INT4196

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Context Info
Confidence 0.03
First Reported 1976
Last Reported 1980
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
striatum 1
Gm4602 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 2 98.68 Very High Very High Very High
fluoxetine 1 97.76 Very High Very High Very High
Raphe 6 96.96 Very High Very High Very High
Serotonin 4 95.92 Very High Very High Very High
antagonist 1 80.40 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of fentanyl, droperidol, and morphine on tyrosine hydroxylation in the rat striatum was measured after inhibition of aromatic amino acid decarboxylase with R04-4602.
Negative_regulation (inhibition) of R04-4602 in striatum associated with morphine
1) Confidence 0.03 Published 1976 Journal Exp Brain Res Section Abstract Doc Link 1010005 Disease Relevance 0 Pain Relevance 0.18
The p-chlorophenylalanine effect can be partially reversed by Ro4-4602, a peripherally acting decarboxylase inhibitor, plus 5-hydroxytryptophan.
Negative_regulation (inhibitor) of Ro4-4602
2) Confidence 0.01 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6104727 Disease Relevance 0 Pain Relevance 0.52

General Comments

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