INT41984

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Context Info
Confidence 0.44
First Reported 1984
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.18
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HSD11B1) oxidoreductase activity (HSD11B1) endoplasmic reticulum (HSD11B1)
Anatomy Link Frequency
lymphatic system 4
HSD11B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
beta blocker 3 97.20 Very High Very High Very High
Clonidine 1 72.24 Quite High
transdermal 30 65.24 Quite High
depression 26 5.00 Very Low Very Low Very Low
antidepressant 8 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
sSRI 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 97 100.00 Very High Very High Very High
Malignant Neoplastic Disease 4 99.28 Very High Very High Very High
Hepatotoxicity 8 98.28 Very High Very High Very High
Hypogonadotropic Hypogonadism 84 80.96 Quite High
Nicotine Addiction 28 79.28 Quite High
Reprotox - General 3 28 55.28 Quite High
Metabolic Syndrome 66 50.00 Quite Low
Obesity 20 32.00 Quite Low
Stress 30 25.56 Quite Low
Reprotox - General 1 54 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A tendency for increased Tg levels and lower HDL-C concentrations was apparent during combined thiazide-type diuretic-beta-blocker treatment; these changes resembled those observed during beta-blocker monotherapy.
Regulation (tendency) of Gene_expression (levels) of HDL associated with beta blocker and disorder of lipid metabolism
1) Confidence 0.44 Published 1984 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6204152 Disease Relevance 0.27 Pain Relevance 0.17
There were no changes in HDL cholesterol, cholesterol/HDL ratio and triglycerides from baseline to week 8.
Neg (no) Regulation (changes) of Gene_expression (ratio) of HDL associated with disorder of lipid metabolism
2) Confidence 0.27 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831093 Disease Relevance 1.42 Pain Relevance 0
There were no changes in HDL cholesterol, cholesterol/HDL ratio and triglycerides from baseline to week 8.
Neg (no) Regulation (changes) of Gene_expression (ratio) of HDL associated with disorder of lipid metabolism
3) Confidence 0.27 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831093 Disease Relevance 1.42 Pain Relevance 0
The oral form of 17-alpha-alkylated androgen should not be used because of their potential liver toxicity including the development of benign and malignant neoplasm61 in addition deleterious effects on levels of both LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C).62 Testosterone undecanoate, which is absorbed predominantly through the lymphatic system, is widely used outside the United States and has the best safety data.
Regulation (effects) of Gene_expression (levels) of HDL in lymphatic system associated with malignant neoplastic disease, hepatotoxicity and disorder of lipid metabolism
4) Confidence 0.16 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701485 Disease Relevance 0.53 Pain Relevance 0.03
The oral form of 17-alpha-alkylated androgen should not be used because of their potential liver toxicity including the development of benign and malignant neoplasm61 in addition deleterious effects on levels of both LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C).62 Testosterone undecanoate, which is absorbed predominantly through the lymphatic system, is widely used outside the United States and has the best safety data.
Regulation (effects) of Gene_expression (levels) of HDL in lymphatic system associated with malignant neoplastic disease, hepatotoxicity and disorder of lipid metabolism
5) Confidence 0.16 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701485 Disease Relevance 0.53 Pain Relevance 0.03

General Comments

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