INT41916

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Context Info
Confidence 0.21
First Reported 1984
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 13
Disease Relevance 5.73
Pain Relevance 4.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Set) nucleoplasm (Set) endoplasmic reticulum (Set)
nucleus (Set) protein complex (Set) cytoplasm (Set)
Anatomy Link Frequency
dentate gyrus 1
Set (Rattus norvegicus)
Pain Link Frequency Relevance Heat
backache 462 100.00 Very High Very High Very High
narcan 2 99.48 Very High Very High Very High
Cholecystokinin 7 98.94 Very High Very High Very High
Somatostatin 7 98.60 Very High Very High Very High
antagonist 3 98.28 Very High Very High Very High
opioid receptor 2 97.84 Very High Very High Very High
orphanin 3 96.28 Very High Very High Very High
Enkephalin 6 95.36 Very High Very High Very High
Hippocampus 6 94.88 High High
Calcium channel 2 93.92 High High
Disease Link Frequency Relevance Heat
Low Back Pain 469 100.00 Very High Very High Very High
Cognitive Disorder 28 99.14 Very High Very High Very High
Stress 16 97.52 Very High Very High Very High
Spinal Cord Injury 124 96.88 Very High Very High Very High
Hypoxia 288 94.04 High High
Bacterial Infection 6 86.52 High High
INFLAMMATION 104 85.52 High High
Fibrosis 10 81.60 Quite High
Infection 30 77.16 Quite High
Pain 49 53.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These methods were not part of the process when the present Comprehensive Core Set for LBP was developed (Cieza et al 2004).
Gene_expression (present) of Set associated with backache
1) Confidence 0.21 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.55 Pain Relevance 0.55
It is worth to realize this shortcoming when applying the Comprehensive ICF Core Set for LBP in practice.
Gene_expression (applying) of Set associated with backache
2) Confidence 0.21 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.68 Pain Relevance 0.51
This problem applies partly to the ICF classification and partly to the reduction of ICF categories in the present Comprehensive ICF Core Set.
Gene_expression (present) of Set
3) Confidence 0.21 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.40 Pain Relevance 0.40
It was then assessed whether these categories were contained in the Comprehensive Core Set for LBP.


Gene_expression (contained) of Set associated with backache
4) Confidence 0.21 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.25 Pain Relevance 0.25
These problems may be linked to ICF categories b144 Memory functions and b164 Higher-level cognitive functions, which were not included in the present ICF Core Set.
Neg (not) Gene_expression (present) of Set associated with cognitive disorder
5) Confidence 0.21 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.52 Pain Relevance 0.42
ODI is scored on a six point Likert scale whereas WHODAS II and the Comprehensive ICF Core Set for LBP are scored on five point scales.
Gene_expression (scored) of Set associated with backache
6) Confidence 0.21 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.15 Pain Relevance 0.15
As several of the items in WHODAS II were linked to more than one ICF category, this resulted in additionally 11 items in WHODAS II not being covered by the Comprehensive ICF Core Set for LBP (Tables 2, 3 and 4).
Neg (not) Gene_expression (covered) of Set associated with backache
7) Confidence 0.21 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.50 Pain Relevance 0.44
These results demonstrate that endomorphin 1 and 2 produce significant naloxone-sensitive decreases in systemic arterial pressure.
Gene_expression (produce) of endomorphin 1 and 2 associated with narcan
8) Confidence 0.14 Published 1998 Journal Life Sci. Section Abstract Doc Link 9519803 Disease Relevance 0 Pain Relevance 0.74
A closer look into the data set revealed that LOX was represented in the microarray set with two identifiers (“S66184_s_at” and “rc_AA875582_at”, Table 1).
Gene_expression (revealed) of set
9) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 1.08 Pain Relevance 0.25
A closer look into the data set revealed that LOX was represented in the microarray set with two identifiers (“S66184_s_at” and “rc_AA875582_at”, Table 1).
Gene_expression (represented) of set
10) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 1.06 Pain Relevance 0.24
Gene set enrichment analysis
Gene_expression (analysis) of set
11) Confidence 0.13 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.24 Pain Relevance 0
Gene set enrichment analysis
Gene_expression (analysis) of set
12) Confidence 0.13 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.29 Pain Relevance 0.05
Vasoactive intestinal polypeptide and cholecystokinin-octapeptide-positive cell bodies were predominantly located in the stratum moleculare and stratum radiatum of CA 1-2 regions and dentate gyrus, whilst somatostatin-containing cell bodies were found mainly in the stratum oriens.
Gene_expression (located) of 1-2 in dentate gyrus associated with somatostatin and cholecystokinin
13) Confidence 0.06 Published 1984 Journal Neuroscience Section Abstract Doc Link 6200800 Disease Relevance 0 Pain Relevance 0.96

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