INT4208

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Context Info
Confidence 0.44
First Reported 1976
Last Reported 2011
Negated 1
Speculated 3
Reported most in Abstract
Documents 23
Total Number 26
Disease Relevance 6.72
Pain Relevance 6.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Got1) biosynthetic process (Got1) cellular amino acid metabolic process (Got1)
lysosome (Got1) cytoplasm (Got1)
Anatomy Link Frequency
plasma 2
liver 2
leaf 2
body 1
Got1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 71 100.00 Very High Very High Very High
corticosteroid 70 100.00 Very High Very High Very High
Glutamate 27 100.00 Very High Very High Very High
gABA 7 100.00 Very High Very High Very High
anesthesia 5 99.72 Very High Very High Very High
addiction 5 99.24 Very High Very High Very High
Opioid 4 99.04 Very High Very High Very High
Morphine 7 98.28 Very High Very High Very High
Gabapentin 2 98.24 Very High Very High Very High
Lamotrigine 2 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Congenital Anomalies 9 99.92 Very High Very High Very High
Opiate Addiction 4 99.24 Very High Very High Very High
Hepatotoxicity 24 98.84 Very High Very High Very High
Injury 30 98.72 Very High Very High Very High
Jaundice 3 98.56 Very High Very High Very High
Encephalopathy 1 97.60 Very High Very High Very High
Drug-induced Liver Injury 1 96.76 Very High Very High Very High
Syndrome 3 96.44 Very High Very High Very High
Disorder Of Lipid Metabolism 1 95.76 Very High Very High Very High
Necrosis 8 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of A. indica leaf extract on serum enzyme levels (glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, acid phosphatase and alkaline phosphatase) elevated by paracetamol in rats was studied with a view to observe any possible hepatoprotective effect of this plant.
Regulation (Effect) of transaminase in leaf associated with paracetamol and glutamate
1) Confidence 0.44 Published 1992 Journal Indian J. Exp. Biol. Section Abstract Doc Link 1459654 Disease Relevance 0 Pain Relevance 0.49
Effect of A. indica leaf extract on serum enzyme levels (glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, acid phosphatase and alkaline phosphatase) elevated by paracetamol in rats was studied with a view to observe any possible hepatoprotective effect of this plant.
Regulation (Effect) of transaminase in leaf associated with paracetamol and glutamate
2) Confidence 0.44 Published 1992 Journal Indian J. Exp. Biol. Section Abstract Doc Link 1459654 Disease Relevance 0 Pain Relevance 0.48
The influence of a GABA transaminase inhibitor, gamma-vinyl GABA, on voluntary morphine consumption in the rat.
Regulation (influence) of transaminase associated with gaba and morphine
3) Confidence 0.35 Published 1981 Journal Psychopharmacology (Berl.) Section Title Doc Link 6798609 Disease Relevance 0.17 Pain Relevance 1.00
It completely antagonized the toxic effects of paracetamol on certain enzymes (GOT, GPT and alkaline phosphatase) in serum as well as in isolated hepatic cells.
Regulation (effects) of GOT associated with paracetamol
4) Confidence 0.26 Published 1993 Journal J Ethnopharmacol Section Abstract Doc Link 8133653 Disease Relevance 0.09 Pain Relevance 0.27
Change in serum Glutamate Oxaloacetate Transaminase (GOT), Glutamate Pyruvate Transaminase (GPT), alkaline phosphatase (ALP), albumin, total protein and bilirubin were also determined.
Spec (determined) Regulation (Change) of GOT associated with glutamate
5) Confidence 0.25 Published 2007 Journal Pak. J. Biol. Sci. Section Abstract Doc Link 19070082 Disease Relevance 0.31 Pain Relevance 0.27
There was a trend toward normalization of serum glutamic oxaloacetic transaminase (SGOT) values.
Regulation (values) of transaminase
6) Confidence 0.23 Published 1976 Journal Arch. Gen. Psychiatry Section Abstract Doc Link 1259527 Disease Relevance 0.09 Pain Relevance 0.16
The clinical trial was studied concentrating on the observation of side effects and laboratory findings, especially the change of transaminase after anesthesia with GOF (gas-oxygen-fluothane).
Regulation (change) of transaminase associated with anesthesia
7) Confidence 0.22 Published 1983 Journal Jpn J Antibiot Section Abstract Doc Link 6573518 Disease Relevance 0 Pain Relevance 0.10
Change in serum Glutamate Oxaloacetate Transaminase (GOT), Glutamate Pyruvate Transaminase (GPT), alkaline phosphatase (ALP), albumin, total protein and bilirubin were also determined.
Spec (determined) Regulation (Change) of Transaminase associated with glutamate
8) Confidence 0.22 Published 2007 Journal Pak. J. Biol. Sci. Section Abstract Doc Link 19070082 Disease Relevance 0.31 Pain Relevance 0.27
The patient was discharged from hospital in stable condition and with a slight alteration in the transaminase levels.
Regulation (alteration) of transaminase
9) Confidence 0.21 Published 1999 Journal Gastroenterol Hepatol Section Abstract Doc Link 10396106 Disease Relevance 0.70 Pain Relevance 0.47
The same dose of plant extract (500 mg/kg) was able to significantly prevent (P < 0.05) CCl4-induced rise in serum enzymes and the estimated values of ALP, GOT and GPT were 220 +/- 30, 207 +/- 95 and 75 +/- 38, respectively. 7.
Regulation (values) of GOT
10) Confidence 0.18 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7789738 Disease Relevance 0.20 Pain Relevance 0.32
In Vitro antioxidative activity of pumpkin seed (Cucurbita pepo) protein isolate and its In Vivo effect on alanine transaminase and aspartate transaminase in acetaminophen-induced liver injury in low protein fed rats.
Regulation (effect) of aspartate transaminase in liver associated with paracetamol and injury
11) Confidence 0.16 Published 2006 Journal Phytother Res Section Title Doc Link 16807884 Disease Relevance 0.30 Pain Relevance 0.31
Subsequently the effects of the isolate on the plasma activity levels of alanine transaminase and aspartate transaminase against acetaminophen induced acute liver injury in low-protein fed male Sprague-Dawley rats were ascertained.
Regulation (effects) of aspartate transaminase in liver associated with paracetamol and injury
12) Confidence 0.16 Published 2006 Journal Phytother Res Section Abstract Doc Link 16807884 Disease Relevance 0.25 Pain Relevance 0.26
The dynamic profile for aspAT (Fig. 5), known to be regulated by CS (Garlatti et al. 1996; Pave-Preux et al. 1988) resembled TAT, however, incorporation of a capacity-limited stimulation by DR(N) seemed to provide the best fit for the data.
Regulation (regulated) of aspAT associated with corticosteroid
13) Confidence 0.15 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.09
Their effect on the body and organs weight and certain biochemical profiles including total serum protein, cholesterol, triglycerides, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum testosterone, and FSH levels were also measured.
Regulation (effect) of serum glutamic oxaloacetic transaminase in body
14) Confidence 0.14 Published 2004 Journal Neuro Endocrinol. Lett. Section Abstract Doc Link 15349082 Disease Relevance 0 Pain Relevance 0.26
This protective effect was not observed in rats fed a low protein diet and manifested in the concentrations of GPT and GOT in plasma and GSH levels in liver.
Regulation (concentrations) of GOT in plasma
15) Confidence 0.14 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788177 Disease Relevance 0.17 Pain Relevance 0.26
ASL, one of the five urea-cycle enzymes known to be secondarily regulated by CS, showed similar profile as TAT or aspAT, however incorporation of the biosignal (Model C) was necessary for satisfactory fitting of the data.
Regulation (regulated) of aspAT associated with corticosteroid
16) Confidence 0.13 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.12
mg/kg dose of F2 alone) showed no change in CK-MB, LDH, GOT, ALK-P, and uric acid compared to Group I.
Neg (no) Regulation (change) of GOT
17) Confidence 0.13 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952329 Disease Relevance 0.23 Pain Relevance 0
Statistically, Metrifonate did not show any influence on transaminase SGOT, SGPT, and LDH during and after the course of treatment.
Regulation (influence) of transaminase SGOT
18) Confidence 0.06 Published 1976 Journal Immun. Infekt. Section Abstract Doc Link 1017847 Disease Relevance 0.65 Pain Relevance 0.09
All subjects with significant elevations of transaminase values in these studies took daily naltrexone dosages higher than recommended for opioid addiction.
Regulation (values) of transaminase associated with addiction and opioid
19) Confidence 0.06 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 3092099 Disease Relevance 0.10 Pain Relevance 0.28
The daily dosage of naltrexone recommended for opioid addiction did not cause abnormalities of serum transaminase values in these studies.
Regulation (values) of transaminase associated with addiction, congenital anomalies and opioid
20) Confidence 0.06 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 3092099 Disease Relevance 0.29 Pain Relevance 0.29

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