INT42121

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Context Info
Confidence 0.42
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.92
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLEK) extracellular region (PLEK) cytoplasm (PLEK)
Anatomy Link Frequency
platelet 8
PLEK (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 14 99.00 Very High Very High Very High
antagonist 3 79.92 Quite High
Angina 2 69.76 Quite High
Analgesic 1 25.00 Low Low
anesthesia 1 25.00 Low Low
cva 4 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombosis 6 99.90 Very High Very High Very High
Acute Coronary Syndrome 53 99.04 Very High Very High Very High
Hemorrhage 2 97.76 Very High Very High Very High
Cerebrovascular Disease 2 93.92 High High
Cardiovascular Disease 2 92.32 High High
Neutropenia 1 88.00 High High
Disease 6 87.60 High High
Coronary Artery Disease 17 85.20 High High
Increased Venous Pressure Under Development 1 75.00 Quite High
Cv General 3 Under Development 6 69.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results obtained before and 3 and 24 h after the drug administration induced us to think that platelet-specific substances released during the ischemic exercise can affect the hemorheological parameters and that ASA may be able to interfere with these reactions by inhibiting the platelet release.
Negative_regulation (inhibiting) of Localization (release) of platelet in platelet associated with aspirin
1) Confidence 0.42 Published 1983 Journal Ric Clin Lab Section Abstract Doc Link 6231713 Disease Relevance 0.16 Pain Relevance 0.13
Trapidil is an anti-platelet substance which acts on platelets through various mechanisms including inhibition of the release of "platelet derived growth factor".
Negative_regulation (inhibition) of Localization (release) of platelet in platelet
2) Confidence 0.42 Published 1996 Journal Herz Section Abstract Doc Link 8647575 Disease Relevance 0.80 Pain Relevance 0.37
At the same dosages, occluded thrombus formation and platelet release reactions were also markedly suppressed.
Negative_regulation (suppressed) of Localization (release) of platelet in platelet associated with thrombosis
3) Confidence 0.42 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10079002 Disease Relevance 0.28 Pain Relevance 0.12
Interestingly, the levels of platelet-secreted glycoprotein SPARC were decreased in platelets from NSTE-ACS patients as compared to stable controls, which is consistent with a platelet secretion associated to platelet activation in NSTE-ACS.
Negative_regulation (decreased) of Localization (secreted) of platelet in platelets associated with acute coronary syndrome
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.68 Pain Relevance 0

General Comments

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