INT4190

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Context Info
Confidence 0.60
First Reported 1976
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 19
Total Number 22
Disease Relevance 4.97
Pain Relevance 7.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 2
neutrophils 2
macrophages 1
colon 1
epithelial cells 1
PGE (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 46 100.00 Very High Very High Very High
calcitonin gene related peptide 10 100.00 Very High Very High Very High
bradykinin 30 99.98 Very High Very High Very High
Neuropeptide 2 99.90 Very High Very High Very High
chemokine 76 99.64 Very High Very High Very High
substance P 15 99.62 Very High Very High Very High
Endocannabinoid 12 99.52 Very High Very High Very High
Inflammation 124 99.44 Very High Very High Very High
COX-2 inhibitor 10 98.72 Very High Very High Very High
Spinal cord 4 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 192 100.00 Very High Very High Very High
Arthritis 3 97.32 Very High Very High Very High
Dysmenorrhea 1 96.96 Very High Very High Very High
Sprains And Strains 172 93.84 High High
Pressure And Volume Under Development 1 90.12 High High
Infection 84 87.88 High High
Chlamydia Infection 376 85.44 High High
Pain 6 82.28 Quite High
Disease 45 77.80 Quite High
Nociception 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: The lack of an analgesic effect for dexamethasone while reducing both PGE(2) and TxB(2) at the site of injury in comparison to ketorolac analgesia accompanied by greater reductions in levels of these prostanoids suggests that glucocorticoids at this dose do not suppress PGE(2) release sufficiently to attenuate peripheral sensitization of nociceptors after tissue injury.


Localization (release) of PGE in nociceptors
1) Confidence 0.60 Published 2003 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 12966473 Disease Relevance 0.05 Pain Relevance 0
Moreover, we examined the effects of paeonol on the release of inflammatory mediators such as NO, PGE(2) and IL-6.
Localization (release) of PGE associated with inflammatory mediators
2) Confidence 0.43 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19222121 Disease Relevance 0.43 Pain Relevance 0.47
Interestingly, COX-2 and its metabolite, the presumably proinflammatory PGE(2), are present in the joints during resolution, and blocking COX-2 activity and PGE(2) production within this period perpetuated, instead of attenuated, inflammation.
Localization (metabolite) of PGE in joints associated with inflammation
3) Confidence 0.43 Published 2010 Journal J. Immunol. Section Abstract Doc Link 20435922 Disease Relevance 0.72 Pain Relevance 0.36
Mechanical distensions in the noxious range (45, 60 and 90 mmHg) evoked a long-linear graded release of CGRP (1.3-, 1.6- and 2.6-fold over baseline) and of PGE(2) (1.9- 3.8-, 12.3-fold over baseline).
Localization (release) of PGE associated with calcitonin gene related peptide
4) Confidence 0.43 Published 2001 Journal Pain Section Abstract Doc Link 11514080 Disease Relevance 0.15 Pain Relevance 0.82
Excised segments of colon from CD mice were immersed in synthetic interstitial fluid (SIF) exposing the serosal surface during 5 min to different types of noxious stimuli; the increase in neuropeptide and PGE(2) release were analyzed (by EIA technique).
Localization (release) of PGE in colon associated with neuropeptide
5) Confidence 0.43 Published 2001 Journal Pain Section Abstract Doc Link 11514080 Disease Relevance 0.22 Pain Relevance 0.81
It appears that the release of PGE and PGF is dependent on uterine stretching and/or the subsequently induced uterine contractions.
Localization (release) of PGE in uterine associated with dismenorea
6) Confidence 0.35 Published 1983 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 6873748 Disease Relevance 0.10 Pain Relevance 0.10
Synthetic substance P was devoid of any PGE releasing action. 6.
Localization (releasing) of PGE associated with substance p
7) Confidence 0.30 Published 1976 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1004630 Disease Relevance 0 Pain Relevance 0.32
Bradykinin in dose dependent amounts released mainly PGE (presumably PGE1) and in much smaller amounts also PGF. 3.
Localization (released) of PGE associated with bradykinin
8) Confidence 0.30 Published 1976 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1004630 Disease Relevance 0 Pain Relevance 0.29
ACh showed a much lower efficacy than bradykinin in releasing PGE and PGF.
Localization (releasing) of PGE associated with bradykinin
9) Confidence 0.30 Published 1976 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1004630 Disease Relevance 0 Pain Relevance 0.32
Bradykinin released similar amounts of PGE in innervated and chronically denervated ears. 4.
Localization (released) of PGE in ears associated with bradykinin
10) Confidence 0.30 Published 1976 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1004630 Disease Relevance 0 Pain Relevance 0.31
Indomethacin completely prevented the PGE release by bradykinin. 5.
Localization (release) of PGE associated with bradykinin
11) Confidence 0.30 Published 1976 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1004630 Disease Relevance 0 Pain Relevance 0.32
Furthermore, purified populations of endometrial cells from the WT mice secreted IL-6, CXCL1, CCL20 and PGE in response to LPS, in a dose and time dependent manner.
Localization (secreted) of PGE
12) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.54 Pain Relevance 0.15
The secretion of PGE from stromal cells stimulated with LPS was not unexpected because PGE is an inflammatory mediator [10].
Localization (secretion) of PGE in stromal cells associated with inflammation
13) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.48 Pain Relevance 0.30
The supernatants from epithelial cells also accumulated IL-6, CXCL1, and CCL20, in a concentration dependent manner for each LPS examined (Fig. 5E–G; ANOVA, P<0.05), although the epithelial cells secreted little PGE (Fig. 5H).
Localization (secreted) of PGE in epithelial cells
14) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.29 Pain Relevance 0.12
This lack of response to LPS was not due to a wider defect in innate immunity because TLR1, TLR2 and TLR9 ligands stimulated secretion of IL-6, CXCL1, CCL20 and PGE from endometrial cells purified from Tlr4?
Localization (secretion) of PGE
15) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.16 Pain Relevance 0.13
We have shown previously that norepinephrine (NE) microdialyzed into the preoptic area (POA) of conscious guinea pigs stimulates local PGE(2) release.
Localization (release) of PGE in POA
16) Confidence 0.15 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14962823 Disease Relevance 0 Pain Relevance 0.29
Prostaglandin E2 (PGE) and interleukin-8 (IL-8) accumulations in media were measured because LPS impacts endometrial cell endocrine and immune function to stimulate secretion of PGE [18], and the chemokine IL-8 attracts neutrophils and macrophages to the endometrium in vivo [24].
Localization (secretion) of PGE in neutrophils associated with chemokine
17) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820550 Disease Relevance 0.17 Pain Relevance 0.09
Endometrial cells challenged with LPS preferentially secrete PGE [18], [19] and the chemokine IL-8, which attracts neutrophils to the endometrium [24].
Localization (secrete) of PGE in neutrophils associated with chemokine
18) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820550 Disease Relevance 0.21 Pain Relevance 0.12
Endometrial cells isolated from wild type mice also secreted PGE and the chemokine CXCL1, which is the murine chemokine similar to IL-8, in response to LPS from EnPEC but not more than the ultrapure LPS.
Neg (not) Localization (secreted) of PGE associated with chemokine
19) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820550 Disease Relevance 0.30 Pain Relevance 0.18
In the present study, we recorded from spinal cord neurons with input from the inflamed knee joint and we measured the spinal release of PGE(2) and the endocannabinoid 2-arachidonoyl glycerol (2-AG) in vivo, using the same stimulation procedures.
Localization (release) of PGE in spinal associated with endocannabinoid and spinal cord
20) Confidence 0.02 Published 2010 Journal Pain Section Abstract Doc Link 19879047 Disease Relevance 0.45 Pain Relevance 1.04

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