INT4195

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Context Info
Confidence 0.44
First Reported 1976
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 23
Disease Relevance 2.88
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ces1c) endoplasmic reticulum (Ces1c)
Anatomy Link Frequency
sperm 5
epididymis 3
epithelial cell 2
cauda epididymis 1
Ces1c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 15 99.28 Very High Very High Very High
Inflammatory response 2 86.48 High High
qutenza 1 85.20 High High
bradykinin 2 81.24 Quite High
anesthesia 40 79.60 Quite High
Inflammation 7 75.00 Quite High
Sciatic nerve 1 25.40 Quite Low
antagonist 18 5.00 Very Low Very Low Very Low
Central nervous system 13 5.00 Very Low Very Low Very Low
Hippocampus 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 143 99.88 Very High Very High Very High
Body Weight 51 94.80 High High
Sprains And Strains 3 87.68 High High
Immunization 17 82.64 Quite High
Emergencies 17 81.56 Quite High
Male Infertility 34 79.68 Quite High
Sperm Disorder 68 75.24 Quite High
INFLAMMATION 7 75.00 Quite High
Decapitation 6 68.24 Quite High
Congenital Anomalies 52 56.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that part of the action of histamine, adenosine-5'-triphosphate and prostagland in E1 is produced indirectly by releaseor stimulation of the synthesis of prostaglandins or their precursors.
Gene_expression (produced) of E1 associated with adenocard
1) Confidence 0.44 Published 1976 Journal Br J Exp Pathol Section Abstract Doc Link 1008999 Disease Relevance 0.07 Pain Relevance 0.38
The levels of E1 and E2 decreased to near or below the level of quantification.
Gene_expression (levels) of E1
2) Confidence 0.20 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206728 Disease Relevance 0 Pain Relevance 0
Results of E1 and E2 are similar, but differ significantly from NC group (P?
Gene_expression (Results) of E1
3) Confidence 0.14 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2249733 Disease Relevance 0.09 Pain Relevance 0
Group C was normal control group administered distilled water; group E1 was the experimental group receiving the plant extract (40 mg kg?
Gene_expression (was) of E1
4) Confidence 0.14 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2249733 Disease Relevance 0.42 Pain Relevance 0.07
Group C was normal control group administered distilled water; group E1 was the experimental group receiving the plant extract (40 mg kg?
Gene_expression (group) of E1
5) Confidence 0.14 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2249733 Disease Relevance 0.42 Pain Relevance 0.07
The relevant proteins include three D-type cyclins (D1, D2, and D3) that, in different combinations, bind to and allosterically regulate one of two cdk subunits, cdk4 and cdk6, as well as the E-type cyclins (E1 and E2), which govern the activity of a single catalytic subunit, cdk2 [176].
Gene_expression (one) of E1
6) Confidence 0.09 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0 Pain Relevance 0
Thus, we decided to use RNAi approach to knock down HongrES1 gene expression in rat epididymis.
Gene_expression (expression) of HongrES1 in epididymis associated with targeted disruption
7) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0.24 Pain Relevance 0
HongrES1 expression is androgen-dependent and developmentally regulated
Gene_expression (expression) of HongrES1
8) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0 Pain Relevance 0
Figure 4A shows that both siRNAs could inhibit HongrES1 expression almost completely at the mRNA and protein levels at 48 h after transfection.
Gene_expression (expression) of HongrES1
9) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0.19 Pain Relevance 0
We were therefore keen to examine the fertilizing capacity of spermatozoa from rats in which HongrES1 gene expression was knocked down and evaluate the effect of accelerated capacitation that takes place when the apparent inhibitory action of this protein was blocked.
Gene_expression (expression) of HongrES1 in spermatozoa
10) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0.20 Pain Relevance 0
Each siRNA with HongrES1 complementary DNA was co-transfected into the mouse epididymal epithelial cell line (PC1), which had no endogenous HongrES1 expression.
Neg (no) Gene_expression (expression) of HongrES1 in epithelial cell
11) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0.19 Pain Relevance 0
Here, we provide direct evidence in vivo that HongrES1, a new member of the SERPIN family and specifically expressing in the principal cells of the cauda epididymis, is involved in sperm capacitation.
Gene_expression (expressing) of HongrES1 in sperm
12) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0 Pain Relevance 0
Since the epididymis is an androgen-responsive organ [16], the effects of androgen manipulation on HongrES1 mRNA expression were investigated in the castrated rat by northern blot analysis (Figure 2A).
Gene_expression (expression) of HongrES1 mRNA in epididymis
13) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0 Pain Relevance 0
This result indicates that HongrES1 mRNA expression was up-regulated by androgen in vivo.
Gene_expression (expression) of HongrES1 mRNA
14) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0 Pain Relevance 0
The developmental changes of HongrES1 expression at both mRNA and protein levels throughout the life-span of rats were surveyed by northern blot and western blot analysis (Figure 2C, 2D and 2E).
Gene_expression (expression) of HongrES1
15) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0 Pain Relevance 0
The expression profile of HongrES1 in the rat epididymis during the whole life-span was monitored as previously described procedure [27], [48], the epdidymides of normal male Sprague-Dawley rats were sampled at the age of 15, 30, 45, 60, 90, 120, 270, 360, 450 and 720 days.
Gene_expression (expression) of HongrES1 in epididymis
16) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0.09 Pain Relevance 0.08
Western blot analysis shows that tyrosine phosphorylation of sperm proteins was accelerated when HongrES1 expression was down-regulated by RNAi (Figure 4I).
Gene_expression (expression) of HongrES1 in sperm
17) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0.15 Pain Relevance 0
Here we report that HongrES1, a new member of the SERPIN (serine proteinase inhibitor) family exclusively expressed in the rat cauda epididymis and up-regulated by androgen, is secreted into the lumen and covers the sperm head.
Gene_expression (expressed) of HongrES1 in cauda epididymis
18) Confidence 0.06 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2606034 Disease Relevance 0 Pain Relevance 0
To address these questions, active HongrES1 recombinant protein expression will be a key step in further studies.


Gene_expression (expression) of HongrES1
19) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0.21 Pain Relevance 0
Northern blot and in situ hybridization assays had indicated that HongrES1 mRNA was specifically expressed in the rat cauda epididymis and restricted to the epithelial cells [15].
Gene_expression (expressed) of HongrES1 mRNA in epithelial cells
20) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0.08 Pain Relevance 0

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