INT41988

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Context Info
Confidence 0.02
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.28
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFS1) mitochondrion (NFS1) small molecule metabolic process (NFS1)
nucleus (NFS1) protein complex assembly (NFS1) cytoplasm (NFS1)
Anatomy Link Frequency
Notch 1
NFS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 9 99.80 Very High Very High Very High
Inflammation 2 22.96 Low Low
tolerance 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 7 99.80 Very High Very High Very High
Lifespan 82 99.60 Very High Very High Very High
Aging 24 94.84 High High
Sickle Cell Anemia 1 82.80 Quite High
Intestinal Cancer 14 81.56 Quite High
Salivary Gland Disease 8 65.60 Quite High
Stress 29 62.60 Quite High
Injury 1 25.00 Low Low
INFLAMMATION 2 22.96 Low Low
Cleidocranial Dysplasia 23 15.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increase in the number of irreversibly sickled cells (ISCs) in pain crisis has been found by some investigators but not others.
Positive_regulation (increase) of ISCs associated with pain
1) Confidence 0.02 Published 1984 Journal Blood Section Abstract Doc Link 6204702 Disease Relevance 0.49 Pain Relevance 0.40
Ectopic activation of Notch signaling in ISCs was previously shown to irreversibly impair their function by promoting differentiation [43], [49].
Positive_regulation (activation) of ISCs in Notch
2) Confidence 0.01 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954830 Disease Relevance 0.80 Pain Relevance 0

General Comments

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