INT42015

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Context Info
Confidence 0.10
First Reported 1980
Last Reported 2002
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.81
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Prss3) extracellular space (Prss3) extracellular region (Prss3)
Prss3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 11 99.80 Very High Very High Very High
Cholecystokinin 1 89.84 High High
anesthesia 2 75.08 Quite High
methadone 3 75.00 Quite High
Bile 1 71.32 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 11 99.80 Very High Very High Very High
Body Weight 2 75.96 Quite High
Pancreatic Fistula 1 72.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the pancreatic tissue: (a) total protein decreased (-10 p. 100, p less than 0.01) as well as amylase (-30 p. 100 p less than 0.001), lipase (-19 p. 100, p less than 0.01) and trypsinogen (-9 p. 100, NS); (b) concentrations of DNA and RNA were unsignificantly increased; (c) histological structure was normal in optical microscopy. 3.
Negative_regulation (decreased) of trypsinogen
1) Confidence 0.10 Published 1980 Journal J Pharmacol Section Abstract Doc Link 7206731 Disease Relevance 0.13 Pain Relevance 0.33
Diet II reduced the pancreatic content of trypsinogen and protein.
Negative_regulation (reduced) of trypsinogen
2) Confidence 0.05 Published 1984 Journal Hepatogastroenterology Section Abstract Doc Link 6207085 Disease Relevance 0.14 Pain Relevance 0.16
Using a newly developed PSTI-I ELISA, we can show that the PSTI-I/trypsinogen ratio is not decreased but rather increased in WBN/Kob rats compared to healthy Wistar rats.
Neg (not) Negative_regulation (decreased) of trypsinogen
3) Confidence 0.05 Published 2002 Journal Pancreatology Section Body Doc Link 12123090 Disease Relevance 0.09 Pain Relevance 0
To explore the possibility that PSTI may be secreted at lower levels or contain a mutation in the WBN/Kob rat, we investigated the masses of PSTI-I and -II and asked whether the ratio of PSTI/trypsinogen is decreased in animals with CP.
Spec (whether) Negative_regulation (decreased) of trypsinogen associated with chronic pancreatitis
4) Confidence 0.02 Published 2002 Journal Pancreatology Section Abstract Doc Link 12123090 Disease Relevance 0.44 Pain Relevance 0.44

General Comments

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