INT42039

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1984
Last Reported 2007
Negated 0
Speculated 2
Reported most in Abstract
Documents 11
Total Number 14
Disease Relevance 8.40
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Spink1)
Spink1 (Rattus norvegicus)
Spink1 - N34S (1)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 35 99.08 Very High Very High Very High
Inflammation 2 99.00 Very High Very High Very High
alcohol 1 95.76 Very High Very High Very High
fibrosis 4 95.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 91 100.00 Very High Very High Very High
INFLAMMATION 2 99.00 Very High Very High Very High
Sinusitis 1 98.92 Very High Very High Very High
Cystic Fibrosis 4 95.12 Very High Very High Very High
Hyperamylasemia 3 94.08 High High
Intestinal Obstruction 3 93.24 High High
Diabetes Mellitus 5 92.80 High High
Calcification 3 92.24 High High
Ulcers 3 92.16 High High
Disease 6 91.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Contrary to our hypothesis, PSTI was also upregulated.
Positive_regulation (upregulated) of PSTI
1) Confidence 0.67 Published 2000 Journal Pancreas Section Abstract Doc Link 10975713 Disease Relevance 0.21 Pain Relevance 0.10
Low PSTI levels might cause a lack of protection from prematurely activated trypsin and therefore enhance the risk for pancreatic inflammation.
Spec (might) Positive_regulation (enhance) of PSTI associated with inflammation
2) Confidence 0.48 Published 2000 Journal Pancreas Section Abstract Doc Link 10975713 Disease Relevance 0.26 Pain Relevance 0.13
Using a newly developed PSTI-I ELISA, we can show that the PSTI-I/trypsinogen ratio is not decreased but rather increased in WBN/Kob rats compared to healthy Wistar rats.
Positive_regulation (increased) of PSTI-I
3) Confidence 0.47 Published 2002 Journal Pancreatology Section Body Doc Link 12123090 Disease Relevance 0.09 Pain Relevance 0
Recently an association was identified between idiopathic pancreatitis in the USA and Europe and mutations in the serine protease inhibitor, Kazal type 1 (SPINK1) gene (previously termed pancreatic secretory trypsin inhibitor, PSTI).
Positive_regulation (termed) of SPINK1 associated with pancreatitis
4) Confidence 0.43 Published 2001 Journal Pancreatology Section Abstract Doc Link 12120202 Disease Relevance 0.87 Pain Relevance 0.08
The entire SPINK1 gene was sequenced in these patients.
Positive_regulation (sequenced) of SPINK1 gene
5) Confidence 0.43 Published 2001 Journal Pancreatology Section Body Doc Link 12120202 Disease Relevance 0.09 Pain Relevance 0
[Mutations of SPINK1 and PRSS1 gene in Korean patients with chronic pancreatitis].
Positive_regulation ([Mutations) of SPINK1 associated with chronic pancreatitis
6) Confidence 0.42 Published 2004 Journal Korean J Gastroenterol Section Title Doc Link 15329520 Disease Relevance 0.61 Pain Relevance 0.51
Variations in the SPINK1 gene (encoding pancreatic secretory trypsin inhibitor (PSTI)) are associated with chronic pancreatitis.
Positive_regulation (Variations) of SPINK1 gene associated with chronic pancreatitis
7) Confidence 0.41 Published 2007 Journal Eur. J. Hum. Genet. Section Abstract Doc Link 17568390 Disease Relevance 0.17 Pain Relevance 0.10
These mutations, as with those of the SPINK1 (or PSTI) gene, are prevalent in North America; thus, the presence of such a mutation in an asymptomatic person does not confer a high risk of developing pancreatitis.
Positive_regulation (those) of SPINK1 associated with pancreatitis
8) Confidence 0.40 Published 2003 Journal Can. J. Gastroenterol. Section Abstract Doc Link 12560855 Disease Relevance 0.99 Pain Relevance 0.30
The N34S mutation represents the most frequently observed pancreatitis-associated SPINK1 variant.
Spec (observed) Positive_regulation (pancreatitis-associated) of SPINK1 associated with pancreatitis
9) Confidence 0.37 Published 2004 Journal Gastroenterol. Clin. North Am. Section Abstract Doc Link 15528018 Disease Relevance 0.84 Pain Relevance 0.43
Variations in the SPINK1 gene (encoding pancreatic secretory trypsin inhibitor (PSTI)) are associated with chronic pancreatitis.
Positive_regulation (Variations) of PSTI associated with chronic pancreatitis
10) Confidence 0.36 Published 2007 Journal Eur. J. Hum. Genet. Section Abstract Doc Link 17568390 Disease Relevance 0.17 Pain Relevance 0.10
Of 2 patients who underwent partial pancreatectomy, the serum PSTI level increased markedly in one who developed postoperative pancreatitis but not in the other without pancreatitis.
Positive_regulation (increased) of serum PSTI associated with pancreatitis
11) Confidence 0.36 Published 1984 Journal Clin. Chim. Acta Section Abstract Doc Link 6209036 Disease Relevance 1.16 Pain Relevance 0.15
These results suggest that measurement of serum PSTI concentration may be useful in the diagnosis of acute pancreatitis and that the degree of rise and the duration of the elevated levels of serum PSTI are closely related to the severity of acute pancreatitis.
Positive_regulation (elevated) of serum PSTI associated with pancreatitis
12) Confidence 0.24 Published 1984 Journal Clin. Chim. Acta Section Abstract Doc Link 6209036 Disease Relevance 0.99 Pain Relevance 0.14
Patients with acute pancreatitis in whom the elevation of serum PSTI was transient and occurred after that of serum amylase activity had relatively mild symptoms and recovered along with normalization of serum PSTI levels.
Positive_regulation (elevation) of serum PSTI associated with pancreatitis
13) Confidence 0.24 Published 1984 Journal Clin. Chim. Acta Section Abstract Doc Link 6209036 Disease Relevance 1.06 Pain Relevance 0.09
In idiopathic pancreatitis a significant increase was found in mutation frequency both in the CFTR gene (13%) and N34S mutation in the PSTI gene (3.9%), as well as an increase in familial disposition to pancreatic disorders.
Positive_regulation (increase) of PSTI gene (N34S) associated with pancreatitis
14) Confidence 0.16 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12452372 Disease Relevance 0.87 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox