INT42116

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Context Info
Confidence 0.05
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.56
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ME1) mitochondrion (ME1) small molecule metabolic process (ME1)
oxidoreductase activity (ME1) carbohydrate metabolic process (ME1) cytoplasm (ME1)
Anatomy Link Frequency
plasma 1
liver 1
spike 1
ME1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 2 100.00 Very High Very High Very High
antagonist 1 99.60 Very High Very High Very High
cytokine 21 99.08 Very High Very High Very High
fluoxetine 2 98.28 Very High Very High Very High
cryotherapy 76 90.32 High High
agonist 3 80.08 Quite High
Serotonin 1 78.64 Quite High
ischemia 2 75.60 Quite High
noradrenaline 2 69.28 Quite High
Analgesic 2 59.56 Quite High
Disease Link Frequency Relevance Heat
Occupational Lung Diseases 2 93.44 High High
Lung Cancer 45 80.24 Quite High
Increased Venous Pressure Under Development 4 79.12 Quite High
Diabetes Complications 1 77.76 Quite High
Arrhythmia Under Development 2 76.56 Quite High
Cv Unclassified Under Development 2 75.60 Quite High
Injury 6 74.08 Quite High
Pressure And Volume Under Development 2 60.16 Quite High
Non-small-cell Lung Cancer 1 57.04 Quite High
Lichen 2 53.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Statistically significant increases in the activities of glutamate dehydrogenase, sorbitol dehydrogenase, malate dehydrogenase, ornithine transcarbamoylase, and arginase were observed in the plasma and liver.
Positive_regulation (increases) of malate dehydrogenase in plasma associated with glutamate
1) Confidence 0.05 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734249 Disease Relevance 0.44 Pain Relevance 0.43
When fluoxetine injection preceded administration of a weakly stimulatory dose of 5-HTP, a prolonged elevation in PRL level was observed. methysergide (MES), a 5-HT antagonist, administered in a 10 mg/kg dose produced no change in PRL level, while the 25 mg/kg dose initially produced a spike in PRL level which subsequently dropped slightly below the control level.
Positive_regulation (elevation) of MES in spike associated with antagonist and fluoxetine
2) Confidence 0.02 Published 1983 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 6230284 Disease Relevance 0 Pain Relevance 0.32
Statistically significant increases in the activities of glutamate dehydrogenase, sorbitol dehydrogenase, malate dehydrogenase, ornithine transcarbamoylase, and arginase were observed in the plasma and liver.
Positive_regulation (increases) of malate dehydrogenase in liver associated with glutamate
3) Confidence 0.02 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734249 Disease Relevance 0.44 Pain Relevance 0.43
Small amounts of ROS are produced from endothelial NADP (H) oxidase activated by growth factors and cytokines.
Positive_regulation (activated) of NADP associated with cytokine
4) Confidence 0.01 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.42 Pain Relevance 0.15
In this context the increase of p-AKT was reversed by gefitinib in Ist-Mes-1 and MPP89, whereas no change of p-AKT in Ist-Mes-2 was observed, because levels of activated AKT were non-detectable.
Positive_regulation (activated) of Ist-Mes-2
5) Confidence 0.01 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.26 Pain Relevance 0

General Comments

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