INT42140

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Context Info
Confidence 0.19
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.45
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle 3
myocyte 1
hearts 1
Myo1f (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 4 100.00 Very High Very High Very High
Opioid 4 99.36 Very High Very High Very High
Paracetamol 180 98.32 Very High Very High Very High
ischemia 2 96.96 Very High Very High Very High
Kinase C 2 85.24 High High
Kappa opioid receptor 6 75.00 Quite High
antagonist 2 74.72 Quite High
lidocaine 5 61.60 Quite High
agonist 5 59.28 Quite High
addiction 6 53.92 Quite High
Disease Link Frequency Relevance Heat
Frailty 15 99.62 Very High Very High Very High
Apoptosis 30 99.38 Very High Very High Very High
Cv Unclassified Under Development 2 96.96 Very High Very High Very High
Aging 114 96.60 Very High Very High Very High
Body Weight 12 91.32 High High
Hyperglycemia 12 80.24 Quite High
Hepatotoxicity 3 59.08 Quite High
Muscle Disease 3 49.44 Quite Low
Obesity 6 29.92 Quite Low
Death 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes of myosin and its ATPase in "neuronally" and "mechanically" contralateral muscles after cross-reinnervation in normal and capsaicin-treated rats.
Gene_expression (Changes) of myosin in muscles associated with qutenza
1) Confidence 0.19 Published 1984 Journal Exp. Neurol. Section Title Doc Link 6236994 Disease Relevance 0 Pain Relevance 0.29
Our results show that aging skeletal muscle exhibits impaired Akt kinase activity and that acetaminophen-induced improvements in Akt signaling are associated with increases in myocyte size and the expression of myosin and actin, along with decreases in muscle apoptosis.
Gene_expression (expression) of myosin in muscle associated with paracetamol, aging and apoptosis
2) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 1.02 Pain Relevance 0.46
In summary, age-associated decreases in muscle Akt kinase function may be related to increased muscle apoptosis and atrophy, and decreases in myosin and actin expression (Figure 9).
Gene_expression (expression) of myosin in muscle associated with frailty and apoptosis
3) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.86 Pain Relevance 0.42
Impairments in Akt function occurred parallel to increases in myocyte apoptosis and decreases in myocyte size and the expression of myosin and actin.
Gene_expression (expression) of myosin in myocyte associated with apoptosis
4) Confidence 0.12 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2712760 Disease Relevance 0.38 Pain Relevance 0.23
Therefore, in Langendorff perfused rat hearts (n=30), the phosphorylation levels of cardiac myosin binding protein-C (cMyBP-C), troponin I and T (cTnI, cTnT) and myosin light chain 1 and 2 (MLC-1, MLC-2) were determined by 1- and 2-dimensional gel electrophoresis.
Spec (determined) Gene_expression (levels) of myosin in hearts
5) Confidence 0.03 Published 2007 Journal Basic Res Cardiol Section Abstract Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0.06
These findings are consistent with the hypothesis that kappa-opioid and alpha-adrenergic receptors decrease actin-myosin cycling rate, leading to a conservation of ATP and cardioprotection during ischemia.
Gene_expression (decrease) of actin-myosin associated with ischemia and opioid
6) Confidence 0.03 Published 2000 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11009483 Disease Relevance 0.10 Pain Relevance 0.39
These findings are consistent with the hypothesis that kappa-opioid and alpha-adrenergic receptors decrease actin-myosin cycling rate, leading to a conservation of ATP and cardioprotection during ischemia.
Gene_expression (decrease) of actin-myosin associated with ischemia and opioid
7) Confidence 0.03 Published 2000 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11009483 Disease Relevance 0.10 Pain Relevance 0.39
Using antibodies against b-actin and NMM IIA heavy chain, both myosin and actin were detected in the re-isolated peroxisomes.
Gene_expression (detected) of myosin
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0 Pain Relevance 0.03

General Comments

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