INT42132

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Context Info
Confidence 0.51
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.12
Pain Relevance 6.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TCEA1) nucleolus (TCEA1) nucleus (TCEA1)
DNA binding (TCEA1)
Anatomy Link Frequency
posterior 4
SII 2
Plasma 1
TCEA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatosensory cortex 185 100.00 Very High Very High Very High
lidocaine 6 99.98 Very High Very High Very High
Acupuncture 125 99.50 Very High Very High Very High
Trigeminal neuralgia 9 98.84 Very High Very High Very High
rheumatoid arthritis 2 98.52 Very High Very High Very High
imagery 32 98.06 Very High Very High Very High
Glutamate 4 97.60 Very High Very High Very High
backache 2 96.88 Very High Very High Very High
primary somatosensory cortex 146 96.32 Very High Very High Very High
Pain 45 93.68 High High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 285 99.44 Very High Very High Very High
Headache 9 98.84 Very High Very High Very High
Rheumatoid Arthritis 6 98.52 Very High Very High Very High
Low Back Pain 3 96.88 Very High Very High Very High
Sacroiliitis 6 91.96 High High
Adhesions 39 82.72 Quite High
Congenital Anomalies 9 80.88 Quite High
Nociception 2 75.80 Quite High
INFLAMMATION 48 75.00 Quite High
Pain 35 74.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the case of Subject 1, the decrease in activity in anterior SII is not as pronounced as that seen in Subject 2 (also note difference in Figure 2), although the concurrent increase in posterior SII activity (compare module P with P') with decreased anterior SII activity (compare module A with A') is consistent with the shift in activation along the posterior-anterior axis observed in Subject 2.
Negative_regulation (decreased) of SII in posterior
1) Confidence 0.51 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC552304 Disease Relevance 0 Pain Relevance 0
This second component was almost completely eliminated during lidocaine blockade of SII.
Negative_regulation (blockade) of SII in SII associated with somatosensory cortex and lidocaine
2) Confidence 0.48 Published 1998 Journal Neuroreport Section Abstract Doc Link 9855284 Disease Relevance 0 Pain Relevance 0.86
In anesthetized animals, glutamate stimulation of SII decreased SEP latency and increased SEP amplitude, whereas no changes were evident during lidocaine blockade of SII.
Negative_regulation (blockade) of SII in SII associated with somatosensory cortex, glutamate and lidocaine
3) Confidence 0.48 Published 1998 Journal Neuroreport Section Abstract Doc Link 9855284 Disease Relevance 0 Pain Relevance 0.87
These findings suggest a general reduction of SI and SII processing in patients with TN, indicating a long-term modulation of somatosensory function and pointing to an attempt of cortical adaptation to potentially painful stimuli.
Negative_regulation (reduction) of SII associated with pain and trigeminal neuralgia
4) Confidence 0.44 Published 2009 Journal Hum Brain Mapp Section Abstract Doc Link 19365802 Disease Relevance 0.84 Pain Relevance 0.96
Neuroelectric source imaging revealed significantly elevated activity in SI and posterior parietal cortex, and significantly decreased activity in ipsilateral SII cortex when referred sensations were present.
Negative_regulation (decreased) of SII in posterior associated with imagery
5) Confidence 0.41 Published 2000 Journal Neuroreport Section Abstract Doc Link 10841347 Disease Relevance 0 Pain Relevance 0.51
In the case of Subject 1, the decrease in activity in anterior SII is not as pronounced as that seen in Subject 2 (also note difference in Figure 2), although the concurrent increase in posterior SII activity (compare module P with P') with decreased anterior SII activity (compare module A with A') is consistent with the shift in activation along the posterior-anterior axis observed in Subject 2.
Negative_regulation (decrease) of SII in posterior
6) Confidence 0.37 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC552304 Disease Relevance 0 Pain Relevance 0
The same conditions that led to the decrease in activity in SI and anterior SII also led to an increase in activity in posterior SII [4].
Negative_regulation (decrease) of SII in posterior
7) Confidence 0.37 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1087848 Disease Relevance 0 Pain Relevance 0.10
In the controls, we found that the SII decreases with increasing age (P less than 0.001) and is higher in males than in females (P less than 0.005).
Negative_regulation (decreases) of SII
8) Confidence 0.36 Published 1983 Journal Clin. Rheumatol. Section Abstract Doc Link 6235086 Disease Relevance 1.02 Pain Relevance 0.36
This would explain the marked reduction in SII ERD and ERS in the ADHD group.
Negative_regulation (reduction) of SII ERD associated with somatosensory cortex and attention deficit hyperactivity disorder
9) Confidence 0.24 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2266931 Disease Relevance 0.38 Pain Relevance 0.70
Additionally, the ADHD group showed a substantial decrease in SII alpha and beta power during ERD (decreases in power of cortical oscillations below baseline) and ERS (increases in power of cortical oscillations above baseline).
Negative_regulation (decrease) of SII associated with somatosensory cortex and attention deficit hyperactivity disorder
10) Confidence 0.24 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2266931 Disease Relevance 0.61 Pain Relevance 0.53
As observed in our findings, acupuncture at ST36 and nonacupoint shared a similar activation pattern in the somatosensory areas (SI and SII) during the needling manipulation period.
Negative_regulation (shared) of SII associated with acupuncture
11) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989943 Disease Relevance 0.13 Pain Relevance 0.54
Irrespective of whether stimuli were randomly or predictably presented, the ADHD group showed substantive power decreases in SII alpha and beta ERD and SII beta rebound ERS relative to controls as well as a significantly shorter SII beta rebound.
Negative_regulation (decreases) of SII associated with somatosensory cortex and attention deficit hyperactivity disorder
12) Confidence 0.08 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2266931 Disease Relevance 0.61 Pain Relevance 0.75
Plasma sTF and D-D levels were also significantly lower in HSD patients, whereas sTM levels remained at control levels.


Negative_regulation (lower) of sTF in Plasma
13) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2819256 Disease Relevance 0.53 Pain Relevance 0.10

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