INT4199

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Context Info
Confidence 0.48
First Reported 1976
Last Reported 2011
Negated 1
Speculated 3
Reported most in Abstract
Documents 76
Total Number 79
Disease Relevance 21.06
Pain Relevance 12.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) aging (Agt) extracellular region (Agt)
extracellular matrix organization (Agt)
Anatomy Link Frequency
brain 5
nucleus 4
kidney 2
cerebellum 2
gonadotroph 2
Agt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 206 100.00 Very High Very High Very High
Dopamine 40 100.00 Very High Very High Very High
Neurotransmitter 39 100.00 Very High Very High Very High
substance P 34 100.00 Very High Very High Very High
gABA 31 100.00 Very High Very High Very High
Enkephalin 21 100.00 Very High Very High Very High
Serotonin 11 100.00 Very High Very High Very High
Opioid 10 100.00 Very High Very High Very High
Endogenous opioid 4 100.00 Very High Very High Very High
Analgesic 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 34 100.00 Very High Very High Very High
Pancreatitis 3 99.78 Very High Very High Very High
Cancer 64 99.72 Very High Very High Very High
Urological Neuroanatomy 8 99.10 Very High Very High Very High
Hypertension 744 99.08 Very High Very High Very High
Stress 140 98.60 Very High Very High Very High
Body Weight 9 98.54 Very High Very High Very High
Renal Disease 39 98.40 Very High Very High Very High
Natriuresis 29 98.28 Very High Very High Very High
Increased Venous Pressure Under Development 48 97.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Renal vascular interaction of angiotensin II and prostaglandins in renovascular hypertension.
angiotensin II Binding (interaction) of associated with anesthesia and hypertension
1) Confidence 0.48 Published 1999 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 10413062 Disease Relevance 0.53 Pain Relevance 0.12
Therefore, Ang II receptor antagonists interact with IGRS in rat forebrain cardiovascular areas only at high concentrations.
Ang II Binding (interact) of in forebrain associated with antagonist
2) Confidence 0.48 Published 1996 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8877590 Disease Relevance 0 Pain Relevance 0.27
Treatment of OVX rats with E(2) and P induced a significant increase in the Ang II receptor binding (fmol/mg protein) in the MnPO (OVX: 4.48 +/- 0.58 and OVXE(2)P: 9.89 +/- 1.65), LC (OVX: 2.72 +/- 0.37 and OVXE(2)P: 8.03 +/- 0.9) and SFO (OVX: 5.45 +/- 0.66 and OVXE(2)P: 10.73 +/- 1.79) compared to OVX animals treated with the vehicle, P < 0.05.
Ang II Binding (binding) of in SFO associated with locus ceruleus
3) Confidence 0.48 Published 2005 Journal Brain Res. Section Abstract Doc Link 16297888 Disease Relevance 0.09 Pain Relevance 0.33
Also, the FITC-labeled Ang IV binding was not affected by the addition of excessive amount of Sarile (Fig. 1C,F,I), which saturated the AT1 and AT2 binding sites.
Ang IV Binding (binding) of
4) Confidence 0.46 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.36 Pain Relevance 0
Angiotensin II: nitric oxide interaction and the distribution of blood flow.
Angiotensin II Binding (interaction) of in blood
5) Confidence 0.45 Published 1993 Journal Am. J. Physiol. Section Title Doc Link 8285267 Disease Relevance 0.15 Pain Relevance 0.15
Using radioactive microspheres and the substrate antagonist N omega-nitro-L-arginine methyl ester (L-NAME) (10 mg/kg) to block NO synthesis, we tested the hypothesis that there is a significant interaction between the vasodilator NO and the vasoconstrictor angiotensin II, which regulates regional hemodynamics.
angiotensin II Neg (NO) Binding (interaction) of associated with antagonist
6) Confidence 0.45 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8285267 Disease Relevance 0.18 Pain Relevance 0.17
Evidence for an antagonistic angiotensin II/alpha 2-adrenoceptor interaction in the nucleus tractus solitarii.
angiotensin II Binding (interaction) of in nucleus
7) Confidence 0.44 Published 1994 Journal Eur. J. Pharmacol. Section Title Doc Link 7813592 Disease Relevance 0 Pain Relevance 0.32
This study provides support for the idea that blood borne Ang II, bound at cerebral sites posterior to the hypothalamic region, continues to have cardiovascular effects for approximately 20 min after the concentration in the blood has returned to pre-infusion level.
Ang II Binding (bound) of in posterior
8) Confidence 0.42 Published 1995 Journal Acta Physiol. Scand. Section Abstract Doc Link 8719262 Disease Relevance 0.13 Pain Relevance 0.08
After removing the dosing medium, myocytes were washed three times with ice-cold PBS and one time with 0.05 M glycine-HCl (pH 4) to remove the membrane bound 125I-Ang.
125I-Ang Binding (bound) of in myocytes
9) Confidence 0.42 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.06 Pain Relevance 0
Interactions between alpha 2-adrenoceptors and angiotensin II receptors were evaluated in the nucleus tractus solitarii of the rat by means of quantitative receptor autoradiography and cardiovascular analysis.
angiotensin II Binding (Interactions) of in nucleus
10) Confidence 0.39 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7813592 Disease Relevance 0 Pain Relevance 0.18
The final shaping of AngII signaling depends on cross-talk between nNOS and AngII receptors at both molecular and protein levels.
AngII Binding (cross-talk) of
11) Confidence 0.37 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15519680 Disease Relevance 0.36 Pain Relevance 0.06
Assessment of angiotensin II binding sites in the solitary-vagal complex 24 hours after denervation showed a 13% reduction in angiotensin receptors.
angiotensin Binding (Assessment) of
12) Confidence 0.37 Published 1990 Journal Hypertension Section Abstract Doc Link 2298474 Disease Relevance 0.15 Pain Relevance 0.18
Effects of microinjection of angiotensin II and captopril to VTA on morphine self-administration in rats.
angiotensin II Binding (microinjection) of associated with morphine
13) Confidence 0.37 Published 2009 Journal Acta. Biol. Hung. Section Title Doc Link 19700383 Disease Relevance 0 Pain Relevance 0.53
As in their study, Ang-(1–12) as an extended form of Ang I, might bind to a low affinity receptor or alternatively to the same angiotensinogen receptor characterized by Yayama et al., [26] and Pan et al. [25].
angiotensinogen receptor Spec (might) Binding (bind) of
14) Confidence 0.37 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.37 Pain Relevance 0
Experiments were performed three or more times and the enzyme activity values were reported as fmoles of Ang product formation from 125I-Ang-(1–12) substrate per min per mg protein (fmol·mg protein?
Ang Binding (formation) of
15) Confidence 0.37 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.13 Pain Relevance 0
This new observation is in keeping with the demonstration of an important role for mast cell derived chymase in Ang II formation following either decreased expression [29] or pharmacological blockade of ACE [30] This finding also agrees with Prosser et al. [29] report that chymostatin completely inhibited Ang II formation from Ang-(1–12).
Ang II Binding (formation) of in mast cell
16) Confidence 0.37 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.26 Pain Relevance 0
Ang II and the nonpeptide AT1 and AT2 antagonists did not significantly compete for specific [125I]AMIPI binding in either brain region at concentrations of 10 microM (< 20% competition with each compound), which is 10- to 100-fold higher than the concentration necessary to compete completely for their respective Ang II receptor subtypes.
Ang II Binding (compete) of in brain associated with antagonist
17) Confidence 0.37 Published 1996 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8877590 Disease Relevance 0 Pain Relevance 0.30
Ang II and the nonpeptide AT1 and AT2 antagonists did not significantly compete for specific [125I]AMIPI binding in either brain region at concentrations of 10 microM (< 20% competition with each compound), which is 10- to 100-fold higher than the concentration necessary to compete completely for their respective Ang II receptor subtypes.
Ang II Binding (compete) of in brain associated with antagonist
18) Confidence 0.37 Published 1996 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8877590 Disease Relevance 0 Pain Relevance 0.28
NSAIDs inhibit the synthesis of prostaglandins, and consequently vasoconstriction of the afferent arteriole leads to lowering of the glomerular filtration rate (GFR); captopril blocks the formation of angiotensin II (which also leads to a lower GFR), and should be used with caution in patients with stenotic renal arteries; cyclosporin causes vasoconstriction of the afferent arteriole, which is probably mediated by the sympathetic system.
angiotensin II Binding (formation) of in sympathetic associated with cinod and increased venous pressure under development
19) Confidence 0.36 Published 1991 Journal Drug Saf Section Abstract Doc Link 2043284 Disease Relevance 1.18 Pain Relevance 0.26
Non-specific bindings were assessed in sections with the non-labeled Ang IV and the specific bindings of Ang IV were demonstrated in sections with Sarile that is not readily metabolized to Ang III and Ang IV.


Ang IV Binding (metabolized) of
20) Confidence 0.36 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0 Pain Relevance 0

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