INT42133

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 5.61
Pain Relevance 5.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TCEA1) nucleolus (TCEA1) nucleus (TCEA1)
DNA binding (TCEA1)
Anatomy Link Frequency
skin 3
MCtx 2
plasma 1
parietal 1
TCEA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatosensory cortex 229 100.00 Very High Very High Very High
primary somatosensory cortex 240 99.44 Very High Very High Very High
Anterior cingulate cortex 10 99.10 Very High Very High Very High
insula 19 99.00 Very High Very High Very High
rheumatoid arthritis 2 98.84 Very High Very High Very High
backache 2 98.32 Very High Very High Very High
Acupuncture 125 97.92 Very High Very High Very High
Inflammation 33 97.76 Very High Very High Very High
Analgesic 4 97.12 Very High Very High Very High
Pain 155 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 380 99.36 Very High Very High Very High
Rheumatoid Arthritis 6 98.84 Very High Very High Very High
Low Back Pain 5 98.32 Very High Very High Very High
INFLAMMATION 48 97.76 Very High Very High Very High
Brain Injury 72 97.56 Very High Very High Very High
Fibromyalgia 80 96.06 Very High Very High Very High
Cv General 3 Under Development 3 94.96 High High
Cognitive Disorder 22 93.76 High High
Pain 145 93.36 High High
Sacroiliitis 6 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although an influence mediated via direct callosal projections from ipsilateral SI to contralateral SI [2] should not be ruled out, the data presented in this study lead us to propose that SII is the major source of the modulated SI response to contralateral skin stimulation that is observed under a variety of stimulus conditions [16-19].
Gene_expression (source) of SII in skin associated with primary somatosensory cortex
1) Confidence 0.60 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1087848 Disease Relevance 0 Pain Relevance 0.41
Simoes et al. [9] showed significant suppression of the MEG SII response in humans, with simultaneous inputs delivered to the same skin sites, and Hoechstetter et al. [10] described "interactions" in SII cortex (a response that was not the summation of the ipsilateral and contralateral response) to simultaneous bilateral stimuli.
Gene_expression (response) of MEG SII in skin
2) Confidence 0.58 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC552304 Disease Relevance 0 Pain Relevance 0.03
For example, Carreras and Andersson [3] found that for a sizable fraction of the cat SII neurons in their study, ipsilateral mechanical skin stimulation inhibited the response to contralateral stimulation, whereas in contrast, Picard et al. [4] found in their study of neurons in the distal forelimb regions of cat SII that simultaneous delivery of contralateral and ipsilateral mechanical skin stimuli led to strong facilitation of SII neuron response.
Gene_expression (neurons) of SII in skin
3) Confidence 0.58 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC552304 Disease Relevance 0.06 Pain Relevance 0
The map in Figure 7 is indicative of the type result obtained by performing a "cross-modal" correlation (correlation of responses evoked by 2 different modes of stimulation) in all the subjects in which SI and SII was simultaneously imaged.
Gene_expression (imaged) of SII
4) Confidence 0.58 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1087848 Disease Relevance 0 Pain Relevance 0
Comparisons between SI and SII responses
Gene_expression (responses) of SII
5) Confidence 0.58 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1087848 Disease Relevance 0 Pain Relevance 0
In the hemisphere ipsilateral to the stimulation, only one source was estimated in SII, and its peak latency was significantly (approximately 18 ms on average) longer than that of the SII source in the contralateral hemisphere.
Gene_expression (source) of SII
6) Confidence 0.53 Published 2002 Journal Neuroscience Section Abstract Doc Link 12127094 Disease Relevance 0.20 Pain Relevance 0.90
A borderline SII was found in 1 of the 5 patients with rheumatoid arthritis.
Gene_expression (found) of SII associated with rheumatoid arthritis
7) Confidence 0.50 Published 1983 Journal Clin. Rheumatol. Section Abstract Doc Link 6235086 Disease Relevance 1.18 Pain Relevance 0.38
The present work was undertaken to study whether MCtx participated in SII producing descending modulation of ILN.
Gene_expression (producing) of SII in MCtx
8) Confidence 0.39 Published 1994 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 7750169 Disease Relevance 0.23 Pain Relevance 0
MCtx was involved in SII producing descending modulation of ILN.
Gene_expression (producing) of SII in MCtx
9) Confidence 0.39 Published 1994 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 7750169 Disease Relevance 0.24 Pain Relevance 0
Some evidence also indicates that the averaged fMRI activation level of the SII, rather than the SI, is positively correlated with acupuncture-induced analgesic effect across the subjects [10].
Gene_expression (level) of SII associated with analgesic and acupuncture
10) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989943 Disease Relevance 0.28 Pain Relevance 0.63
Irrespective of whether stimuli were randomly or predictably presented, the ADHD group showed substantive power decreases in SII alpha and beta ERD and SII beta rebound ERS relative to controls as well as a significantly shorter SII beta rebound.
Gene_expression (beta rebound) of SII associated with somatosensory cortex and attention deficit hyperactivity disorder
11) Confidence 0.28 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2266931 Disease Relevance 0.58 Pain Relevance 0.73
Irrespective of whether stimuli were randomly or predictably presented, the ADHD group showed substantive power decreases in SII alpha and beta ERD and SII beta rebound ERS relative to controls as well as a significantly shorter SII beta rebound.
Gene_expression (beta rebound) of SII associated with somatosensory cortex and attention deficit hyperactivity disorder
12) Confidence 0.28 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2266931 Disease Relevance 0.60 Pain Relevance 0.75
Group comparisons revealed that overall, SII responding of adults with ADHD showed markedly less source power than that of controls (Figure 5C).
Gene_expression (responding) of SII associated with somatosensory cortex and attention deficit hyperactivity disorder
13) Confidence 0.25 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2266931 Disease Relevance 0.39 Pain Relevance 0.37
In the control group, SII exhibited strong early ERS from 5 Hz to 25 Hz followed by ERD and beta rebound ERS, consistent with the control Random SII response.
Gene_expression (response) of SII associated with somatosensory cortex
14) Confidence 0.25 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2266931 Disease Relevance 0.30 Pain Relevance 0.66
METHODS: Thirty-four patients with stable angina were divided into two groups depending upon the presence or absence of an SII gap of at least 1 min between onset of ST depression and appearance of angina on ETT.
Gene_expression (presence) of SII
15) Confidence 0.22 Published 2001 Journal Clin Cardiol Section Body Doc Link 11195606 Disease Relevance 0.09 Pain Relevance 0
Applying a low stimulus pressure to both healthy controls and FM patients resulted in 13 regions showing statistically greater activation for patients (that is, contralateral SI, inferior parietal lobule, insula, ACC and posterior cingulate cortex; ipsilateral SII cortex; bilateral superior temporal gyrus, and cerebellum) whereas only one region (ipsilateral medial frontal gyrus) demonstrated greater activation in controls.
Gene_expression (cortex) of SII in parietal associated with insula, anterior cingulate cortex and fibrositis
16) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794529 Disease Relevance 0.62 Pain Relevance 0.65
Based on the measured plasma sTF, sTM and D-D levels, our results show that compared to control, NS-resuscitated TBI patients exhibit activation of coagulation with concurrent down-regulation of anticoagulant systems and fibrinolysis.
Gene_expression (levels) of sTF in plasma associated with brain injury
17) Confidence 0.00 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.85 Pain Relevance 0.04

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