INT4188

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Context Info
Confidence 0.46
First Reported 1976
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 3.52
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (NF2) nucleolus (NF2) plasma membrane (NF2)
cytoskeleton (NF2) nucleus (NF2) cytoplasm (NF2)
Anatomy Link Frequency
liver 1
NF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 20 100.00 Very High Very High Very High
antagonist 20 100.00 Very High Very High Very High
Opioid 4 83.92 Quite High
Pain 1 82.40 Quite High
imagery 10 76.44 Quite High
Angina 11 41.04 Quite Low
cva 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 40 99.68 Very High Very High Very High
Bordatella Infection 4 99.16 Very High Very High Very High
Meningioma 130 96.64 Very High Very High Very High
Convulsion 10 94.64 High High
Coronary Artery Disease 67 91.36 High High
Fever 1 83.20 Quite High
Pain 1 82.40 Quite High
Recurrence 10 79.88 Quite High
Cancer 14 79.44 Quite High
Hypesthesia 6 68.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although meningioangiomatosis was originally described in association with NF-2, the recent study by Omeis et al [17] has been revealed that meningioangiomatosis occurred more frequently in sporadic form and only 14 cases (14%) of the 100 reported cases are associated with NF.
NF-2 Binding (association) of
1) Confidence 0.46 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2904739 Disease Relevance 0.55 Pain Relevance 0.04
None of these patients was associated with NF-2.
NF-2 Binding (associated) of
2) Confidence 0.46 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2904739 Disease Relevance 1.57 Pain Relevance 0
Apart from special types encountered in neonates and during pregnancy, spontaneous sub-capsular haematoma (SCH) of the liver is a rare condition which is usually not recognized before operation.
SCH Neg (not) Binding (recognized) of in liver
3) Confidence 0.31 Published 1976 Journal J Radiol Electrol Med Nucl Section Abstract Doc Link 1003380 Disease Relevance 0.17 Pain Relevance 0.08
For instance, the Merlin analysis showed linkage to the MI phenotype on Chromosome 17 (LOD = 3.19; location = 61 cM; ?
Merlin Binding (linkage) of associated with myocardial infarction
4) Confidence 0.12 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1463045 Disease Relevance 0.91 Pain Relevance 0
In addition, SCH-202676 inhibited antagonist binding to the beta2-adrenergic receptor expressed in Escherichia coli, a system devoid of classical heterotrimeric G proteins.
SCH-202676 Binding (binding) of associated with antagonist
5) Confidence 0.01 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11125021 Disease Relevance 0.10 Pain Relevance 0.41
SCH-202676 inhibited radiolabeled agonist and antagonist binding to the alpha2a-adrenergic receptor with an IC50 value of 0.5 microM, decreased the Bmax value of the binding sites with a slight increase in the KD value, and inhibited agonist-induced activation of the receptor.
SCH-202676 Binding (binding) of associated with antagonist and agonist
6) Confidence 0.00 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11125021 Disease Relevance 0.09 Pain Relevance 0.47
Taken together, our data suggest that SCH-202676 has the unique ability to allosterically regulate agonist and antagonist binding to GPCRs in a manner that is both selective and reversible.
SCH-202676 Binding (binding) of associated with antagonist and agonist
7) Confidence 0.00 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11125021 Disease Relevance 0.07 Pain Relevance 0.39
SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors.
SCH-202676 Binding (binding) of associated with antagonist and agonist
8) Confidence 0.00 Published 2001 Journal Mol. Pharmacol. Section Title Doc Link 11125021 Disease Relevance 0.07 Pain Relevance 0.39

General Comments

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