High Very High
Hippocampus 20 92.36 High High
agonist 55 89.44 High High
Electroencephalography 29 80.24 Quite High
Lasting pain 4 79.00 Quite High
Central grey 1 78.28 Quite High
withdrawal 32 77.60 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 320 99.72 Very High Very High Very High
Nicotine Addiction 75 98.88 Very High Very High Very High
Respiratory Failure 30 98.82 Very High Very High Very High
Cognitive Disorder 175 97.52 Very High Very High Very High
Chronic Lymphoid Leukemia 7 96.20 Very High Very High Very High
Congenital Anomalies 18 93.84 High High
Hypoxia 13 89.92 High High
Mycobacterial Infection 2 89.92 High High
Renal Failure 1 89.24 High High
Encephalopathy 12 88.66 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together with the hypothesis, that opiate and methadone use may increase P300 amplitudes, our data support the notion that effects of nicotine, opiates and effects of additional predisposing factors interact in some complex form [17].
Spec (may) Positive_regulation (increase) of P300 associated with nicotine, methadone and opiate
1) Confidence 0.61 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2198909 Disease Relevance 0.59 Pain Relevance 1.30
Detoxification in opiate addicts has been associated with lowered P300 amplitudes when compared to controls and substitution treatment has been shown to increase P300 amplitudes [13,14].
Positive_regulation (increase) of P300 associated with opiate
2) Confidence 0.44 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2198909 Disease Relevance 0.52 Pain Relevance 0.83
While all patients in our study were smokers, it may be suggested that methadone treatment may have heightened P300 amplitudes to some degree over those of nicotine using control subjects.
Positive_regulation (heightened) of P300 associated with nicotine addiction, nicotine and methadone
3) Confidence 0.44 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2198909 Disease Relevance 0.37 Pain Relevance 0.80
Similarly, rare visual stimuli generated a scalp P300 and negative activity subcortically; both scalp and subcortical waves had a longer latency than in the auditory experiment.
Positive_regulation (generated) of P300
4) Confidence 0.41 Published 1984 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 6198167 Disease Relevance 0.16 Pain Relevance 0.20
As described below, the Hip activity seems to be one of the major sources generating the scalp-recorded P300 (P3b), both of which we measured in this study.
Positive_regulation (generating) of P300 in Hip
5) Confidence 0.28 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2607283 Disease Relevance 0 Pain Relevance 0.21
Possible involvement of the ACC and Hip activities in generating the P300
Positive_regulation (generating) of P300 in Hip associated with anterior cingulate cortex
6) Confidence 0.26 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2607283 Disease Relevance 0.07 Pain Relevance 0.19
While task-relevant deviant stimuli elicit the parietocentral P300 or P3b, task-irrelevant salient stimuli inserted in the repeated target and non-target stimuli under three-stimulus paradigms [66] elicit an earlier positive deflection, the frontocentral P3a or novelty P300 [50,51,67].
Positive_regulation (elicit) of P300
7) Confidence 0.24 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2607283 Disease Relevance 0.10 Pain Relevance 0.08
It is a positive-going potential with a modal latency of 300 ms and centroparietal scalp distribution, obtained usually by the oddball paradigm.21 P300 latency is an index of cognitive processing time and was shown to be prolonged in normal aging, confusional states, and dementia.22–24 P300 latency has been found also to be a sensitive marker of subclinical encephalopathy in hepatic and renal failure.25–28 The effect of acute hypoxia on EREP was studied in an experiment that utilized a simulated high altitude environment, and P300 latency was found to be delayed.29 So far, few studies have described P300 latency abnormalities in chronic respiratory insufficiency.16,17,30 A group of 19 patients with mild or moderate respiratory failure (RF) of different etiologies were studied by Barbieri and colleagues16 and another group of 17 patients with variable severity chronic RF by Nakano and colleagues.17 Although their results show a tendency for P300 changes, these were not significant.
Positive_regulation (tendency) of P300 in respiratory associated with dementia, aging, hypoxia, renal failure, confusion, cognitive disorder, encephalopathy, congenital anomalies and respiratory failure
8) Confidence 0.16 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2846153 Disease Relevance 1.45 Pain Relevance 0
The subject's choice is the stimulus that elicits the largest P300.
Positive_regulation (elicits) of P300
9) Confidence 0.14 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2944670 Disease Relevance 0 Pain Relevance 0
forms an active complex with the transcriptional coactivator p300 and activated Stat3 on the VEGF promoter, which likely explains the anomalous autocrine VEGF secretion from CLL B cells [273].
Positive_regulation (activated) of p300 in B cells associated with chronic lymphoid leukemia
10) Confidence 0.10 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.79 Pain Relevance 0.15
Given the current collection of empirical observations, it seems reasonable to conclude that the amplitude reduction of N1 and P300 after SD and the amplitude enhancement of those components after a dose of caffeine are both related to changes in attention and thus to changes in sensory processing, albeit in opposite directions.
Positive_regulation (reduction) of P300 associated with sleep disorders
11) Confidence 0.10 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.32 Pain Relevance 0.03
Deslandes and colleagues [80] found in an oddball paradigm that administration of a 400-mg dose of caffeine reduced the latency and increased the amplitude of P300.
Positive_regulation (increased) of P300
12) Confidence 0.10 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.33 Pain Relevance 0.03
P300 is associated with frontal lobe functioning and can be elicited by presenting the participant with a visual or auditory stimulus that is either unexpected or highly relevant for the task at hand [78].
Positive_regulation (elicited) of P300 in lobe
13) Confidence 0.09 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.35 Pain Relevance 0.03
It was reported that these infrequent distracters elicit a frontocentral P300, so called P3a, whereas the rare targets elicit a parietal P300, so called P3b (Katayama and Polich 1996, 1998).
Positive_regulation (elicit) of P300 in parietal
14) Confidence 0.06 Published 2008 Journal Appl Psychophysiol Biofeedback Section Body Doc Link PMC2259255 Disease Relevance 0.19 Pain Relevance 0.09

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