INT42104

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Context Info
Confidence 0.44
First Reported 1983
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 4
Total Number 8
Disease Relevance 5.67
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a)
protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)
Anatomy Link Frequency
hepatocyte 1
germline 1
duct 1
Cdkn2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 10 100.00 Very High Very High Very High
Chronic pancreatitis 2 98.42 Very High Very High Very High
potassium channel 4 96.70 Very High Very High Very High
Pain 1 78.88 Quite High
imagery 2 75.04 Quite High
member 8 1 73.68 Quite High
melanocortin 1 receptor 2 71.56 Quite High
anesthesia 2 63.28 Quite High
medulla 1 37.04 Quite Low
ischemia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Acute Renal Failure 15 100.00 Very High Very High Very High
Cancer 6 100.00 Very High Very High Very High
Pancreatic Cancer 9 99.58 Very High Very High Very High
Skin Cancer 16 99.28 Very High Very High Very High
Pancreatitis 2 98.42 Very High Very High Very High
Adenocarcinoma 1 98.40 Very High Very High Very High
Colon Cancer 1 97.68 Very High Very High Very High
Injury 3 97.48 Very High Very High Very High
Diabetes Mellitus 83 96.10 Very High Very High Very High
Death 2 95.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the effect of clonidine, administered orally, on the prolonged course of HgCl2-induced ARF, two groups of rats were studied for a period of 5 days after injury.
Spec (determine) Regulation (effect) of ARF associated with injury and clonidine
1) Confidence 0.44 Published 1983 Journal J. Lab. Clin. Med. Section Abstract Doc Link 6226755 Disease Relevance 0.33 Pain Relevance 0.42
In this study, the authors aimed to investigate the effect of melatonin on arginase activity, ornithine, and NO levels on the myoglobinuric ARF formed by intramuscular (i.m.) injection of hypertonic glycerol.
Spec (investigate) Regulation (effect) of ARF associated with acute renal failure
2) Confidence 0.44 Published 2006 Journal Ren Fail Section Abstract Doc Link 16825094 Disease Relevance 0.85 Pain Relevance 0.06
In this study, we aimed to investigate the effect of melatonin, a potent free radical scavenger, on the myoglobinuric ARF formed by injecting hypertonic glycerol intramuscularly (i.m.).
Spec (investigate) Regulation (effect) of ARF associated with acute renal failure
3) Confidence 0.26 Published 2004 Journal Ren Fail Section Abstract Doc Link 15526905 Disease Relevance 0.37 Pain Relevance 0.06
This study evaluates whether duct lesions in chronic pancreatitis tissues of patients without pancreatic cancer also harbor genetic alterations in the p16(INK4a) tumor-suppressor gene, and thus represent high-risk precursors for pancreatic cancer.
Spec (whether) Regulation (alterations) of p16 in duct associated with cancer, pancreatic cancer and chronic pancreatitis
4) Confidence 0.20 Published 2001 Journal Surgery Section Abstract Doc Link 11283541 Disease Relevance 0.64 Pain Relevance 0.17
Pancreatic cancer is characterized by alterations in K-Ras, INK4a, Tp53 and SMAD4.
Regulation (alterations) of INK4a associated with pancreatic cancer
5) Confidence 0.11 Published 2006 Journal Praxis Section Abstract Doc Link 17111879 Disease Relevance 1.40 Pain Relevance 0.15
Our findings argue against an important predisposing effect of the MC1R and CDKN2A genes for ocular melanoma.
Regulation (effect) of CDKN2A associated with skin cancer
6) Confidence 0.08 Published 2003 Journal Melanoma Res. Section Abstract Doc Link 12883368 Disease Relevance 0.43 Pain Relevance 0.07
We explored the presence of germline alterations in CDK4 exon 2, CDKN2A and MC1R in a hospital-based study of 89 melanoma cases from 89 families with at least two members affected by cutaneous melanoma.
Regulation (alterations) of CDKN2A in germline associated with skin cancer
7) Confidence 0.06 Published 2010 Journal Melanoma Res. Section Abstract Doc Link 20539244 Disease Relevance 0.55 Pain Relevance 0
There are now at least 20 loci containing genes that increase the risk of T2D, including potassium channels (KCNJ11 [potassium inwardly-rectifying channel, subfamily J, member 11] and KCNQ1 [potassium voltage-gated channel, KQT-like subfamily, member 1]) [19], cell cycle regulators (CDKAL1 [regulatory subunit associated protein 1-like 1], CDKN2A-2B [cyclin-dependent kinase inhibitor 2A-2B], and CDC123-CAMK1D [cell division cycle 123 homolog- calcium/calmodulin-dependent protein kinase ID]) [20], nuclear hormone receptor (PPARG [peroxisome proliferator-activated receptor gamma]) [21], melatonin receptor (MTNR1B [melatonin receptor 1B]) [22], transcription factors (TCF7L2 [transcription factor 7-like 2], TCF2 or HNF1B [hepatocyte nuclear factor 1 beta], HHEX [hematopoietically expressed homeobox], and JAZF1 [JAZF zinc finger 1]) [23], translational regulator (IGF2BP2 [insulin-like growth factor 2 mRNA binding protein 2]) [24], zinc transporter (SLC30A8 [solute carrier family 30 zinc transporter member 8]) [25], apoptosis components (THADA [thyroid adenoma associated]) [26], metalloprotease (ADAMTS9 [ADAM metallopeptidase with thrombospondin type 1 motif, 9]) [27], calcium homeostasis component (WFS1 [Wolfram syndrome 1 homolog]) [28], fat mass and obesity-associated gene (FTO [fat mass and obesity associated]) [29], pancreas organogenesis (NOTCH2 [Notch homolog 2]) [30], and surface glycoprotein (TSPAN8 [tetraspanin-8]) [31].
Regulation (regulators) of CDKN2A-2B in hepatocyte associated with oxidative phosphorylation disease, thyroid neoplasm, diabetes mellitus, member 8, obesity, potassium channel and apoptosis
8) Confidence 0.05 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2901187 Disease Relevance 1.11 Pain Relevance 0.12

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