INT41962

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Context Info
Confidence 0.37
First Reported 1984
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.18
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
mast cells 2
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 1 99.90 Very High Very High Very High
ischemia 16 33.68 Quite Low
qutenza 8 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 5 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
ASIC 2 5.00 Very Low Very Low Very Low
tissue acidosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 146 98.22 Very High Very High Very High
Cv Unclassified Under Development 14 33.68 Quite Low
Acidosis 3 5.00 Very Low Very Low Very Low
Alkalosis 2 5.00 Very Low Very Low Very Low
Coronary Artery Disease 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Exsanguination 1 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of mast cells with lidocaine, an inhibitor of Ca2+ binding to phospholipid, or with nordihydroguaiaretic acid, an inhibitor of Ca2+ flux and lipoxygenase, stimulated arachidonic acid-induced histamine release.
Negative_regulation (inhibitor) of Ca2 Binding (binding) of in mast cells associated with lidocaine
1) Confidence 0.37 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6203535 Disease Relevance 0 Pain Relevance 0.10
Anoxia also significantly reduced Ca2+ clearance via both the SERCA and PMCA and substantially slowed Ca2+ recycling from the mitochondrion (probably as a consequence of inhibition of SERCA and PMCA).
Negative_regulation (slowed) of Ca2 Binding (recycling) of associated with hypoxia
2) Confidence 0.36 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.18 Pain Relevance 0

General Comments

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